公开(公告)号：EP0667790A1

公开(公告)日：1995-08-23

申请号：EP93918635.0

申请日：1993-08-05

申请人： Bristol-Myers Squibb Company ,  McMASTER UNIVERSITY

发明人： SHOYAB, Mohammed ,  BROWN, Thomas Joseph ,  RICHARDS, Carl D. ,  GAULDIE, Jack

IPC分类号： A61K38 ,  C07K14

CPC分类号： C07K14/52 ,  A61K38/1841 ,  A61K38/204 ,  A61K38/2093 ,  A61K2300/00

摘要： A method for decreasing metalloproteinase activity in a patient that comprises the step of administering to said patient a therapeutic composition comprising the cytokine oncostatin-M, or a biologically active fragment, mutant, analog or fusion construct thereof. Also, a method for increasing TIMP activity in a patient that comprises the step of administering to said patient a therapeutic composition comprising the cytokine oncostatin-M, or a biologically active fragment, mutant, analog or fusion construct thereof. In addition a method for inhibiting or treating progression of a tumor in a patient that comprises the step of administering to said patient a therapeutic composition comprising oncostatin-M, or a biologically active fragment, mutant, analog, or fusion construct thereof, said method being effective to inhibit invasion by a tumor cell through an extracellular space, extracellular matrix, basement membrane, interstitial tissue or connective tissue. Also methods effective to treat inflammatory or degenerative disease, methods effective to stimulate erythropoiesis, and methods effective to regulate tissue remodeling and to promote healing of injury.