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公开(公告)号：EP3189063A4
公开(公告)日：2018-02-21
申请号：EP15838655
申请日：2015-09-01
发明人： GRUBBS ROBERT H , STOLZ BRIAN M , TOUTOV ANTON , LIU WENBO , BETZ KERRY
CPC分类号： C07F7/0827 , C07F17/02 , C07J1/0096 , C07J7/0005 , C07J51/00 , C07J75/00
摘要： The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl C—H bond, with a mixture of at least one organosilane and an alkali metal hydroxide, alkali metal alkoxide, or alkali metal hydride under conditions sufficient to form a silylated terminal alkynyl moiety. The methods are operable in the presence or substantially absence of transition-metal compounds. The systems associated with these methods are also disclosed.
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公开(公告)号：EP3177630A4
公开(公告)日：2018-03-07
申请号：EP15829701
申请日：2015-08-05
发明人： STOLTZ BRIAN M , GRUBBS ROBERT H , FEDOROV ALEXEY , TOUTOV ANTON , LIU WENBO , BETZ KERRY
IPC分类号： C07F7/08 , C07D209/04 , C07D209/12 , C07D333/50 , C07D333/76 , C07D471/04 , C07F7/02
CPC分类号： C07F7/0801 , C07D209/12 , C07F7/0827 , C07F7/0832
摘要： The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including hydroxide, especially KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.
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