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公开(公告)号：EP1487484B1
公开(公告)日：2009-02-11
申请号：EP03727589.8
申请日：2003-03-14
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE LILLE II , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： GUILLET, Jean-Gérard , BOURGAULT-VILLADA, Isabelle , DUPUIS, Marion , GRAS MASSE, Hélène , BOUREL, Line , MELNYK, Oleg , JOLY, Pascal , BONNET, Dominique , MALINGUE, Frédéric , GRAND JEAN, Cyrille , GEORGES, Bertrand
CPC分类号： C07K14/005 , A61K39/385 , A61K2039/542 , A61K2039/55555 , A61K2039/6018 , A61K2039/627 , C12N2740/15022 , C12N2740/16022 , C12N2770/24222
摘要： The invention relates to the use of a mixture containing at least lipopeptides for vaccine production. Said lipopeptides comprise a peptide compound which has been bound in solution by means of a hydrazone linkage to at least one non-peptidic lipophilic carrier. The invention also relates to native sequences NS3 of the HCV.
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2.发明授权MICELLES MIXTES DE LIPOPEPTIDES POUR L'INDUCTION D'UNE REPONSE IMMUNITAIRE 有权MISCMICELLEN关闭脂肽诱导免疫应答
公开(公告)号：EP1035866B1
公开(公告)日：2006-05-17
申请号：EP98958314.1
申请日：1998-12-02
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT PASTEUR DE LILLE
发明人： GRAS-MASSE, Hélène , BOSSUS, Marc , LIPPENS, Guy , WIERUSZESKI, Jean-Michel , TARTAR, André , GUILLET, Jean-Gérard , BOURGAULT-VILLADA, Isabelle
CPC分类号： A61K39/015 , A61K9/1075 , A61K39/12 , A61K39/385 , A61K2039/55577 , A61K2039/6018 , A61K2039/70 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334 , Y02A50/412
摘要： The invention concerns mixed micelles or micro-aggregates for inducing an immune response containing at least: a first lipopeptide comprising a CTL epitope and at least a first lipid motif; and a second lipopeptide comprising at least an auxiliary T epitope and at least a lipid motif, whereof the type can be different from the first lipopeptide motif. Said micelles can be used as medicines and vaccines.
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3.发明公开
公开(公告)号：EP1487484A2
公开(公告)日：2004-12-22
申请号：EP03727589.8
申请日：2003-03-14
申请人： INSTITUT PASTEUR DE LILLE , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE LILLE II , INSTITUT NATIONAL DE LA SANTE ETDE LA RECHERCHE MEDICALE (INSERM) , SEDAC-Therapeutics (SOCIETE D'ETUDE ET DE DEVELOPPEMENT DES ANTIGENES COMBINATOIRES)
发明人： GUILLET, Jean-Gérard , BOURGAULT-VILLADA, Isabelle , DUPUIS, Marion , GRAS MASSE, Hélène , BOUREL, Line , MELNYK, Oleg , JOLY, Pascal , BONNET, Dominique , MALINGUE, Frédéric , GRAND JEAN, Cyrille , GEORGES, Bertrand
CPC分类号： C07K14/005 , A61K39/385 , A61K2039/542 , A61K2039/55555 , A61K2039/6018 , A61K2039/627 , C12N2740/15022 , C12N2740/16022 , C12N2770/24222
摘要： The invention relates to the use of a mixture containing at least lipopeptides for vaccine production. Said lipopeptides comprise a peptide compound which has been bound in solution by means of a hydrazone linkage to at least one non-peptidic lipophilic carrier. The invention also relates to native sequences NS3 of the HCV.
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