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177 条记录 (耗时 0.028 秒)

    SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS
    2.
    发明公开
    SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS 审中-公开
    自组装在酸性肿瘤微环境中的分子

    公开(公告)号：EP3177326A1

    公开(公告)日：2017-06-14

    申请号：EP15830109.3

    申请日：2015-08-07

    申请人： The Ohio State Innovation Foundation

    发明人： GOLDBERGER, Joshua E. ,  TWEEDLE, Michael F.

    IPC分类号： A61K47/50 ,  A61K49/22 ,  A61K51/12

    CPC分类号： A61K49/0069 ,  A61K49/0019 ,  A61K49/0056 ,  A61K49/14 ,  A61K49/18

    摘要： Disclosed are compositions that contain a plurality of biocompatible self-assembling molecules that transform from isolated molecules or spherical micelles while in blood serum into cylindrical nanofibers in the acidic extracellular environment of tumors, which can be used to achieve a higher relative concentration of imaging drug delivery, or radiotherapeutic agents at the tumor site compared to non-tumor tissues. This transition is rapid and reversible, indicating the system is in thermodynamic equilibrium.

    摘要翻译： 公开了含有多种生物相容性自组装分子的组合物，所述自组装分子从血清中的分离的分子或球形胶束转变成肿瘤的酸性细胞外环境中的圆柱形纳米纤维，其可用于实现更高的相对成像浓度 与非肿瘤组织相比，在肿瘤部位递送或放射治疗剂。 这种转变是快速且可逆的，表明系统处于热力学平衡状态。

    Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide
    4.
    发明公开
    Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide 审中-公开
    一种用于制备具有大环配位体的材料和用于容纳该配体与镧系制备药物制剂的方法

    公开(公告)号：EP2786768A1

    公开(公告)日：2014-10-08

    申请号：EP13162339.9

    申请日：2013-04-04

    申请人： Agfa Healthcare

    发明人： Buffel, Diederik ,  Leblans, Paul ,  Venneman, Jan

    IPC分类号： A61K49/18 ,  A61K49/10

    CPC分类号： A61K49/108 ,  A61K49/18

    摘要： The present invention relates to a process for preparing a macrocyclic ligand and for producing a pharmaceutical liquid formulation comprising a complex of said ligand with a lanthanide or similar compounds.
    The macrocyclic ligand of the present invention is a derivative of tetraaza macrocycles such as 1,4,7,10-tetraazacyclododecane (cyclen), 1,4,7,10-tetrazacyclotridecan (homocyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam), such as DOTA, TRITA, TETA, DOTMA, TCE-DOTA, DOTA-pNB, D03A, HP-D03A, D03A-butrol, D03MA, ODOTRA, D03A-L2, DOTP, DOTMP, DO2a, THP, THED, DOTAM, DOTTA. The preferred lanthanide and similar compounds are Gadolinium (Gd), Yttrium (Y) and Terbium (Tb).
    The process of the present invention aims to obtain an accurate balance between the ligand and the lanthanide, and to avoid the presence of free lanthanide in said formulation, by calculating the necessary amount of ligand for a formulation batch, measuring the moisture content of a sample of the material in said batch, calculating the total amount of moisture present of the batch and calculating the total amount of material which is required to prepare the batch size.
    In this way, the production of a pharmaceutical liquid formulation comprising a complex of a macrocyclic ligand with lanthanide is more accurate, faster and easier. The present invention is thus useful for the production of pharmaceutical liquid formulations comprising a complex of a macrocyclic ligand with a lanthanide, which can be used as contrast agents for magnetic resonance imaging.

    摘要翻译： 本发明涉及一种用于制备大环配位体和用于制备药物的液体制剂包含所述配体与镧系或类似的化合物的复合物的方法。 本发明的大环配体是四氮杂大环化合物的衍生物：如1,4,7,10- tetraazacyclododecanes（环烯），1,4,7,10- tetrazacyclotridecan（同源环烯）和1,4,8,11-四氮杂 （cyclam）：如DOTA，TRITA，TETA，DOTMA，TCE-DOTA，DOTA-硝基苄，D03A，HP-D03A，D03A-布醇，D03MA，ODOTRA，D03A-L2，DOTP，DOTMP，DO2A，THP，thed， DOTAM，DOTTA。 在优选的镧系和类似的化合物是钆（Gd），钇（Y）和铽（Tb）。 本发明的方法的目的是获得关于配体和镧系元素之间的精确平衡，并且避免在所述制剂，通过计算配体的必要量为制剂批次，测量样品的含水量游离镧系元素的存在 在所述批次的材料的，计算存在的批次的水分的总量，并计算所需要制备的批量大小材料的总量全部。 以这种方式，生产的药物液体制剂，其包含镧系元素与大环配体的复合物是更准确，更快速，更容易。 本发明是用于包括大环配体与镧系，其可以被用作用于磁共振成像造影剂的复合物制备药物液体配方和灰。因此是有用的。

    COMBINATION COMPRISING AN AGENT PROVIDING A SIGNAL, AN IMPLANT MATERIAL AND A DRUG
    8.
    发明公开
    COMBINATION COMPRISING AN AGENT PROVIDING A SIGNAL, AN IMPLANT MATERIAL AND A DRUG 审中-公开
    组合，其发射信号的植入材料与ARZEIMITTEL的装置

    公开(公告)号：EP1830902A2

    公开(公告)日：2007-09-12

    申请号：EP05819997.7

    申请日：2005-12-20

    申请人： CINVENTION AG

    发明人： ASGARI, Sohéil

    IPC分类号： A61L31/18 ,  A61L31/02

    CPC分类号： A61K49/18 ,  A61K47/6957 ,  A61K49/04 ,  A61L31/022 ,  A61L31/18

    摘要： The present invention relates to a combination for use in implantable medical devices, comprising at least one signal generating agent, which in a physical, chemical and/or biological measurement or verification method leads to detectable signals, at least one material for manufacture of an implantable medical device and/or at least one component of an implantable medical device, and at least one therapeutically active agent, which in an animal or human organism fulfills directly or indirectly a therapeutic function. The invention further relates to implantable medical devices comprising such a combination, and to methods for the determination of the extent of active agent release from implantable medical devices comprising such a combination.