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1.发明公开USE OF EPIDERMAL GROWTH FACTOR FOR THE MORPHOFUNCTIONAL RESTORATION OF PERIPHERAL NERVES IN DIABETIC NEUROPATHY 有权VERWENDUNG DES EPIDERMALEN WACHSTUMSFAKTORS ZUR MORPHOFUNKELLELLEN WIEDERHERSTELLUNG VON PERIPHEREN NERVEN BEI DIABETISCHER NEUROPATHIE
公开(公告)号：EP2075004A1
公开(公告)日：2009-07-01
申请号：EP07817382.0
申请日：2007-10-01
发明人： FERNÁNDEZ MONTEQUÍN, José, Ignacio , HERRERA MARTINEZ, Luis, Saturnino , BERLANGA ACOSTA, Jorge, Amador , GARCIA DEL BARCO HERRERA, Diana , CIBRIAN VERA, Danay , GUILLEN NIETO, Gerardo, Enrique , UBIETA GÓMEZ, Raimundo , GONZALEZ BLANCO, Sonia , SÁEZ MARTÍNEZ, Vivian María
CPC分类号： A61K38/1808 , A61K9/16 , C07K14/485 , Y10S930/12
摘要： The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as in ischemic neuritis.
摘要翻译： 本发明涉及人类药物，特别是涉及在药物组合物中使用表皮生长因子（EGF），所述组合物通过渗透在神经干和/或神经节周围进行形态功能恢复 的周围神经在痛苦，敏感运动神经病，以及缺血性神经炎。 它也与含EGF的组合物有关，其中该分子可与麻醉剂或镇痛药一起配制或包封在微球中，以及它们用于在疼痛，敏感运动神经病变以及周围神经中形态功能恢复的用途 缺血性神经炎。
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2.发明公开
公开(公告)号：EP2915541A1
公开(公告)日：2015-09-09
申请号：EP13759116.0
申请日：2013-08-02
申请人： Centro De Ingenieria Genetica Y Biotecnologia , Consejo Superior De Investigaciones Científicas (CSIC)
发明人： SANTANA MILIÁN, Héctor,Jesús , VENTOSA RULL, Leonor , MARTÍNEZ DÍAZ, Eduardo , BERLANGA ACOSTA, Jorge, Amador , CABRERA PUIG, Ingrid , VECIANA MIRÓ, Jaume
CPC分类号： A61K38/1808 , A61K8/14 , A61K8/416 , A61K8/63 , A61K8/64 , A61K9/0014 , A61K9/127 , A61K9/1271 , A61K9/1277 , A61K47/186 , A61K47/28 , A61K2800/805 , A61L26/0066 , A61L2300/414 , A61Q19/08
摘要： The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.
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3.发明公开COMPOUNDS ANALOGOUS TO GROWTH HORMONE PEPTIDE SECRETAGOGUES AND PREPARATIONS CONTAINING THEM 有权与生长激素肽类似物相容的化合物以及含有它们的制剂
公开(公告)号：EP1997827A1
公开(公告)日：2008-12-03
申请号：EP07711101.1
申请日：2007-02-28
发明人： RODRIGUEZ FERNANDEZ, Rolando, Eduardo , DE LA NUEZ VEULENS, Ania , ESTRADA GARCÍA, Mario, Pablo , MARTÍNEZ RODRÍGUEZ, Rebeca , CHINEA SANTIAGO, Glay , REYES ACOSTA, Osvaldo , FERNÁNDEZ MASSÓ, Julio, Raúl , GARCÍA DEL BARCO HERRERA, Diana , BERLANGA ACOSTA, Jorge, Amador , MUSACCHIO LASA, Alexis
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过计算机模拟分子模型获得的肽化学化合物，具有使它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养增补剂或其它人或动物用途制剂中的用途。
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4.发明授权VESICLES WHICH INCLUDE EPIDERMAL GROWTH FACTOR AND COMPOSITIONS THAT CONTAIN SAME 有权VESIKEL ENTHALTEND EPIDERMALER WACHSTUMFAKTOR UND DIEE ENTHALTENDE ZUSAMMENSETZUNGEN
公开(公告)号：EP2915541B1
公开(公告)日：2016-11-09
申请号：EP13759116.0
申请日：2013-08-02
申请人： Centro De Ingenieria Genetica Y Biotecnologia , Consejo Superior De Investigaciones Científicas (CSIC)
发明人： SANTANA MILIÁN, Héctor,Jesús , VENTOSA RULL, Leonor , MARTÍNEZ DÍAZ, Eduardo , BERLANGA ACOSTA, Jorge, Amador , CABRERA PUIG, Ingrid , VECIANA MIRÓ, Jaume
