专利检索 ap:("Bristol-Myers Squibb Pharma Company") AND inv:"YANG, Bingwei Vera" 第 1 页

1.

发明公开
SUBSTITUTED HETEROARYL AMIDE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NFkB ACTIVITY AND USE THEREOF 有权
标题翻译：取代HETEROARYLAMIDMODULATOREN糖皮质激素受体的活性，AP-1和/或这样的NFκB的使用与

公开(公告)号：EP1896434A1

公开(公告)日：2008-03-12

申请号：EP06718407.7

申请日：2006-01-13

申请人： Bristol-Myers Squibb Pharma Company

发明人： SHEPPECK, James E. , DHAR, T. G. Murali , DOWEYKO, Arthur M. P. , DOWEYKO, Lidia M. , GILMORE, John L. , WEINSTEIN, David S. , XIAO, Hai-Yun , YANG, Bingwei Vera

IPC分类号： C07D277/46

CPC分类号： C07D233/91 , C07D277/46 , C07D417/06

摘要： The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NFκB activity including obesity, diabetes, inflammatory- and immune-associated diseases, and have the structure (I) including all stereoisomers thereof, tautomers thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein X is selected from N, O, and S; Y is N or CR6; Z is a ring; and where R, Ra, Rb, Rc, Rd, R1, R2, R3, R4, and R5 are as defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.