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    CHEMICAL PRODUCTION MODULE AND DOSE SYNTHESIS CARD FOR PET BIOMARKER PRODUCTION SYSTEM
    6.
    发明公开
    CHEMICAL PRODUCTION MODULE AND DOSE SYNTHESIS CARD FOR PET BIOMARKER PRODUCTION SYSTEM 审中-公开
    化工生产模块和剂量合成卡的宠物生物标志物的生产系统

    公开(公告)号：EP2480258A1

    公开(公告)日：2012-08-01

    申请号：EP10819146.1

    申请日：2010-09-21

    申请人： McFarland, Aaron ,  ABT Molecular Imaging, Inc.

    发明人： NUTT, Ronald ,  GIAMIS, Anthony, M.

    IPC分类号： A61K51/00 ,  A61M3/00 ,  A61M36/14

    CPC分类号： A61K51/0491 ,  B01J19/004 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905

    摘要： A microfluidic radiopharmaceutical production system and process for synthesizing per run approximately one (1) to four (4) unit dose of a radiopharmaceutical biomarker for use in positron emission tomography (PET). The system includes a reaction vessel that receives a radioisotope from an accelerator or other radioisotope generator. Organic and aqueous reagents are introduced into the reaction vessel, and the mixture is heated to synthesize a solution of a pre-selected radiopharmaceutical. The radiopharmaceutical solution is passed through a solid phase extraction column and a filter for purification. The synthesis process reduces waste and allows for the production of radiopharmaceutical on an as-needed basis. The synthesis process allows for production on-site and close to the location where the unit dose will be administered to the patient, which reduces time between synthesis and administration, thereby minimizing the loss of active isotopes through decay and allowing the production of lesser amounts of radioisotopes overall.

    HALOGEN-SUBSTITUTED SACCHARIDE, METHOD FOR PRODUCING SAME, REACTION COMPOSITION OF SAME AND DEVICE FOR PRODUCING SAME
    8.
    发明公开
    HALOGEN-SUBSTITUTED SACCHARIDE, METHOD FOR PRODUCING SAME, REACTION COMPOSITION OF SAME AND DEVICE FOR PRODUCING SAME 审中-公开
    卤素取代糖，METHOD FOR ITS，反应其组成和生产器用于其

    公开(公告)号：EP2386562A1

    公开(公告)日：2011-11-16

    申请号：EP09837468.9

    申请日：2009-12-25

    申请人： National Institute of Advanced Industrial Science and Technology

    发明人： SATO, Masahiro ,  KAWANAMI, Hajime ,  MIZUKAMI, Fujio

    IPC分类号： C07H1/00 ,  A61K51/00 ,  B01J3/00 ,  B01J19/00 ,  B81B1/00 ,  C07H5/02

    CPC分类号： C07H5/02 ,  A61K51/0491 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00891 ,  C07B63/00 ,  C07H1/00 ,  Y02P20/544

    摘要： The present invention provides: a method for synthesizing a halogen-substituted saccharide from a leaving group-substituted saccharide in a short-time and continuously; a reaction composition; and a device for synthesis of same, i.e., the method being for synthesizing a halogen-substituted saccharide from a leaving group-substituted saccharide by a halogen-substituted saccharide synthesis reaction using a subcritical fluid or a supercritical fluid as the reaction solvent; the reaction composition of the same being an aqueous solution of halogen-substituted saccharide; and the device for synthesis being a device for producing the same, the method being for producing a halogen-substituted saccharide with a subcritical fluid or a supercritical fluid at a temperature of 100 to 400°C and a pressure of 0.1 to 40 MPa or a mixed solvent of aprotic organic solvent or inorganic solvent mixed therein as the reaction solvent, under a catalyst-free condition, by introducing the leaving group-substituted saccharide and the reaction solvent into a circulating-type high-temperature and high-pressure device to produce selectively a halogen-substituted saccharide at high yield, high selectivity, high speed and continuously, while reducing the amount of energy consumption and the amount of waste.

    摘要翻译： 本发明提供：一种方法，用于从在短时间和连续的离去基团的糖substituiertem合成卤素substituiertem糖类; 的反应组合物; 和的相同，即，该方法是用于通过使用亚临界流体或超临界流体作为反应溶剂卤素substituiertem糖合成反应从离去基团-substituiertem糖类合成卤素substituiertem糖合成的装置; 相同的被卤素substituiertem糖类的wässrige溶液的反应组合物; 和用于合成的设备是用于生产同样的装置中，该方法是用于制造卤素substituiertem糖类与亚临界流体或在100〜400℃的温度下的超临界流体和0.1至40MPa或压力 非质子有机溶剂或混入其中作为反应溶剂的无机溶剂的混合溶剂，无催化剂的条件下，通过引入离去基团，substituiertem糖类和反应溶剂到循环型高温和高压的装置，以产生 选择性卤素substituiertem糖类以高收率，高选择性，高的速度和连续地，同时降低能耗的量和废物的数量。