公开(公告)号：EP1845942A1

公开(公告)日：2007-10-24

申请号：EP05818606.5

申请日：2005-12-09

申请人： CAMURUS AB ,  Goddard, Christopher

发明人： JOABSSON, Fredrik, Camurus AB ,  JOHNSSON, Markus, Camurus AB ,  TIBERG, Fredrik, Camurus AB

IPC分类号： A61K9/10 ,  A61K9/06 ,  A61K9/12

CPC分类号： A61K9/0014 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/0063 ,  A61K9/12 ,  A61K9/1274 ,  A61K9/7015 ,  A61K45/06

摘要： The present invention relates to compositions forming a low viscosity mixture of: a) at least one diacyl glycerol; b) at least one phosphatidyl choline; c) at least one oxygen containing organic solvent; d) at least one GnRH analogue; Wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention further relates to methods of treatment comprising administration of such compositions, pre-filled administration devices and kits containing the formulations.

公开(公告)号：EP1682091B1

公开(公告)日：2017-03-29

申请号：EP04798419.0

申请日：2004-11-05

申请人： CAMURUS AB

发明人： JOABSSON, Fredrik, Camurus AB ,  TIBERG, Fredrik, Camurus AB

IPC分类号： A61K9/127 ,  A61K38/11 ,  A61K38/23 ,  A61K38/31

CPC分类号： A61K38/11 ,  A61K9/1274 ,  A61K38/23 ,  A61K38/31 ,  Y10S514/937 ,  Y10S514/964 ,  Y10T428/29 ,  Y10T428/2982

公开(公告)号：EP1663468B1

公开(公告)日：2008-10-15

申请号：EP04767990.7

申请日：2004-08-04

申请人： CAMURUS AB

发明人： JOABSSON, Fredrik, Camurus AB ,  TIBERG, Fredrik, Camurus AB ,  JOHNSSON, Markus, Camurus AB

IPC分类号： B01J13/00 ,  B01J13/02

CPC分类号： B01J13/02 ,  A61K9/5089 ,  B01J13/00

摘要： The present invention provides a method for the production of amphiphile particles having incorporated therein at least one active agent. The method comprises forming a dispersion of particles comprising at least one amphiphilic structuring agent in a solution of at least one active agent, heating said dispersion to an elevated temperature, followed by cooling to around ambient temperature. The loading provided thereby is typically at least 130 % of the loading provided by equilibration of the particles in a solution of active agent. The invention also provides corresponding amphiphile particles.

公开(公告)号：EP1682091A1

公开(公告)日：2006-07-26

申请号：EP04798419.0

申请日：2004-11-05

申请人： CAMURUS AB ,  Joabsson, Fredrik

发明人： JOABSSON, Fredrik, Camurus AB ,  TIBERG, Fredrik, Camurus AB

IPC分类号： A61K9/127 ,  A61K38/00 ,  A61K38/11 ,  A61K38/23 ,  A61K38/31

CPC分类号： A61K38/11 ,  A61K9/1274 ,  A61K38/23 ,  A61K38/31 ,  Y10S514/937 ,  Y10S514/964 ,  Y10T428/29 ,  Y10T428/2982

摘要： The present invention relates to compositions containing at least one cationic peptide active agent, at least one neutral structure forming amphiphile, at least one anionic structure forming amphiphile and optionally at least one solvent wherein the composition is in the form of a non-lamellar phase structure and/or forms a nonlamellar phase structure on exposure to body fluids. The invention also relates to methods for protecting peptides from enzymic degredation in vivo and to compositions in which the peptide active agent is so protected.

公开(公告)号：EP1663468A1

公开(公告)日：2006-06-07

申请号：EP04767990.7

申请日：2004-08-04

申请人： CAMURUS AB

发明人： JOABSSON, Fredrik, Camurus AB ,  TIBERG, Fredrik, Camurus AB ,  JOHNSSON, Markus, Camurus AB

IPC分类号： B01J13/00 ,  B01J13/02

CPC分类号： B01J13/02 ,  A61K9/5089 ,  B01J13/00

摘要： The present invention provides a method for the production of amphiphile particles having incorporated therein at least one active agent. The method comprises forming a dispersion of particles comprising at least one amphiphilic structuring agent in a solution of at least one active agent, heating said dispersion to an elevated temperature, followed by cooling to around ambient temperature. The loading provided thereby is typically at least 130 % of the loading provided by equilibration of the particles in a solution of active agent. The invention also provides corresponding amphiphile particles.