公开(公告)号：EP4234078A2

公开(公告)日：2023-08-30

申请号：EP23164390.9

申请日：2018-04-05

申请人： CARNEGIE MELLON UNIVERSITY

发明人： Hudson, Andrew ,  Hinton, Thomas ,  Feinberg, Adam ,  Lee, Andrew

IPC分类号： B01J13/06 ,  B01J13/08 ,  B01J13/10 ,  A61K9/107 ,  A61K9/16 ,  A61K9/50 ,  A61L27/14 ,  A61L27/20 ,  A61L27/24 ,  A61L27/52

摘要： This document describes a process of producing gel microparticles, which are consistent in size and morphology. Through the process of coacervation, large volumes of gel microparticle slurry can be produced by scaling up reactor vessel size. Particles can be repeatedly dehydrated and rehydrated in accordance to their environment, allowing for the storage of particles in a non-solvent such as ethanol. Gel slurries exhibit a Bingham plastic behavior in which the slurry behaves as a solid at shear stresses that are below a critical value. Upon reaching the critical shear stress, the slurry undergoes a rapid decrease in viscosity and behaves as a liquid. The rheological behavior of these slurries can be adjusted by changing the compaction processes such as centrifugation force to alter the yield-stress. The narrower distribution and reduced size of these particles allows for an increase in FRESH printing fidelity.

公开(公告)号：EP4234078A3

公开(公告)日：2023-09-27

申请号：EP23164390.9

申请日：2018-04-05

申请人： CARNEGIE MELLON UNIVERSITY

发明人： Hudson, Andrew ,  Hinton, Thomas ,  Feinberg, Adam ,  Lee, Andrew

IPC分类号： B01J13/06 ,  B01J13/08 ,  B01J13/10 ,  A61K9/107 ,  A61K9/16 ,  A61K9/50 ,  A61L27/14 ,  A61L27/20 ,  A61L27/24 ,  A61L27/52

摘要： This document describes a process of producing gel microparticles, which are consistent in size and morphology. Through the process of coacervation, large volumes of gel microparticle slurry can be produced by scaling up reactor vessel size. Particles can be repeatedly dehydrated and rehydrated in accordance to their environment, allowing for the storage of particles in a non-solvent such as ethanol. Gel slurries exhibit a Bingham plastic behavior in which the slurry behaves as a solid at shear stresses that are below a critical value. Upon reaching the critical shear stress, the slurry undergoes a rapid decrease in viscosity and behaves as a liquid. The rheological behavior of these slurries can be adjusted by changing the compaction processes such as centrifugation force to alter the yield-stress. The narrower distribution and reduced size of these particles allows for an increase in FRESH printing fidelity.