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1.发明公开METHODS FOR THE PREPARATION OF PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权用于生产PYRROLOTRIAZINVERBINDUNGEN引致的，激酶抑制剂适合...
公开(公告)号：EP1562949A2
公开(公告)日：2005-08-17
申请号：EP03781756.6
申请日：2003-11-03
发明人： GODFREY, Jollie, Duaine, Jr. , HYNES, John, Jr. , DYCKMAN, Alaric, J. , LEFTHERIS, Katerina , SHI, Zhongping , WROBLESKI, Stephen, T. , DOUBLEDAY, Wendel, William , GROSSO, John, A.
IPC分类号： C07D487/04 , A61K31/53
CPC分类号： C07D487/04 , C07D207/50
摘要： Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.
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2.发明授权METHODS FOR THE PREPARATION OF PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权用于生产PYRROLOTRIAZINVERBINDUNGEN引致的，激酶抑制剂适合...
公开(公告)号：EP1562949B1
公开(公告)日：2009-12-30
申请号：EP03781756.6
申请日：2003-11-03
发明人： GODFREY, Jollie, Duaine, Jr. , HYNES, John, Jr. , DYCKMAN, Alaric, J. , LEFTHERIS, Katerina , SHI, Zhongping , WROBLESKI, Stephen, T. , DOUBLEDAY, Wendel, William , GROSSO, John, A.
IPC分类号： C07D487/04 , A61K31/53
CPC分类号： C07D487/04 , C07D207/50
摘要： Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.
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