专利检索 ap:("Bristol-Myers Squibb Pharma Company") AND inv:"ALBRIGHT, Charles, F." 第 1 页

1.

发明公开
PEPTIDASE-CLEAVABLE, TARGETED ANTINEOPLASTIC DRUGS AND THEIR THERAPEUTIC USE 审中-公开
标题翻译：肽酶裂变，有针对性的抗肿瘤药物及其治疗用途

公开(公告)号：EP1263473A2

公开(公告)日：2002-12-11

申请号：EP01918798.8

申请日：2001-03-15

申请人： Bristol-Myers Squibb Pharma Company

发明人： COPELAND, Robert, A. , ALBRIGHT, Charles, F. , COMBS, Andrew, P. , DOWLING, Radine, L. , GRACIANI, Nilsa, R. , HAN, Wei , HIGLEY, C., Anne , HUANG, Pearl, S. , YUE, Eddy, W. , DIMEO, Susan, V.

IPC分类号： A61K47/48 , A61K31/704 , A61P35/00

CPC分类号： C07K7/06 , A61K38/00 , A61K47/65

摘要： This invention is directed to antineoplastic agents conjugated to enzyme-cleavable peptides comprising the amino acid recognition sequence of a membrane-bound and/or cell-secreted peptidase, and to the use of such conjugated compounds as chemotherapeutic agents in the targeted treatment of cancers.