公开(公告)号：EP0081949A1

公开(公告)日：1983-06-22

申请号：EP82306409.2

申请日：1982-12-02

申请人： CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED

发明人： Baldwin, Robert William The Univ. of Nottingham ,  Austin, Eric Bertram The Univ. of Nottingham ,  Embleton, Michale Jim The Univ. of Nottingham ,  Holmes, Christopher Harold The Univ. of Nottingham ,  Gunn, Barbara The Univ. of Nottingham

IPC分类号： C12N5/00 ,  C12N5/02 ,  G01N33/54 ,  G01N33/56 ,  A61K39/00

CPC分类号： C07K16/28

摘要： The present invention relates to an anti-rat liver antibody monoclone RL/23 clone 36 and has particular reference to an anti-rat liver monoclonal antibody adapted to detect an antigen associated with mammalian hepatocytes, but not with normal syngenetic cell types. The invention further includes a method of detecting the presence of absence of a mammalian hepatocyte antigen which comprises screening said hepatocyte against the antibody in accordance with the invention and assessing the degree of activity thereof. A preferred screening technique may be by means of immunoperoxidase staining techniques.

摘要翻译： 本发明涉及抗大鼠肝脏抗体单克隆RL / 23克隆36，并且具体参考适于检测与哺乳动物肝细胞相关的抗原但不与正常的同基因细胞类型相关的抗原的抗大鼠肝单克隆抗体。 本发明还包括检测哺乳动物肝细胞抗原不存在的方法，其包括根据本发明筛选所述肝细胞针对抗体并评估其活性程度。 优选的筛选技术可以是通过免疫过氧化物酶染色技术。