公开(公告)号：EP2555753A4

公开(公告)日：2013-10-16

申请号：EP11766746

申请日：2011-04-07

申请人： CALIFORNIA INST OF TECHN

发明人： SHEN YUE ,  MAZMANIAN SARKIS K

IPC分类号： A61K9/133 ,  A61K9/127 ,  A61K38/16 ,  A61K39/395 ,  A61P1/00 ,  A61P29/00

CPC分类号： A61K31/715 ,  A23L33/10 ,  A61K9/0065 ,  A61K9/10 ,  A61K39/0216 ,  A61K47/6901 ,  A61K2039/542 ,  A61K2039/55555 ,  A61K2039/55583 ,  A61K2039/57 ,  A61K2039/58 ,  C08B37/006 ,  C12N5/0637 ,  G01N33/505 ,  G01N2333/5428

摘要： PSA is delivered to the host by outer membrane vesicles (OMVs), secretion structures that target bacterial molecules to host cells. Purified OMVs direct the in vitro differentiation of functional Tregs with potent suppressive activity in a PSA dependent manner. Treatment of animals with OMVs containing PSA prevents experimental colitis and suppresses pro-inflammatory cytokine responses in the gut, and indicate that compositions, medicaments, and methods useful for the treatment of inflammation, and more particularly, inflammatory bowel diseases.

摘要翻译： PSA被传递到主机通过外膜囊泡（OMV），分泌的结构做了目标细菌分子对宿主细胞。 纯化的OMV引导功能的Treg的体外分化用在PSA依赖性方式有效的抑制活性。 动物OMV含有PSA的处理防止实验性结肠炎，抑制促炎细胞因子应答中的井，和表示没有组合物，药物，以及用于治疗炎症的有用的方法，并且更特别地，炎症性肠疾病。

公开(公告)号：EP2624863A4

公开(公告)日：2014-04-02

申请号：EP11831629

申请日：2011-10-06

申请人： CALIFORNIA INST OF TECHN

发明人： MAZMANIAN SARKIS K ,  PATTERSON PAUL H ,  CHOW JANET ,  HSIAO ELAINE ,  MCBRIDE SARA

IPC分类号： A61K39/02

CPC分类号： A61K35/741 ,  A61K2035/11

摘要： Provided is a method and a composition for improving behavioral performance in an individual comprising identifying an individual in need of treatment, and providing such an individual a composition comprising bacteria within the genus Bacteroides.

公开(公告)号：EP3212003A4

公开(公告)日：2018-05-30

申请号：EP15855218

申请日：2015-10-28

申请人： CALIFORNIA INST OF TECHN

发明人： HSIAO ELAINE ,  WU WEI-LI ,  MAZMANIAN SARKIS K ,  PATTERSON PAUL H

IPC分类号： A61K35/741 ,  A61P25/00 ,  A61P25/18 ,  C12Q1/68

CPC分类号： A61K35/741 ,  A61K9/0053 ,  C12Q1/6883

摘要： Some embodiments include probiotics for use in treatment of one or more autism spectrum disorder (ASD) or epilepsy in a subject in need thereof. The probiotics can comprise Bacteroides bacteria (e.g., B. fragilis). In some embodiments, the subject is identified in need of treatment ASD or epilepsy based a combination of behavioral symptoms and optional genetic markers. Upon treatment, one or more ASD-related behaviors are improved in the subject.

公开(公告)号：EP2890808A4

公开(公告)日：2016-09-28

申请号：EP13832132

申请日：2013-08-28

申请人： CALIFORNIA INST OF TECHN

发明人： HSIAO ELAINE ,  MAZMANIAN SARKIS K ,  PATTERSON PAUL H ,  MCBRIDE SARA

IPC分类号： C12Q1/04 ,  A61K35/37 ,  A61K35/74 ,  A61K35/741 ,  A61P25/00 ,  C07K16/18 ,  G01N33/68

CPC分类号： A61K39/3955 ,  A61K35/74 ,  A61K35/741 ,  A61K2039/505 ,  C07K16/18 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/7076 ,  G01N2800/7085

摘要： Disclosed herein are compositions, systems, and methods for diagnosing and treatment of subjects suffering from anxiety, autism spectrum disorder (ASD), or a pathological condition with one or more of the symptoms of ASD.

