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1.发明公开Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof 失效对表达甲胎蛋白的细胞具有特异性的腺病毒载体及其使用方法
公开(公告)号：EP1918380A2
公开(公告)日：2008-05-07
申请号：EP07023968.6
申请日：1998-03-03
申请人： CELL GENESYS, INC.
IPC分类号： C12N15/861
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C07K14/4715 , C12N15/63 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2830/008
摘要： Non-naturally occurring adenoviral vectors comprise a polynucleotide encoding an adenovirus death protein (ADP) polypeptide. The polynucleotide encoding ADP may be under transcriptional control of a cell-specific transcriptional regulatory element such as an α-fetoprotein transcriptional regulatory element.
摘要翻译： 非天然存在的腺病毒载体包含编码腺病毒死亡蛋白（ADP）多肽的多核苷酸。 编码ADP的多核苷酸可以处于细胞特异性转录调控元件例如α-胎蛋白转录调节元件的转录控制下。
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2.发明公开Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof 失效甲胎蛋白表达使用的细胞和方法为腺病毒载体
公开(公告)号：EP1918380A3
公开(公告)日：2008-08-06
申请号：EP07023968.6
申请日：1998-03-03
申请人： CELL GENESYS, INC.
IPC分类号： C12N15/861
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C07K14/4715 , C12N15/63 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2830/008
摘要： Non-naturally occurring adenoviral vectors comprise a polynucleotide encoding an adenovirus death protein (ADP) polypeptide. The polynucleotide encoding ADP may be under transcriptional control of a cell-specific transcriptional regulatory element such as an α-fetoprotein transcriptional regulatory element.
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