公开(公告)号：EP2421819B1

公开(公告)日：2014-03-05

申请号：EP10718104.2

申请日：2010-04-08

申请人： Bracco Imaging S.p.A

发明人： CITTERIO, Attilio ,  LATTUADA, Luciano ,  FERRIGATO, Aurelia ,  FRETTA, Roberta ,  MAZZON, Roberta ,  MELI, Gabriele ,  LEONARDI, Gabriella ,  UGGERI, Fulvio ,  VIGNALE, Evelin ,  VISIGALLI, Massimo

IPC分类号： C07C227/16

CPC分类号： C07C227/16 ,  C07C229/62

公开(公告)号：EP2580187B1

公开(公告)日：2015-05-27

申请号：EP11725069.6

申请日：2011-06-09

申请人： Bracco Imaging S.p.A

发明人： CITTERIO, Attilio ,  BATTISTINI, Elisa ,  BELNOME, Davide ,  BUONSANTI, Federica ,  LATTUADA, Luciano ,  LEONARDI, Gabriella ,  UGGERI, Fulvio ,  VIGNALE, Evelin ,  VISIGALLI, Massimo

IPC分类号： C07C231/10 ,  C07C237/46

CPC分类号： C07B39/00 ,  C07C231/10 ,  C07C231/12 ,  C07C231/14 ,  C07C235/48 ,  C07C237/46

公开(公告)号：EP2580187A1

公开(公告)日：2013-04-17

申请号：EP11725069.6

申请日：2011-06-09

申请人： Bracco Imaging S.p.A

发明人： CITTERIO, Attilio ,  BATTISTINI, Elisa ,  BELNOME, Davide ,  BUONSANTI, Federica ,  LATTUADA, Luciano ,  LEONARDI, Gabriella ,  UGGERI, Fulvio ,  VIGNALE, Evelin ,  VISIGALLI, Massimo

IPC分类号： C07C231/10 ,  C07C237/46

CPC分类号： C07B39/00 ,  C07C231/10 ,  C07C231/12 ,  C07C231/14 ,  C07C235/48 ,  C07C237/46

摘要： The present invention relates to a process for the preparation of iodinated phenols; in particular; it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted phenol compounds to the corresponding 3,5-disubstituted-2,4,6-triiodophenols, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.

公开(公告)号：EP2421819A1

公开(公告)日：2012-02-29

申请号：EP10718104.2

申请日：2010-04-08

申请人： Bracco Imaging S.p.A

发明人： CITTERIO, Attilio ,  LATTUADA, Luciano ,  FERRIGATO, Aurelia ,  FRETTA, Roberta ,  MAZZON, Roberta ,  MELI, Gabriele ,  LEONARDI, Gabriella ,  UGGERI, Fulvio ,  VIGNALE, Evelin ,  VISIGALLI, Massimo

IPC分类号： C07C227/16

CPC分类号： C07C227/16 ,  C07C229/62

摘要： The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5- disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.

公开(公告)号：EP2243767A1

公开(公告)日：2010-10-27

申请号：EP09158319.5

申请日：2009-04-21

申请人： Bracco Imaging S.p.A ,  Politecnico di Milano

发明人： CITTERIO, Attilio ,  LATTUADA, Luciano ,  LEONARDI, Gabriella ,  UGGERI, Fulvio ,  VIGNALE, Evelin ,  VISIGALLI, Massimo

IPC分类号： C07C227/16

CPC分类号： C07C227/16 ,  C07C229/62

摘要： The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.

摘要翻译： 本发明涉及一种制备碘化苯胺的方法; 特别涉及包括将3,5-二取代的苯胺直接碘化为相应的3,5-二取代-2,4,6-三碘苯胺的方法，它们是合成X射线造影剂的有用中间体， 以及造影剂本身的制备。