公开(公告)号：EP2571982A4

公开(公告)日：2014-01-01

申请号：EP11784368

申请日：2011-05-20

申请人： CALIFORNIA INST OF TECHN

发明人： ROUND JUNE L ,  MAZMANIAN SARKIS K

IPC分类号： C12N5/0783 ,  A61K35/12 ,  A61K39/00

CPC分类号： A61K39/0008 ,  A61K35/12 ,  A61K2039/5158 ,  A61K2039/6087 ,  C12N5/0637 ,  C12N2501/90

摘要： Antigen specific regulatory T cells are described and related compositions, methods and systems. Methods to generate an antigen specific anti-inflammatory regulatory T cell is provided, the method comprising contacting either a T cell or an antigen presenting cell with a zwitterionic polysaccharide conjugated to the antigen for a time and under condition to generate an antigen specific regulatory T cell that is capable of inhibiting a pro-inflammatory response against the antigen.

公开(公告)号：EP3212207A4

公开(公告)日：2018-06-13

申请号：EP15856096

申请日：2015-10-28

申请人： CALIFORNIA INST OF TECHN

发明人： BAILEY ANTOINETTE ,  MAZMANIAN SARKIS K ,  PATTERSON PAUL H

IPC分类号： A61K35/741 ,  A61P25/00 ,  A61P25/18

CPC分类号： A61K35/741 ,  A61K35/74

摘要： Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The subject in need thereof can have a gut microbiota signature characteristic of an adult. The bacterial species can include Bacteroides (e.g., B. fragilis, B. thetaiomtaomicron, and/or B. vulgatus), and/or Enterococcus (e.g., E. faecalis, E. faecium, E. hirae, E. avium, E. durans, E. gallinarum, or E. casseliflavus). Upon treatment, one or more ASD-related behaviors can be improved in the subject.

公开(公告)号：EP3212289A4

公开(公告)日：2018-05-16

申请号：EP15855495

申请日：2015-10-28

申请人： CALIFORNIA INST OF TECHN

发明人： HSIAO ELAINE ,  MCBRIDE SARA ,  MAZMANIAN SARKIS K ,  PATTERSON PAUL H

IPC分类号： A61P25/18 ,  A61K35/74

CPC分类号： A61K35/744 ,  A61K35/74 ,  A61K2035/115 ,  Y02A50/473 ,  A61K2300/00

摘要： Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The bacterial species can include Bacteroides (e.g., B. fragilis, B. thetaiomtaomicron, and/or B. vulgatus), and/or Enterococcus (e.g., E. faecalis, E. faecium, E. hirae, E. avium, E. durans, E. gallinarum, or E. casseliflavus). Upon treatment, one or more ASD-related behaviors can be improved in the subject.

公开(公告)号：EP2994161A4

公开(公告)日：2017-01-11

申请号：EP14795204

申请日：2014-05-08

申请人： CALIFORNIA INST OF TECHN

发明人： MAZMANIAN SARKIS K ,  LEE YUNKYUNG

IPC分类号： A61K39/02 ,  A61K31/59 ,  A61K31/715 ,  A61K35/741 ,  A61P35/00 ,  C07H13/00 ,  G01N33/00

CPC分类号： A61K35/741 ,  A61K31/59 ,  A61K31/715 ,  A61K2300/00

摘要： Methods are provided herein for preventing, delaying the onset of or reducing the progression of colorectal tumorigenesis in a subject identified as at risk of colorectal tumorigenesis, comprising adjusting the composition of gut microbiota in the subject via administering to the subject a composition comprising Bacteroides bacteria or administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising zwitterionic polysaccharide (ZPS). In another aspect, methods are provided for treating or ameliorating a colorectal cancer in a subject, comprising adjusting the composition of gut microbiota in the subject having the colorectal cancer. In a further aspect, methods are provided for relieving gastrointestinal (GI) distress of a subject having a colorectal condition, comprising: determining the colorectal condition of the subject; and relieving GI distress in the subject by adjusting the composition of gut microbiota in the subject.

公开(公告)号：EP2422200A4

公开(公告)日：2013-02-27

申请号：EP10767863

申请日：2010-04-23

申请人： CALIFORNIA INST OF TECHN

发明人： ROUND JUNE L ,  SHEN YUE ,  MAZMANIAN SARKIS K

IPC分类号： G01N33/569 ,  C07K14/52 ,  C12N5/0783 ,  G01N33/68

CPC分类号： G01N33/505 ,  A01K2227/101 ,  A01K2267/02 ,  A61K35/741 ,  A61K35/742 ,  A61K2035/115 ,  G01N33/5023

摘要： A method and system is presented for screening bacteria, products purified or made by bacteria and/or other bacterial substance for anti-inflammatory ability.

摘要翻译： 提出了用于筛选细菌，由细菌和/或其他细菌物质纯化或制成的抗炎能力的产品的方法和系统。