公开(公告)号：EP4426318A1

公开(公告)日：2024-09-11

申请号：EP22890798.6

申请日：2022-11-03

申请人： Orca Biosystems, Inc.

发明人： FERNHOFF, Nathaniel ,  DIMOV, Ivan ,  YIN, Catherine ,  KILLIAN, Scott ,  MARMELSTEIN, Alan

IPC分类号： A61K35/12 ,  A61K35/17 ,  A61P35/00 ,  A61P37/06 ,  A61K31/10 ,  A61K31/396 ,  A61K31/7076

CPC分类号： A61P35/00 ,  A61K35/17 ,  C12N5/0637 ,  A61K31/436

公开(公告)号：EP4388097A1

公开(公告)日：2024-06-26

申请号：EP22773539.6

申请日：2022-09-09

申请人： UCL Business Ltd ,  Genovese, Pietro

发明人： FOX, Thomas ,  MORRIS, Emma ,  BOOTH, Claire ,  HOUGHTON, Ben ,  GENOVESE, Pietro

IPC分类号： C12N15/113

CPC分类号： C12N15/1138 ,  C12N2310/2020170501 ,  C12N5/0636 ,  C12N2510/0020130101 ,  C12N9/22 ,  C07K14/47 ,  C12N5/0637 ,  C12N2750/1414320130101 ,  A61K35/28 ,  C07K14/4702 ,  C07K14/70521 ,  A61P37/06 ,  A61K39/464411 ,  A61K2239/3120230501 ,  A61K2239/3820230501 ,  A61K39/4611

公开(公告)号：EP4352209A1

公开(公告)日：2024-04-17

申请号：EP22820882.3

申请日：2022-06-07

申请人： The Methodist Hospital ,  Coya Therapeutics, Inc.

发明人： APPEL, Stanley, Hersh ,  THONHOFF, Jason, Robert ,  BEERS, David, Robert ,  THOME, Aaron, Drew ,  ZHAO, Weihua ,  BERMAN, Howard

IPC分类号： C12N5/0783 ,  A61K35/17 ,  A61K39/395

CPC分类号： C07K16/2809 ,  C07K16/2818 ,  C12N5/0637 ,  C12N2501/51520130101 ,  C12N2501/5120130101 ,  C12N2501/230220130101 ,  A61K35/39 ,  A61K39/46433 ,  A61K39/4611 ,  A61K39/4621

公开(公告)号：EP3759215B1

公开(公告)日：2024-04-17

申请号：EP19709008.7

申请日：2019-03-01

IPC分类号： C12N5/0783

CPC分类号： C12N5/0637 ,  C12N2501/51520130101 ,  C12N2501/5120130101 ,  C12N2501/230220130101 ,  C12N5/0636

公开(公告)号：EP3380197A1

公开(公告)日：2018-10-03

申请号：EP16869273.9

申请日：2016-11-23

申请人： President and Fellows of Harvard College

发明人： SAGE, Peter, T. ,  SHARPE, Arlene, H.

IPC分类号： A61P37/00 ,  A61K39/395 ,  A61K39/00

CPC分类号： C12N5/0637 ,  A61K39/39 ,  A61K39/395 ,  A61K2039/515 ,  A61K2039/5158 ,  A61K2039/55511 ,  A61K2039/55522 ,  A61K2039/55527 ,  C07K16/248 ,  C12N2501/2302 ,  C12N2501/2306 ,  C12N2501/2321 ,  C12N2501/515 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/392 ,  Y02A50/41 ,  Y02A50/412

摘要： The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses and the use of those methods in the treatment of diseases or conditions such as viral, bacterial, pathogenic, or fungal infections or cancer. Such methods provide for boosting of antibody production through the use of IL-21 to overcome TFR cell suppression of antibody production.

公开(公告)号：EP3365435A1

公开(公告)日：2018-08-29

申请号：EP16788382.6

申请日：2016-10-20

申请人： FUJIFILM Cellular Dynamics, Inc.

发明人： YU, Junying ,  VODYANYK, Maksym, A. ,  SASAKI, Jeffrey ,  RAJESH, Deepika ,  BURTON, Sarah, A.

IPC分类号： C12N5/0789

CPC分类号： C12N5/0636 ,  C12N5/0635 ,  C12N5/0637 ,  C12N5/0638 ,  C12N5/0639 ,  C12N5/0646 ,  C12N5/0647 ,  C12N15/85 ,  C12N15/86 ,  C12N2500/38 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/22 ,  C12N2501/2303 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/25 ,  C12N2501/26 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2501/727 ,  C12N2501/998 ,  C12N2501/999 ,  C12N2506/025 ,  C12N2506/03 ,  C12N2506/09 ,  C12N2506/11 ,  C12N2506/45 ,  C12N2510/00 ,  C12N2533/50 ,  C12N2840/20

摘要： Provided herein are methods for the efficient in vitro differentiation of somatic cell-derived pluripotent stem cells to hematopoietic precursor cells, and the further differentiation of the hematopoietic precursor cells into immune cells of various myeloid or lymphoid lineages, particularly T cells, NK cells, and dendritic cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the hematopoietic precursor cells.

