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公开(公告)号：EP1173569A1
公开(公告)日：2002-01-23
申请号：EP00927406.9
申请日：2000-04-17
IPC分类号： C12N15/12 , C07K14/705 , C12N15/62 , A61K38/17
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The invention relates to synthetic signalling molecules, which are based on sequences derived from primary signalling motifs such as immunoglobulin tyrosine receptor-based activation motifs (ITAMs). The use of such signalling molecules within chimeric receptor proteins allows one to tailor the level of intracellular signalling mediated by the chimeric receptor. Proteins containing, and nucleic acids encoding, such synthetic signalling molecules suitable for use in medicine, are described.
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公开(公告)号：EP1171596A1
公开(公告)日：2002-01-16
申请号：EP00925464.0
申请日：2000-04-17
IPC分类号： C12N15/12 , C07K14/705 , C12N15/62 , A61K31/70
CPC分类号： C07K14/705 , A61K48/00 , C07K14/7051 , C07K14/70521 , C07K14/70535 , C07K2319/00
摘要： The invention relates to nucleic acids encoding a synthetic transmembrane region as well as to membrane associated proteins containing these synthetic transmembrane regions. The design of the synthetic transmembrane region allows various properties of a protein, such as its level of expression, and relative response to ligand binding to be tailored as required for a specific purpose.
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