CPC分类号： A61K38/1808 , A61K8/14 , A61K8/416 , A61K8/63 , A61K8/64 , A61K9/0014 , A61K9/127 , A61K9/1271 , A61K9/1277 , A61K47/186 , A61K47/28 , A61K2800/805 , A61L26/0066 , A61L2300/414 , A61Q19/08
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5.发明授权COMPOUNDS ANALOGOUS TO GROWTH HORMONE PEPTIDE SECRETAGOGUES AND PREPARATIONS CONTAINING THEM 有权与生长激素肽类似物相容的化合物以及含有它们的制剂
公开(公告)号：EP1997827B1
公开(公告)日：2013-10-09
申请号：EP07711101.1
申请日：2007-02-28
发明人： RODRIGUEZ FERNANDEZ, Rolando, Eduardo , DE LA NUEZ VEULENS, Ania , ESTRADA GARCÍA, Mario, Pablo , MARTÍNEZ RODRÍGUEZ, Rebeca , CHINEA SANTIAGO, Glay , REYES ACOSTA, Osvaldo , FERNÁNDEZ MASSÓ, Julio, Raúl , GARCÍA DEL BARCO HERRERA, Diana , BERLANGA ACOSTA, Jorge, Amador , MUSACCHIO LASA, Alexis
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6.发明公开USE OF A TOPICAL COMPOSITION CONTAINING EPIDERMAL GROWTH FACTOR (EGF) FOR DIABETIC FOOT AMPUTATION PREVENTION 有权USE表皮生长因子（EGF）含局部组合物用于足部合并糖尿病截肢AVOIDANCE
公开(公告)号：EP1970071A1
公开(公告)日：2008-09-17
申请号：EP06828470.2
申请日：2006-12-28
发明人： BETANCOURT RODRIGUEZ, Blas, Yamir , PUPO ESCALONA, Elder , PÁEZ MEIRELES, Rolando , BERLANGA ACOSTA, Jorge, Amador
CPC分类号： A61K9/127 , A61K38/1808
摘要： The present invention is related to the use of topical formulations that contain epidermal growth factor encapsulated in or associated to deformable or conventional liposomes to be applied on the surface of and around chronic ischemic skin lesions. The formulations of the present invention, in contrast with the previous art, are useful because they provide a high bioavailability of EGF in the tissue deep below the lesions and for preventing diabetic foot amputation.
摘要翻译： 本发明是涉及使用局部用制剂和灰确实含有包封在或者关联到可变形的或常规的脂质体的周围和慢性缺血性皮肤损害的表面上应用表皮生长因子。 本发明的公式和灰，在与先前的技术相比，因为它们在组织深病变下面和用于防止糖尿病足截肢提供EGF的高生物利用度是有用的。
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7.发明授权USE OF A TOPICAL COMPOSITION CONTAINING EPIDERMAL GROWTH FACTOR (EGF) FOR DIABETIC FOOT AMPUTATION PREVENTION 有权USE表皮生长因子（EGF）含局部组合物用于足部合并糖尿病截肢AVOIDANCE
公开(公告)号：EP1970071B1
公开(公告)日：2014-12-17
申请号：EP06828470.2
申请日：2006-12-28
发明人： BETANCOURT RODRIGUEZ, Blas, Yamir , PUPO ESCALONA, Elder , PÁEZ MEIRELES, Rolando , BERLANGA ACOSTA, Jorge, Amador
CPC分类号： A61K9/127 , A61K38/1808
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8.发明授权USE OF EPIDERMAL GROWTH FACTOR FOR THE MORPHOFUNCTIONAL RESTORATION OF PERIPHERAL NERVES IN DIABETIC NEUROPATHY 有权生长因子的糖尿病性神经病的末梢神经的形态功能的表皮修复使用
公开(公告)号：EP2075004B1
公开(公告)日：2012-02-08
申请号：EP07817382.0
申请日：2007-10-01
发明人： FERNÁNDEZ MONTEQUÍN, José, Ignacio , HERRERA MARTINEZ, Luis, Saturnino , BERLANGA ACOSTA, Jorge, Amador , GARCIA DEL BARCO HERRERA, Diana , CIBRIAN VERA, Danay , GUILLEN NIETO, Gerardo, Enrique , UBIETA GÓMEZ, Raimundo , GONZALEZ BLANCO, Sonia , SÁEZ MARTÍNEZ, Vivian María
CPC分类号： A61K38/1808 , A61K9/16 , C07K14/485 , Y10S930/12
摘要： The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anaesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.
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