公开(公告)号：EP1628769B1

公开(公告)日：2018-07-04

申请号：EP04742779.4

申请日：2004-05-19

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- ,  Institut Curie

发明人： VIOVY, Jean-Louis ,  FUTTERER, Claus ,  MINC, Nicolas, Davis ,  ROSSIER, Jean ,  CODARBOX, Jean-Hugues

IPC分类号： B01L3/00

CPC分类号： B01L3/502738 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00162 ,  B01J2219/00788 ,  B01J2219/00853 ,  B01J2219/00862 ,  B01J2219/00891 ,  B01J2219/0095 ,  B01L3/502715 ,  B01L2300/14 ,  B01L2400/0421 ,  B01L2400/0487 ,  Y10T137/4774 ,  Y10T137/479 ,  Y10T137/7303 ,  Y10T137/776 ,  Y10T137/7792

公开(公告)号：EP1628769A1

公开(公告)日：2006-03-01

申请号：EP04742779.4

申请日：2004-05-19

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Institut Curie

发明人： VIOVY, Jean-Louis ,  FUTTERER, Claus ,  MINC, Nicolas, Davis ,  ROSSIER, Jean ,  CODARBOX, Jean-Hugues

IPC分类号： B01L3/00

CPC分类号： B01L3/502738 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00162 ,  B01J2219/00788 ,  B01J2219/00853 ,  B01J2219/00862 ,  B01J2219/00891 ,  B01J2219/0095 ,  B01L3/502715 ,  B01L2300/14 ,  B01L2400/0421 ,  B01L2400/0487 ,  Y10T137/4774 ,  Y10T137/479 ,  Y10T137/7303 ,  Y10T137/776 ,  Y10T137/7792

摘要： The invention relates to a microfluidic device (1) comprising at least one micro-channel (2) connected at one end to an enclosed area (6), characterized in that it also comprises an inlet circuit (8) and an outlet circuit (9) connected to the enclosed area and between which the fluid can be discharged without any contact with the micro-channel, wherein at least one of said inlet and outlet circuits can be controlled in such a way that the pressure at the end of the micro-channel can be modified independently from the pressure at the other end of the micro-channel.

公开(公告)号：EP0586526A1

公开(公告)日：1994-03-16

申请号：EP92912278.0

申请日：1992-05-29

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： DODD, Robert, H. ,  POTIER, Pierre ,  DOISY, Xavier ,  ROSSIER, Jean ,  PRADO DE CARVALHO, Lia

IPC分类号： A61K31 ,  A61P25 ,  C07D471

CPC分类号： C07D471/04

摘要： L'invention concerne des dérivés des aza-6-indoles, ligands du récepteur des benzodiazépines ayant un effet agoniste inverse vis-à-vis des benzodiazépine de formule (I), R1 est H, alcoxyméthyle, ou un groupe (II), R2 est hydrocarbyloxy, R3, R4 est alkyle. L'invention concerne également des médicaments constitués de ces composés pour traiter notamment les troubles nerveux.

公开(公告)号：EP1474368A2

公开(公告)日：2004-11-10

申请号：EP03739533.2

申请日：2003-02-13

申请人： CNRS ,  Institut Curie

发明人： NASSOY, Pierre ,  POTIER, Marie-Claude ,  TALINI, M., Luc ,  GIBELIN, Nathalie ,  ROSSIER, Jean

IPC分类号： C07B61/00 ,  C07H21/00 ,  C07K1/04 ,  C12Q1/68

CPC分类号： B82Y30/00 ,  B01J2219/00274 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  C07B2200/11 ,  C07K1/1077 ,  C40B40/06 ,  C40B40/10

摘要： The invention relates to a method for production of an activated biochip for covalent fixing of oligonucleotide probes to a solid support by means of a spacer compound of the NHS-PEG-VS type and biochips produced by the above method. The invention further relates to methods for detection of nucleic acids in a sample or methods for screening compounds which may be specifically bound to oligonucleotide probes in which said biochips are used. The invention also relates to detection kits for, quantitative or qualitative analysis of nucleic acids in a sample, comprising said biochips and use of the above as affinity matrix for purification of nucleic acids, for sequencing nucleic acids, for the qualitative or quantitative analysis of the expression of genes or for the study and detection of genetic polymorphism.