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1.发明公开
公开(公告)号：EP1487484A2
公开(公告)日：2004-12-22
申请号：EP03727589.8
申请日：2003-03-14
申请人： INSTITUT PASTEUR DE LILLE , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE LILLE II , INSTITUT NATIONAL DE LA SANTE ETDE LA RECHERCHE MEDICALE (INSERM) , SEDAC-Therapeutics (SOCIETE D'ETUDE ET DE DEVELOPPEMENT DES ANTIGENES COMBINATOIRES)
发明人： GUILLET, Jean-Gérard , BOURGAULT-VILLADA, Isabelle , DUPUIS, Marion , GRAS MASSE, Hélène , BOUREL, Line , MELNYK, Oleg , JOLY, Pascal , BONNET, Dominique , MALINGUE, Frédéric , GRAND JEAN, Cyrille , GEORGES, Bertrand
CPC分类号： C07K14/005 , A61K39/385 , A61K2039/542 , A61K2039/55555 , A61K2039/6018 , A61K2039/627 , C12N2740/15022 , C12N2740/16022 , C12N2770/24222
摘要： The invention relates to the use of a mixture containing at least lipopeptides for vaccine production. Said lipopeptides comprise a peptide compound which has been bound in solution by means of a hydrazone linkage to at least one non-peptidic lipophilic carrier. The invention also relates to native sequences NS3 of the HCV.
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2.发明公开PROCEDE DE COUPLAGE, EN SOLUTION, ENTRE UN PEPTIDE ET UN VECTEUR LIPOPHILE ET SES APPLICATIONS 有权PROCESS FOR IN之间的肽和亲脂性化合物溶液的离合器，及其用途
公开(公告)号：EP1315739A2
公开(公告)日：2003-06-04
申请号：EP01967454.8
申请日：2001-09-07
申请人： INSTITUT PASTEUR DE LILLEEtablissement Public , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： BONNET, Dominique , BOUREL, Line , MELNYK, Oleg
IPC分类号： C07K1/107 , A61K47/48 , C07C233/03 , C07D209/32 , A61K39/395
CPC分类号： C07D263/04 , A61K38/00 , A61K47/54 , C07C235/74 , C07K1/1077
摘要： The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, said coupling comprising a step which consists in producing a hydrazone bond between said peptide compound and said lipophilic vector. The invention also concerns lipophilic vectors for use in said method, lipopeptides obtained by said method, uses of said lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.
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公开(公告)号：EP1487484B1
公开(公告)日：2009-02-11
申请号：EP03727589.8
申请日：2003-03-14
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE LILLE II , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： GUILLET, Jean-Gérard , BOURGAULT-VILLADA, Isabelle , DUPUIS, Marion , GRAS MASSE, Hélène , BOUREL, Line , MELNYK, Oleg , JOLY, Pascal , BONNET, Dominique , MALINGUE, Frédéric , GRAND JEAN, Cyrille , GEORGES, Bertrand
CPC分类号： C07K14/005 , A61K39/385 , A61K2039/542 , A61K2039/55555 , A61K2039/6018 , A61K2039/627 , C12N2740/15022 , C12N2740/16022 , C12N2770/24222
摘要： The invention relates to the use of a mixture containing at least lipopeptides for vaccine production. Said lipopeptides comprise a peptide compound which has been bound in solution by means of a hydrazone linkage to at least one non-peptidic lipophilic carrier. The invention also relates to native sequences NS3 of the HCV.
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4.发明授权PROCEDE DE COUPLAGE, EN SOLUTION, ENTRE UN PEPTIDE ET UN VECTEUR LIPOPHILE ET SES APPLICATIONS 有权PROCESS FOR IN之间的肽和亲脂性化合物溶液的离合器，及其用途
公开(公告)号：EP1315739B1
公开(公告)日：2004-08-18
申请号：EP01967454.8
申请日：2001-09-07
申请人： INSTITUT PASTEUR DE LILLE Etablissement Public , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： C07K1/107 , A61K47/48 , C07C233/03 , C07D209/32 , A61K39/395
CPC分类号： C07D263/04 , A61K38/00 , A61K47/54 , C07C235/74 , C07K1/1077
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公开(公告)号：EP1171405A1
公开(公告)日：2002-01-16
申请号：EP00920852.1
申请日：2000-04-20
IPC分类号： C07B41/06 , C07B61/00 , C07K1/107 , G01N33/547 , C12Q1/68
CPC分类号： C40B99/00 , C07B41/06 , C07B61/00 , C07D307/24 , C07K1/042 , C40B40/04 , C40B40/10 , C40B50/14 , Y02P20/55
摘要： The invention concerns a functionalised solid support for the synthesis of compounds comprising at least an α-oxoaldehyde function, its method for preparation and its uses, in particular for preparing a bank of organic compounds, a diagnostic reagent, a microtitration plate and a biochip, such as a DNA chip. The invention also concerns a method for the synthesis of organic compounds comprising at least an α-oxoaldehyde function and α-oxoaldehyde peptides obtained by said method.
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公开(公告)号：EP1171405B1
公开(公告)日：2007-01-03
申请号：EP00920852.1
申请日：2000-04-20
IPC分类号： C07B41/06 , C07B61/00 , C07K1/107 , G01N33/547 , C12Q1/68
CPC分类号： C40B99/00 , C07B41/06 , C07B61/00 , C07D307/24 , C07K1/042 , C40B40/04 , C40B40/10 , C40B50/14 , Y02P20/55
摘要： The invention concerns a functionalised solid support for the synthesis of compounds comprising at least an alpha -oxoaldehyde function, its method for preparation and its uses, in particular for preparing a bank of organic compounds, a diagnostic reagent, a microtitration plate and a biochip, such as a DNA chip. The invention also concerns a method for the synthesis of organic compounds comprising at least an alpha -oxoaldehyde function and alpha -oxoaldehyde peptides obtained by said method.
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