公开(公告)号：EP1546126B1

公开(公告)日：2007-11-21

申请号：EP03784619.3

申请日：2003-08-08

申请人： CENTRAL GLASS COMPANY, LIMITED

发明人： ISHII, Akihiro c/o Chemical Research Center ,  KANAI, Masatomi c/o Chemical Research Center ,  KURIYAMA, Yokusu c/o Chemical Research Center ,  YASUMOTO, Manabu c/o Chemical Research Center ,  INOMIYA, Kenjin c/o Chemical Research Center ,  OOTSUKA, Takashi c/o Chemical Research Center ,  UEDA, Koji c/o Chemical Research Center

IPC分类号： C07D317/16 ,  C07D317/22 ,  C07C49/84 ,  C07C45/59 ,  C07C45/42

CPC分类号： C07D317/22 ,  C07C43/315 ,  C07C45/57 ,  C07C45/59 ,  C07C45/60 ,  C07C49/84 ,  C07D317/16 ,  C07C49/80

摘要： A process for producing a brominated acetal (represented by the formula 3) includes (a) brominating a trifluoromethyl-substituted acetophenone by Br2 in the presence of an alkylene diol. It is optional to produce a trifluoromethyl-substituted 2-alkoxyacetophenone derivative (represented by the formula 9) by (b) reacting the brominated acetal with a metal alkoxide, thereby converting the brominated acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove an acetal group from the ether, thereby producing the 2-alkoxyacetophenone derivative. Alternatively, the 2-alkoxyacetophenone can be produced by (a) reacting a trifluoromethyl-substituted phenacyl halide with an acetalization agent, thereby converting the phenacyl halide into an acetal; (b) reacting the acetal with a metal alkoxide, thereby converting the acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove the acetal group from the ether.