公开(公告)号：EP3365433A1

公开(公告)日：2018-08-29

申请号：EP16788383.4

申请日：2016-10-20

申请人： FUJIFILM Cellular Dynamics, Inc.

发明人： VODYANYK, Maksym, A. ,  ZHANG, Xin ,  BRANDL, Andrew, J. ,  RAJESH, Deepika ,  SWANSON, Bradley ,  MUNN, Christie ,  BURTON, Sarah, A. ,  WANG, Wen, Bo

IPC分类号： C12N5/0783 ,  C12N5/0784 ,  C12N5/0789

CPC分类号： C12N5/0636 ,  C12N5/0635 ,  C12N5/0637 ,  C12N5/0638 ,  C12N5/0639 ,  C12N5/0646 ,  C12N5/0647 ,  C12N15/85 ,  C12N15/86 ,  C12N2500/38 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/22 ,  C12N2501/2303 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/25 ,  C12N2501/26 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2501/727 ,  C12N2501/998 ,  C12N2501/999 ,  C12N2506/025 ,  C12N2506/03 ,  C12N2506/09 ,  C12N2506/11 ,  C12N2506/45 ,  C12N2510/00 ,  C12N2533/50 ,  C12N2840/20

摘要： Provided herein are methods for the efficient in vitro differentiation of somatic cell-derived pluripotent stem cells to hematopoietic precursor cells, and the further differentiation of the hematopoietic precursor cells into immune cells of various myeloid or lymphoid lineages, particularly T cells, NK cells, and dendritic cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the hematopoietic precursor cells.

公开(公告)号：EP3347452A1

公开(公告)日：2018-07-18

申请号：EP16769882.8

申请日：2016-09-06

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Universite de Nantes ,  Centre Hospitalier Universitaire De Nantes

发明人： GUILLONNEAU, Carole ,  ANEGON, Ignacio ,  BEZIE, Séverine

IPC分类号： C12N5/0783

CPC分类号： C12N5/0637 ,  C12N2501/2302 ,  C12N2501/2315 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/727 ,  C12N2501/999 ,  G01N33/505 ,  G01N2800/245 ,  G01N2800/60

摘要： Disclosed is a new subpopulation of CD8+CD45RClow Tregs, namely IFNγ+IL-10+IL-34+ secreting population of CD8+CD45RClow Treg cells, methods for their isolation and expansion and their use as drug, more particularly for immunotherapy as well as biomarker

公开(公告)号：EP2893005B1

公开(公告)日：2018-06-13

申请号：EP13835382.6

申请日：2013-09-09

申请人： National Health Research Institutes

发明人： YEN, Lin-Ju ,  LIU, Ko-Jiunn ,  SYTWU, Huey-Kang

IPC分类号： C12N5/0783

CPC分类号： C12N5/0636 ,  C12N5/0637 ,  C12N2501/12

摘要： The present invention develops a straightforward and rapid method for generating immunomodulatory cells from peripheral mononuclear cells, comprising treating peripheral mononuclear cells with a hepatocyte growth factor (HGF) to induce differentiation of the peripheral mononuclear cells into immunomodulatory leukocytes. The present invention also provides an immunomodulatory cell prepared according to this method. The present invention further provides a method for treating a disease caused by abnormal immune response comprising administering a HGF to a patient exhibiting the disease, inducing the patient's peripheral mononuclear cells to differentiate into immunomodulatory leukocytes, and modulating the abnormal immune response.

公开(公告)号：EP2405929B1

公开(公告)日：2018-06-06

申请号：EP10751363.2

申请日：2010-03-10

申请人： Promedior Inc.

发明人： MURRAY, Lynne, Anne

IPC分类号： A61K38/17 ,  A61K39/00 ,  C12N5/00 ,  A61P11/06 ,  A61P37/00

CPC分类号： A61K38/1841 ,  A61K38/1716 ,  A61K38/20 ,  A61K2035/122 ,  C12N5/0637 ,  C12N5/0648 ,  C12N2501/998 ,  A61K2300/00

摘要： The present invention provides methods and compositions for expanding T regulatory cells ex vivo or in vivo using one or more SAP agonists. The methods and compositions are useful in the treatment of autoimmune diseases and in preventing foreign graft rejection.