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16 条记录 (耗时 0.014 秒)

    NANOELECTROMECHANICAL DEVICE FOR BIOCHEMICAL ANALYSIS
    3.
    发明授权
    NANOELECTROMECHANICAL DEVICE FOR BIOCHEMICAL ANALYSIS 有权
    NANO的机电设备实施生化分析

    公开(公告)号：EP1325302B1

    公开(公告)日：2006-10-11

    申请号：EP01964587.8

    申请日：2001-08-09

    申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

    发明人： ROUKES, Michael, L. ,  FRASER, Scott, E. ,  SOLOMAN,Jerry E. ,  CROSS,Michael C.

    IPC分类号： B81B7/02 ,  G01N33/543 ,  B81B3/00

    CPC分类号： G01N29/036 ,  B82Y5/00 ,  B82Y35/00 ,  G01N33/54373 ,  G01N2291/0257

    摘要： A biofunctionalized nanoelectromechanical device (BioNEWS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEWS device during a binding event is provided. The biofunctionalized nanoelctromechanical device according to the invention generally comprises a nanomechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the machanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalzed nanoelectromechanical devices and a method for utilizing the biofunctionalized nanelectromechanical device of the present invention are also provided.

    CELL-SPECIFIC GENE DELIVERY VEHICLES
    4.
    发明公开
    CELL-SPECIFIC GENE DELIVERY VEHICLES 失效
    细胞特异性基因递送载体

    公开(公告)号：EP0788374A2

    公开(公告)日：1997-08-13

    申请号：EP95939875.0

    申请日：1995-10-11

    申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

    发明人： KAYYEM, Jon, F. ,  MEADE, Thomas, J. ,  FRASER, Scott, E.

    IPC分类号： C12N15 ,  A61K38 ,  A61K45 ,  A61K47 ,  A61K48 ,  A61K49 ,  A61K51 ,  A61P35

    CPC分类号： A61K49/146 ,  A61K47/645 ,  A61K49/085 ,  Y10S977/808 ,  Y10S977/927 ,  Y10S977/93

    摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and physiological agents, including contrast agents and therapeutic agents, are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.

    OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEM WITH IMPROVED MOTION CONTRAST
    8.
    发明公开
    OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEM WITH IMPROVED MOTION CONTRAST 审中-公开
    SYSTEM FOR光学相干断层扫描（OCT）具有改进的运动CONTRAST

    公开(公告)号：EP3102091A1

    公开(公告)日：2016-12-14

    申请号：EP15747055.0

    申请日：2015-02-04

    申请人： University of Southern California ,  California Institute of Technology

    发明人： FINGLER, Jeffrey, P. ,  FRASER, Scott, E.

    IPC分类号： A61B3/10

    CPC分类号： A61B3/0025 ,  A61B3/0041 ,  A61B3/102 ,  A61B3/1233 ,  A61B5/7203 ,  G01B9/02076 ,  G01B9/02091 ,  G01B2290/65

    摘要： This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system with improved motion contrast. This disclosure particularly relates to motion contrast methods for such OCT systems. The OCT system of this disclosure may have a configuration that scans a physical object, which has a surface and a depth, with a beam of light that has a beam width and a direction; acquires OCT signals from the scan; forms at least one A-scan using the acquired OCT signals; forms at least one B-scan cluster set using the acquired OCT signals that includes at least two B-scan clusters that each include at least two B-scans. The B-scans within each B-scan cluster set are parallel to one another and parallel to the direction of the beam of light. The OCT system may have a configuration that calculates OCT motion contrast using the at least one B-scan cluster set. This OCT system may form and display an image of the physical object.

    ACTIVE NEMS ARRAYS FOR BIOCHEMICAL ANALYSES
    9.
    发明公开
    ACTIVE NEMS ARRAYS FOR BIOCHEMICAL ANALYSES 有权
    NANO的机电设备实施生化分析

    公开(公告)号：EP1325302A2

    公开(公告)日：2003-07-09

    申请号：EP01964587.8

    申请日：2001-08-09

    申请人： California Institute of Technology

    发明人： ROUKES, Michael, L. ,  FRASER, Scott, E. ,  SOLOMAN,Jerry E. ,  CROSS,Michael C.

    IPC分类号： G01N15/00

    CPC分类号： G01N29/036 ,  B82Y5/00 ,  B82Y35/00 ,  G01N33/54373 ,  G01N2291/0257

    摘要： A biofunctionalized nanoelectromechanical device (BioNEWS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEWS device during a binding event is provided. The biofunctionalized nanoelctromechanical device according to the invention generally comprises a nanomechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the machanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalzed nanoelectromechanical devices and a method for utilizing the biofunctionalized nanelectromechanical device of the present invention are also provided.