公开(公告)号：EP1358178A2

公开(公告)日：2003-11-05

申请号：EP02717381.4

申请日：2002-01-28

申请人： Bristol-Myers Squibb Company

发明人： O'CONNOR, Stephen, P. ,  LAWRENCE, R., Michael ,  SHI, Yan ,  STEIN, Philip, P.

IPC分类号： C07D401/06 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D401/14 ,  C07D211/56 ,  C07D409/12 ,  C07D471/08 ,  C07D405/12 ,  C07D491/08 ,  A61K31/4545 ,  A61P7/02

CPC分类号： C07D211/56 ,  C07D401/06 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/08

摘要： Sulfonamide lactams of the formula (I) wherein X, R?1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R7 and R8¿ are as described herein, are provided which inhibitors of Factor Xa and are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.