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1.发明公开USE OF EPIDERMAL GROWTH FACTOR FOR THE MORPHOFUNCTIONAL RESTORATION OF PERIPHERAL NERVES IN DIABETIC NEUROPATHY 有权VERWENDUNG DES EPIDERMALEN WACHSTUMSFAKTORS ZUR MORPHOFUNKELLELLEN WIEDERHERSTELLUNG VON PERIPHEREN NERVEN BEI DIABETISCHER NEUROPATHIE
公开(公告)号：EP2075004A1
公开(公告)日：2009-07-01
申请号：EP07817382.0
申请日：2007-10-01
发明人： FERNÁNDEZ MONTEQUÍN, José, Ignacio , HERRERA MARTINEZ, Luis, Saturnino , BERLANGA ACOSTA, Jorge, Amador , GARCIA DEL BARCO HERRERA, Diana , CIBRIAN VERA, Danay , GUILLEN NIETO, Gerardo, Enrique , UBIETA GÓMEZ, Raimundo , GONZALEZ BLANCO, Sonia , SÁEZ MARTÍNEZ, Vivian María
CPC分类号： A61K38/1808 , A61K9/16 , C07K14/485 , Y10S930/12
摘要： The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as in ischemic neuritis.
摘要翻译： 本发明涉及人类药物，特别是涉及在药物组合物中使用表皮生长因子（EGF），所述组合物通过渗透在神经干和/或神经节周围进行形态功能恢复 的周围神经在痛苦，敏感运动神经病，以及缺血性神经炎。 它也与含EGF的组合物有关，其中该分子可与麻醉剂或镇痛药一起配制或包封在微球中，以及它们用于在疼痛，敏感运动神经病变以及周围神经中形态功能恢复的用途 缺血性神经炎。
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2.发明授权USE OF EPIDERMAL GROWTH FACTOR FOR THE MORPHOFUNCTIONAL RESTORATION OF PERIPHERAL NERVES IN DIABETIC NEUROPATHY 有权生长因子的糖尿病性神经病的末梢神经的形态功能的表皮修复使用
公开(公告)号：EP2075004B1
公开(公告)日：2012-02-08
申请号：EP07817382.0
申请日：2007-10-01
发明人： FERNÁNDEZ MONTEQUÍN, José, Ignacio , HERRERA MARTINEZ, Luis, Saturnino , BERLANGA ACOSTA, Jorge, Amador , GARCIA DEL BARCO HERRERA, Diana , CIBRIAN VERA, Danay , GUILLEN NIETO, Gerardo, Enrique , UBIETA GÓMEZ, Raimundo , GONZALEZ BLANCO, Sonia , SÁEZ MARTÍNEZ, Vivian María
CPC分类号： A61K38/1808 , A61K9/16 , C07K14/485 , Y10S930/12
摘要： The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anaesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.
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