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1.发明授权DENGUE VIRUS CAPSID PROTEIN WHICH INDUCES A PROTECTIVE RESPONSE AND PHARMACEUTICAL COMPOSITION 有权登革病毒衣壳蛋白用于诱导保护性反应和药物组合物
公开(公告)号：EP1944038B1
公开(公告)日：2013-11-27
申请号：EP06791279.0
申请日：2006-09-18
发明人： LAZO VAZQUEZ, Laura , HERMIDA CRUZ, Lisset , LOPEZ ABARRATEGUI, Carlos , SIERRA VAZQUEZ, Beatriz de la Caridad , VAZQUEZ RAMUNDO, Susana , VALDEZ PRADO, Iris , GUILLEN NIETO, Gerardo, Enrique , GUZMAN TIRADO, María, Guadalupe , ZULUETA MORALES, Aída
IPC分类号： A61K39/12 , A61K39/295 , C07K14/18
CPC分类号： A61K39/12 , A61K2039/55505 , A61K2039/55566 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： This invention describe the a pharmaceutical compound having the capsid protein of Dengue virus capable of induce in the receptor a protective immune response before the viral challenge without inducing the Abdependent enhancement phenomenon.
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2.发明公开DENGUE VIRUS CAPSID PROTEIN WHICH INDUCES A PROTECTIVE RESPONSE AND PHARMACEUTICAL COMPOSITION 有权登革病毒 - CAPSID-PROTEIN ZUR INDUKTION EINERSCHÜTZENDENREAKION UND PHARMAZEUCHSCHE ZUSAMMENSETZUNG
公开(公告)号：EP1944038A1
公开(公告)日：2008-07-16
申请号：EP06791279.0
申请日：2006-09-18
发明人： LAZO VAZQUEZ, Laura , HERMIDA CRUZ, Lisset , LOPEZ ABARRATEGUI, Carlos , SIERRA VAZQUEZ, Beatriz de la Caridad , VAZQUEZ RAMUNDO, Susana , VALDEZ PRADO, Iris , GUILLEN NIETO, Gerardo, Enrique , GUZMAN TIRADO, María, Guadalupe , ZULUETA MORALES, Aída
IPC分类号： A61K39/12 , A61K39/295 , C07K14/18
CPC分类号： A61K39/12 , A61K2039/55505 , A61K2039/55566 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： This invention describe the a pharmaceutical compound having the capsid protein of Dengue virus capable of induce in the receptor a protective immune response before the viral challenge without inducing the Abdependent enhancement phenomenon.
摘要翻译： 本发明描述了具有登革热病毒衣壳蛋白的药物化合物，其能够在病毒攻击之前在受体中诱导保护性免疫应答，而不诱导依赖性增强现象。
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3.发明公开CHIMERIC CHAINS THAT CODE FOR PROTEINS THAT INDUCE EFFECTS DIRECTED AGAINST VIRUSES 有权CHIMÄRISCHENUKLEINSÄURENKODIERENDFÜRPROTEINE，DIE EFFEKTE GEGEN VIREN INDUZIEREN
公开(公告)号：EP1418180A2
公开(公告)日：2004-05-12
申请号：EP02760073.3
申请日：2002-07-12
申请人： CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CIGB) , Instituto de Medicina Tropical 'Pedrokouri'
发明人： HERMIDA CRUZ, Lisset , RODRIGUEZ DIAZ, Rayner; , LAZO VAZQUEZ, Laura , ZULUETA MORALES, Aida , LOPEZ ABARRATEGUI, Carlos , VALDES PRADO, Iris , SILVA RODRIGUEZ, Ricardo de la C. , CHINEA SANTIAGO, Glay , GUILLEN NIETO, Gerardo Enrique , GUZMAN TIRADO, Maria Guadalupe , SIERRA VAZQUEZ, Beatriz de la Caridad , ESPINOSA PEREZ, Raul Rafael
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码能够在受体中诱导针对登革热病毒感染的血清型特异性和保护性体液免疫应答的蛋白质的嵌合链，从而消除了血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白的基因的片段的特异性组合组成，并且编码来自登革病毒的包膜（E）蛋白的区域的片段，其在插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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4.发明公开METHODS AND PROTEINS FOR THE PROPHYLACTIC AND/OR THERAPEUTIC TREATMENT OF THE FOUR SEROTYPES OF DENGUE VIRUS AND OTHER FLAVIVIRUSES 审中-公开方法和蛋白质用于预防和/或四种登革热病毒等多种黄病毒血清型的治疗
公开(公告)号：EP1958959A2
公开(公告)日：2008-08-20
申请号：EP06817996.9
申请日：2006-11-21
发明人： CHINEA SANTIAGO, Glay , HUERTA GALINDO, Vivian , MARTÍN DUNN, Alejandro, Miguel , GAVILONDO COWLEY, Jorge, Victor , FLEITAS SALAZAR, Noralvis , GUIROLA CRUZ, Osmany , GIL VALDÉS, Jeovanis , ZULUETA MORALES, Aída , HERMIDA CRUZ, Lisset , AYALA AVILA, Marta , GONZÁLEZ ROCHE, Diamilé , PAEZ MEIRELES, Rolando , TOLEDO MAYORA, Patricia, Gabriela , SARRÍA NÚÑEZ, Mónica , MUSACCHIO LASA, Alexis , MAZOLA REYES, Yuliet
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/55566 , C07K2319/02 , C07K2319/21 , C12N2770/24022 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to the field of the pharmaceutical industry, and describes a conserved area on the surface of the E protein that can be used for the development of wide-spectrum antiviral molecules to be employed in the prophylaxis and/or treatment of infections due to Dengue Virus serotypes 1-4 and other flaviviruses. The invention also covers chimeric proteins to be used as vaccines or as a prophylactic or therapeutic treatment against the four serotypes of Dengue Virus and other flaviviruses.
摘要翻译： 本发明涉及制药工业领域，并且描述了E蛋白的表面上的一个保守的区域也可用于广谱抗病毒分子的发展感染的预防和/或治疗要采用 由于登革热病毒血清型1-4和其他黄病毒。 因此，本发明涵盖了嵌合蛋白用作疫苗或作为针对登革病毒和其他黄病毒的四种血清型的预防或治疗性治疗。
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5.发明授权CHIMERIC CHAINS THAT CODE FOR PROTEINS THAT INDUCE EFFECTS DIRECTED AGAINST VIRUSES 有权嵌合核酸编码蛋白质的影响病毒INDUCE
公开(公告)号：EP1418180B1
公开(公告)日：2006-12-27
申请号：EP02760073.3
申请日：2002-07-12
申请人： CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CIGB) , Instituto de Medicina Tropical 'Pedrokouri'
发明人： HERMIDA CRUZ, Lisset , RODRIGUEZ DIAZ, Rayner; , LAZO VAZQUEZ, Laura , ZULUETA MORALES, Aida , LOPEZ ABARRATEGUI, Carlos , VALDES PRADO, Iris , SILVA RODRIGUEZ, Ricardo de la C. , CHINEA SANTIAGO, Glay , GUILLEN NIETO, Gerardo Enrique , GUZMAN TIRADO, Maria Guadalupe , SIERRA VAZQUEZ, Beatriz de la Caridad , ESPINOSA PEREZ, Raul Rafael
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
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