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1.发明公开Method for obtaining recombinant surface antigen of hepatitis B virus (HEP B) of higher immunogenic capacity and use thereof in a vaccine preparation 失效一种用于生产具有增强的免疫原性的能力和使用的，重组的乙肝表面抗原的疫苗制剂的方法
公开(公告)号：EP0864649A3
公开(公告)日：1998-11-11
申请号：EP98202021.6
申请日：1991-10-07
发明人： Muzio, Gonzalez, Verena L. Muzio , Penton Arias, Eduardo , Fontirrochi Escobar, Giuvel , Nazabal Galvez, Marcelo , Gonzalez Griego, Marta de Jesus , Beldarrain Iznaga, Alejandro , Padron Gonzalez, Guillermo Julio , Albajes, Victoria Ramirez , Garcia Pena, Arnaldo , Ruiz Cruz, Carlos Enrique , Izquierdo Lopez, Gladys Mabel , Herrera Martinez, Luis Saturnino , Duarte Cano, Carlos Antonio , Pérez Suarez, Lilia Luisa , Garcia Suarez, José , de la Riva de la Riva, Gustavo Alberto , Santiago Avila, Ramon Alexis , Ayon Zorrilla, Filiberto Rosendo , Paez Meireles, Rolando , Agraz Fierro, Alberto , Diaz Betancourt, Raul Enrique , Quinones Maya, Yair
CPC分类号： C07K14/005 , A61K39/00 , C07K16/082 , C12N15/815 , C12N2730/10122
摘要： A multi-step process for recovering hepatitis B surface antigen from Pichia pastoris cells containing a gene encoding said hepatitis B surface antigen and having expressed it. The process leads to a high yield of very pure, homogeneous HBsAg in a particulated form having a high immunogenicity, suitable for use in vaccine compositions for treating human beings and for use in diagnostic methods.
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2.发明授权Method for obtaining recombinant surface antigen of hepatitis B virus (HEP B) of higher immunogenic capacity and use thereof in a vaccine preparation 失效一种用于生产具有增强的免疫原性的能力和使用的，重组的乙肝表面抗原的疫苗制剂的方法
公开(公告)号：EP0864649B1
公开(公告)日：2006-04-26
申请号：EP98202021.6
申请日：1991-10-07
发明人： Muzio, González, Verena L. , Penton Arias, Eduardo , Fontirrochi Escobar, Giuvel , Nazábal Gálvez, Marcelo , González Griego, Marta de Jesus , Beldarrain Iznaga, Alejandro , Padron Gonzalez, Guillermo Julio , Ramirez Albajes, Victoria , Garcia Pena, Arnaldo , Ruiz Cruz, Carlos Enrique , Izquierdo Lopez, Gladys Mabel , Herrera Martinez, Luis Saturnino , Duarte Cano, Carlos Antonio , Pérez Suarez, Lilia Luisa , Garcia Suárez, José , de la Riva de la Riva, Gustavo Alberto , Santiago Avila, Ramon Alexis , Ayon Zorrilla, Filiberto Rosendo , Paez Meireles, Rolando , Agraz Fierro, Alberto , Diaz Betancourt, Raul Enrique , Quinones Maya, Yair
CPC分类号： C07K14/005 , A61K39/00 , C07K16/082 , C12N15/815 , C12N2730/10122
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3.发明公开Method for obtaining recombinant surface antigen of hepatitis B virus (HEP B) of higher immunogenic capacity and use thereof in a vaccine preparation 失效一种用于生产具有增强的免疫原性的能力和使用的，重组的乙肝表面抗原的疫苗制剂的方法
公开(公告)号：EP0864649A2
公开(公告)日：1998-09-16
申请号：EP98202021.6
申请日：1991-10-07
发明人： Muzio, Gonzalez, Verena L. Muzio , Penton Arias, Eduardo , Fontirrochi Escobar, Giuvel , Nazabal Galvez, Marcelo , Gonzalez Griego, Marta de Jesus , Beldarrain Iznaga, Alejandro , Padron Gonzalez, Guillermo Julio , Albajes, Victoria Ramirez , Garcia Pena, Arnaldo , Ruiz Cruz, Carlos Enrique , Izquierdo Lopez, Gladys Mabel , Herrera Martinez, Luis Saturnino , Duarte Cano, Carlos Antonio , Pérez Suarez, Lilia Luisa , Garcia Suarez, José , de la Riva de la Riva, Gustavo Alberto , Santiago Avila, Ramon Alexis , Ayon Zorrilla, Filiberto Rosendo , Paez Meireles, Rolando , Agraz Fierro, Alberto , Diaz Betancourt, Raul Enrique , Quinones Maya, Yair
CPC分类号： C07K14/005 , A61K39/00 , C07K16/082 , C12N15/815 , C12N2730/10122
摘要： A multi-step process for recovering hepatitis B surface antigen from Pichia pastoris cells containing a gene encoding said hepatitis B surface antigen and having expressed it. The process leads to a high yield of very pure, homogeneous HBsAg in a particulated form having a high immunogenicity, suitable for use in vaccine compositions for treating human beings and for use in diagnostic methods.
摘要翻译： 用于从含有基因编码巴斯德毕赤酵母细胞中回收B型肝炎表面抗原的多步骤处理所述乙肝表面抗原，并具有过表达它。 该过程导致非常纯的，均匀的HBsAg在微粒形式的高收率的具有高免疫原性，适用于疫苗组合物用于治疗人类和用于诊断方法中使用。
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