公开(公告)号：EP1845942A1

公开(公告)日：2007-10-24

申请号：EP05818606.5

申请日：2005-12-09

申请人： CAMURUS AB ,  Goddard, Christopher

发明人： JOABSSON, Fredrik, Camurus AB ,  JOHNSSON, Markus, Camurus AB ,  TIBERG, Fredrik, Camurus AB

IPC分类号： A61K9/10 ,  A61K9/06 ,  A61K9/12

CPC分类号： A61K9/0014 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/0063 ,  A61K9/12 ,  A61K9/1274 ,  A61K9/7015 ,  A61K45/06

摘要： The present invention relates to compositions forming a low viscosity mixture of: a) at least one diacyl glycerol; b) at least one phosphatidyl choline; c) at least one oxygen containing organic solvent; d) at least one GnRH analogue; Wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention further relates to methods of treatment comprising administration of such compositions, pre-filled administration devices and kits containing the formulations.

公开(公告)号：EP1682091B1

公开(公告)日：2017-03-29

申请号：EP04798419.0

申请日：2004-11-05

申请人： CAMURUS AB

发明人： JOABSSON, Fredrik, Camurus AB ,  TIBERG, Fredrik, Camurus AB

IPC分类号： A61K9/127 ,  A61K38/11 ,  A61K38/23 ,  A61K38/31

CPC分类号： A61K38/11 ,  A61K9/1274 ,  A61K38/23 ,  A61K38/31 ,  Y10S514/937 ,  Y10S514/964 ,  Y10T428/29 ,  Y10T428/2982

公开(公告)号：EP1713446A2

公开(公告)日：2006-10-25

申请号：EP05701965.5

申请日：2005-01-21

申请人： CAMURUS AB ,  Goddard, Christopher

发明人： JOHNSSON, Markus, Camurus AB ,  TIBERG, Fredrik, Camurus AB

IPC分类号： A61K9/127 ,  A61K38/11

CPC分类号： A61K9/1274

摘要： The present invention provides a particulate composition including; a) at least 50 % of at least one structure forming amphiphile, b) 0 to 40 % of at least one structure swelling amphiphile, and c) 2 to 20 % of at least one dispersion stabilising polymeric amphiphile, where all parts are by weight relative to the sum of the weights of a+b+c and wherein the composition comprises non-lamellar particles or forms non-lamellar particles when contacted with an aqueous fluid. Where component b) is 0 % then component a) comprises at least two structure forming amphiphiles. The invention also provides pharmaceutical compositions of the compositions and kits containing the compositions for establishing a pharmaceutical formulation of an active agent.

公开(公告)号：EP1670436A2

公开(公告)日：2006-06-21

申请号：EP04768511.0

申请日：2004-09-17

申请人： CAMURUS AB ,  Goddard, Chris

发明人： TIBERG, Fredrik, Camurus AB ,  BARAUSKAS, Justas ,  LARSSON, Kare, Camurus AB

IPC分类号： A61K9/127

CPC分类号： A61K9/1274 ,  A61K9/1075

摘要： The invention provides a composition suitable for administration to a mammalian, particularly human, subject wherein the composition comprises an active agent and an amphilic component (containing at least one amphiphile) wherein at least a portion of the amphiphilic component is an ether-linked lipid and wherein the composition includes a non-lamellar phase, preferably in the form of particles, or forms a non-lamellar phase on contact with an aqueous liquid. The aqueous liquid may be a body fluid. The invention also provides pharmaceutical and cosmetic formulations comprising the compositions and methods for their formation.

公开(公告)号：EP1663468B1

公开(公告)日：2008-10-15

申请号：EP04767990.7

申请日：2004-08-04

申请人： CAMURUS AB

发明人： JOABSSON, Fredrik, Camurus AB ,  TIBERG, Fredrik, Camurus AB ,  JOHNSSON, Markus, Camurus AB

IPC分类号： B01J13/00 ,  B01J13/02

CPC分类号： B01J13/02 ,  A61K9/5089 ,  B01J13/00

摘要： The present invention provides a method for the production of amphiphile particles having incorporated therein at least one active agent. The method comprises forming a dispersion of particles comprising at least one amphiphilic structuring agent in a solution of at least one active agent, heating said dispersion to an elevated temperature, followed by cooling to around ambient temperature. The loading provided thereby is typically at least 130 % of the loading provided by equilibration of the particles in a solution of active agent. The invention also provides corresponding amphiphile particles.

公开(公告)号：EP1682091A1

公开(公告)日：2006-07-26

申请号：EP04798419.0

申请日：2004-11-05

申请人： CAMURUS AB ,  Joabsson, Fredrik

发明人： JOABSSON, Fredrik, Camurus AB ,  TIBERG, Fredrik, Camurus AB

IPC分类号： A61K9/127 ,  A61K38/00 ,  A61K38/11 ,  A61K38/23 ,  A61K38/31

CPC分类号： A61K38/11 ,  A61K9/1274 ,  A61K38/23 ,  A61K38/31 ,  Y10S514/937 ,  Y10S514/964 ,  Y10T428/29 ,  Y10T428/2982

摘要： The present invention relates to compositions containing at least one cationic peptide active agent, at least one neutral structure forming amphiphile, at least one anionic structure forming amphiphile and optionally at least one solvent wherein the composition is in the form of a non-lamellar phase structure and/or forms a nonlamellar phase structure on exposure to body fluids. The invention also relates to methods for protecting peptides from enzymic degredation in vivo and to compositions in which the peptide active agent is so protected.

公开(公告)号：EP1663468A1

公开(公告)日：2006-06-07

申请号：EP04767990.7

申请日：2004-08-04

申请人： CAMURUS AB

发明人： JOABSSON, Fredrik, Camurus AB ,  TIBERG, Fredrik, Camurus AB ,  JOHNSSON, Markus, Camurus AB

IPC分类号： B01J13/00 ,  B01J13/02

CPC分类号： B01J13/02 ,  A61K9/5089 ,  B01J13/00

摘要： The present invention provides a method for the production of amphiphile particles having incorporated therein at least one active agent. The method comprises forming a dispersion of particles comprising at least one amphiphilic structuring agent in a solution of at least one active agent, heating said dispersion to an elevated temperature, followed by cooling to around ambient temperature. The loading provided thereby is typically at least 130 % of the loading provided by equilibration of the particles in a solution of active agent. The invention also provides corresponding amphiphile particles.