公开(公告)号：EP3169810A4

公开(公告)日：2018-03-21

申请号：EP15821344

申请日：2015-07-17

Applicant: CALIFORNIA INST OF TECHN

Inventor： CAI LONG ,  COSKUN AHMET

IPC: C12Q1/68 ,  G01N21/64 ,  G01N33/58 ,  G01N33/92 ,  G06T7/00

CPC classification number: G06F19/12 ,  C40B30/02 ,  G06F19/26

Abstract: Disclosed herein are methods and systems for analyzing visual data from multiple rounds of hybridization interactions where the same molecular target is detected by probes with different detectable labels. In particular, disclosed herein are methods and systems for analyzing sequential hybridization images for molecular profiling, where the images are obtained using multiplex fluorescence in situ hybridization (FISH).

公开(公告)号：EP2992115A4

公开(公告)日：2016-12-14

申请号：EP14795452

申请日：2014-04-30

Applicant: CALIFORNIA INST OF TECHN

Inventor： CAI LONG ,  LUBECK ERIC ,  ZHIYENTAYEV TIMUR ,  COSKUN AHMET ,  HE TING-FANG ,  SOHN CHANG HO ,  SHAH SHEEL

IPC: C12Q1/68

CPC classification number: C12Q1/6841 ,  C12N15/1065 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2201/068 ,  G01N2201/10 ,  G02B21/06 ,  G02B21/16 ,  C12Q2537/143 ,  C12Q2565/102 ,  C12Q2565/601

Abstract: The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci.

Abstract translation: 本发明尤其提供了用于在细胞，组织，器官或生物体中检测和/或定量核酸的技术。 在一些实施方案中，通过顺序条码，本发明提供了用于大量目标如转录物和/或DNA基因座的高通量分析的方法。