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公开(公告)号：EP2760865B1
公开(公告)日：2018-07-11
申请号：EP12834688.9
申请日：2012-09-28
发明人： HO, Pil Su , YOON, Dong Oh , HAN, Sun Young , LEE, Won Il , KIM, Jung Sook , PARK, Woul Seong , AHN, Sung Oh , KIM, Hye Jung
IPC分类号： C07D471/14 , A61K31/4985 , A61P29/00 , A61P37/08 , A61P35/00
CPC分类号： C07D471/14 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention relates to novel heterocyclic compounds useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.
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公开(公告)号：EP3227271A2
公开(公告)日：2017-10-11
申请号：EP15865425.1
申请日：2015-11-30
发明人： PARK, Chan Hee , LEE, Sang Hwi , IM, Junhwan , LEE, Soon Ok , KIM, Jungsook , PARK, Heon Kyu , YUN, Jee Hun , KO, Kwang Seok , KIM, Hye Jung , KIM, Byungho , KIM, Mi Sun , KONG, Minjung , MOON, Hyung Jo
IPC分类号： C07D333/52 , C07D495/04 , A61K31/381 , A61P35/00
CPC分类号： C07D495/04 , C07D209/42 , C07D333/70 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D498/04
摘要： A heterocyclic derivative represented by formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, which has an inhibitory effect on the activation of STAT3 protein, and is useful for the prevention or treatment of diseases associated with the activation of STAT3 protein.
摘要翻译： 由式（I）表示的杂环衍生物或其药学上可接受的盐或立体异构体，其对STAT3蛋白质的活化具有抑制作用，并且可用于预防或治疗与STAT3蛋白质的活化有关的疾病。
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公开(公告)号：EP3461825A1
公开(公告)日：2019-04-03
申请号：EP18180710.8
申请日：2012-09-28
发明人： HO, Pil Su , YOON, Dong Oh , HAN, Sun Young , LEE, Won Il , KIM, Jung Sook , PARK, Woul Seong , AHN, Sung Oh , KIM, Hye Jung
IPC分类号： C07D471/14 , A61K31/4985 , A61P29/00 , A61P37/08 , A61P35/00 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention relates to novel heterocyclic compounds useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.
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公开(公告)号：EP2760865A2
公开(公告)日：2014-08-06
申请号：EP12834688.9
申请日：2012-09-28
发明人： HO, Pil Su , YOON, Dong Oh , HAN, Sun Young , LEE, Won Il , KIM, Jung Sook , PARK, Woul Seong , AHN, Sung Oh , KIM, Hye Jung
IPC分类号： C07D471/14 , A61K31/4985 , A61P29/00 , A61P37/08 , A61P35/00
CPC分类号： C07D471/14 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention relates to novel heterocyclic compounds useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.
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