-
1.发明授权PHOSPHONATE AND PHOSPHINATE COMPOUNDS AS GLUCOKINASE ACTIVATORS 有权膦酸盐和PHOSPHINATVERBINDUNGEN ALS葡萄糖激酶激活
公开(公告)号：EP2059522B1
公开(公告)日：2014-01-08
申请号：EP07812578.8
申请日：2007-07-03
发明人： RYONO, Dennis E. , CHENG, Peter T.W. , BOLTON, Scott A. , CHEN, Sean S. , SHI, Yan , MENG, Wei , TINO, Joseph A. , ZHANG, Hao , SULSKY, Richard B.
IPC分类号： C07F9/32 , C07F9/40 , A61K31/675 , A61P3/00
CPC分类号： C07F9/6539 , C07F9/582 , C07F9/587 , C07F9/65032 , C07F9/650964 , C07F9/650982 , C07F9/65181
-
2.发明公开PHOSPHONATE AND PHOSPHINATE COMPOUNDS AS GLUCOKINASE ACTIVATORS 有权膦酸盐和PHOSPHINATVERBINDUNGEN ALS葡萄糖激酶激活
公开(公告)号：EP2059522A2
公开(公告)日：2009-05-20
申请号：EP07812578.8
申请日：2007-07-03
发明人： RYONO, Dennis E. , CHENG, Peter T.W. , BOLTON, Scott A. , CHEN, Sean S. , SHI, Yan , MENG, Wei , TINO, Joseph A. , ZHANG, Hao , SULSKY, Richard B.
IPC分类号： C07F9/32 , C07F9/40 , A61K31/675 , A61P3/00
CPC分类号： C07F9/6539 , C07F9/582 , C07F9/587 , C07F9/65032 , C07F9/650964 , C07F9/650982 , C07F9/65181
摘要： Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure of Formula (I), wherein Formula (II) is a heteroaryl ring; R4 is -(CH2)n-Z-(CH2)m-PO(OR7)(OR8), -(CH2)nZ-(CH2)m-PO(OR7)R9, -(CH2)n-Z-(CH2)m-OPO(OR7)R9, -(CH2)nZ-(CH2)m-OPO(R9)(R10), or -(CH2)nZ-(CH2)m-PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
-
搜索结果
2 条记录 (耗时 0.015 秒)
