公开(公告)号：EP3392289A1

公开(公告)日：2018-10-24

申请号：EP16877744.9

申请日：2016-12-21

申请人： Bright Gene Bio-Medical Technology Co., Ltd.

发明人： YUAN, Jiandong ,  MENG, Fenghua ,  ZOU, Yan ,  FANG, Yuan ,  ZHONG, Zhiyuan

IPC分类号： C08G64/18 ,  C08G64/30 ,  A61K49/18

CPC分类号： A61K49/18 ,  A61K47/50 ,  C08G64/025 ,  C08G64/081 ,  C08G64/18 ,  C08G64/183 ,  C08G64/30

摘要： Disclosed in the present disclosure is a biodegradable amphiphilic polymer containing disulfide in the side chain, a self-crosslinked polymeric vesicle thereof and an application in the targeted therapy of lung cancer. The polymer is obtained by an activity-controllable ring-opening polymerization based on a cyclic carbonate monomer containing a functional group of dithiolane ring, which has a controllable molecular weight and a narrow molecular weight distribution, and does not require processes of protection and deprotection; the polymer obtained by the ring-opening polymerization of the cyclic carbonate monomer of the present disclosure has biodegradability and can be used to control the drug release system, the prepared lung cancer-targeted reduction-sensitive reversibly-crosslinked polymeric vesicle as a nanomedicine carrier supports stable long circulation in vivo. However, it is highly enriched in lung cancer tissues, enter cells efficiently, and rapidly decrosslinks in the cells to release drugs, so as to kill cancer cells with high potency and specificity and inhibit the growth of tumor effectively without causing toxic and side effects.

公开(公告)号：EP3150651A1

公开(公告)日：2017-04-05

申请号：EP15799082.1

申请日：2015-05-27

申请人： Bright Gene Bio-Medical Technology Co., Ltd.

发明人： MENG, Fenghua ,  ZOU, Yan ,  ZHONG, Zhiyuan

IPC分类号： C08G64/18 ,  C08G64/30 ,  C08G63/64 ,  A61K47/34

CPC分类号： C08G64/30 ,  A61K47/34 ,  C08G63/64 ,  C08G64/025 ,  C08G64/18 ,  C08G64/183

摘要： The invention relates to a carbonate polymer containing a functional group of disulfide five-membered ring in the side chain and application thereof. Said polymer can be prepared from the cyclic carbonate monomer containing a disulfide five-membered ring functional group through the activity controllable ring-opening polymerization. For the polymer, the molecular weight is controlled, the molecular weight distribution is narrowed and does not require the protection and deprotection procedures. The polymer prepared from the said carbonate monomer through the ring-opening polymerization has biodegradability, can be used for controlling drugs release system, and can be used to prepare tumor-targeted nano-drug carrier which is sensitive to reduction and is reversible cross-linking, can support long circulation in the body, in high concentration of cancers cells can rapidly release cross-linking in the cancer cells, to release drugs, to kill cancer cells with high efficiency and specificity. The biodegradable polymer has a good application value in the tissue engineering and bio-chip coating.

摘要翻译： 本发明涉及在侧链中含有二硫化五元环官能团的碳酸酯聚合物及其应用。 所述聚合物可以通过活性可控开环聚合由含有二硫化五元环官能团的环状碳酸酯单体制备。 对于聚合物，分子量受到控制，分子量分布变窄，不需要保护和脱保护程序。 由所述碳酸酯单体通过开环聚合制备的聚合物具有生物降解性，可用于控制药物释放体系，并且可用于制备对还原敏感的肿瘤靶向纳米药物载体，并且是可逆的交联 可以支持身体长期循环，在高浓度的癌细胞中可以快速释放癌细胞中的交联，释放药物，以高效率和特异性杀死癌细胞。 生物降解聚合物在组织工程和生物芯片涂层中具有良好的应用价值。

公开(公告)号：EP3421519A1

公开(公告)日：2019-01-02

申请号：EP17759282.1

申请日：2017-03-03

申请人： Bright Gene Bio-Medical Technology Co., Ltd.

发明人： MENG,Fenghua ,  ZOU, Yan ,  ZHONG, Zhiyuan ,  YUAN, Jiandong

IPC分类号： C08G64/18 ,  C08G64/30 ,  A61K9/51 ,  A61K47/34 ,  A61K47/42 ,  A61P35/00

摘要： Provided are an ovarian cancer specifically targeted biodegradable amphiphilic polymer, a polymer vesicle prepared thereby and use thereof. The biodegradable amphiphilic polymer is prepared by a polymer containing dithiocarbonate monomer bonded with targeting molecules. The polymer vesicle prepared with the biodegradable amphiphilic polymer can crosslink spontaneously without adding an extra crosslinker, and the crosslink has a reduction activity and hence can be used in drug controlled-release systems, and contributes to the clinical use and production of nano-drugs.

公开(公告)号：EP3150611A1

公开(公告)日：2017-04-05

申请号：EP15798938.5

申请日：2015-05-27

申请人： Bright Gene Bio-Medical Technology Co., Ltd.

发明人： MENG, Fenghua ,  ZOU, Yan ,  ZHONG, Zhiyuan

IPC分类号： C07D495/10 ,  A61K47/34 ,  C08G65/48 ,  C08G64/30 ,  C08G63/64 ,  C08J3/24

CPC分类号： C07D495/10 ,  A61K9/5153 ,  A61K47/34 ,  C08G63/64 ,  C08G64/025 ,  C08G64/183 ,  C08G64/30 ,  C08G64/305 ,  C08G64/42 ,  C08G65/48 ,  C08J3/24

摘要： Disclosed are a cyclic carbonate monomer containing a double-sulfur five-membered ring functional group, and preparation method thereof. The cyclic carbonate monomer can be simply and efficiently synthesized without protection and deprotection processes. The cyclic carbonate monomer of the present invention can be utilized to obtain polycarbonate having a controllable molecular weight and molecular weight distribution via ring opening polymerization, and has biodegradability and reduction-sensitive reversible crosslinking properties. The present invention can be used in a carrier having controllably released drug, a biological tissue scaffold or a biochip.

摘要翻译： 公开了含有双硫五元环官能团的环状碳酸酯单体及其制备方法。 环状碳酸酯单体可以简单有效地合成而没有保护和去保护过程。 本发明的环状碳酸酯单体可用于通过开环聚合获得具有可控分子量和分子量分布的聚碳酸酯，并且具有生物降解性和还原敏感性的可逆交联性。 本发明可用于具有可控制释放的药物，生物组织支架或生物芯片的载体中。