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公开(公告)号：EP2998313A4
公开(公告)日：2016-12-21
申请号：EP13884437
申请日：2013-10-25
申请人： CAREGEN CO LTD
发明人： CHUNG YOUNG JI , KIM EUN MI , LEE EUNG-JI , LEE TAE-HOON , LEE YOUNG-MIN
CPC分类号： C07K7/08 , A61K38/00 , C07K14/70521 , G01N33/5023 , G01N2333/4703 , G01N2333/70535 , G01N2500/02 , G01N2500/10
摘要： A peptide according to the present invention can perform a function identical or similar to the function of natural CTLA-4 and has an excellent degree of skin penetration due to a small size. The peptide according to the present invention effectively binds to antigen presenting cell surface proteins (CD80 and CD86) to inhibit activity of T cells and thus is capable of inhibiting the expression of inflammatory cytokines (for example, IL-2 and IFN-³). As a result, a composition comprising the peptide according to the present invention exhibits excellent effects in terms of preventing, treating, or improving Th1-mediated immune diseases. Therefore, the superior activity and stability of the peptide according to the present invention can be useful when applied to medicine, quasi-drugs, and cosmetics.
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公开(公告)号：EP3275891A4
公开(公告)日：2018-08-01
申请号：EP17730342
申请日：2017-02-06
申请人： CAREGEN CO LTD
发明人： CHUNG YONG JI , KIM EUN MI , LEE EUNG-JI , KIM JAN DI
CPC分类号： A61K38/005 , A61K8/64 , A61K38/02 , A61Q19/02 , C07K7/08
摘要： The present invention provides a peptide having skin-whitening activity. The peptide of the present invnetion exhibits an excellent skin whitening effect by inhibiting melanogenesis, inhibiting the activity of tyrosinase, inhibiting the expression of melanosis-involved factors, and inhibiting melanosome trasnfer. The peptide of the present invention has excellent skin permeability due to the the small size thereof. Excellent activity and stability of the foregoing peptide of the present invention can be very favorably applied to cosmetics.
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