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1.发明公开Method for obtaining recombinant surface antigen of hepatitis B virus (HEP B) of higher immunogenic capacity and use thereof in a vaccine preparation 失效用于获得高免疫能力的乙型肝炎病毒（HEP B）的重组表面抗原的方法及其在疫苗制剂中的应用
公开(公告)号：EP0480525A3
公开(公告)日：1992-09-30
申请号：EP91202615.0
申请日：1991-10-07
发明人： Muzio González, Verena Lucila , Penton Arias, Eduardo , Palou, Garcia, Manuel , Fontirrochi Escobar, Giuvel , Nazábal Gálvez, Marcelo , González Griego, Marta de Jesus , Beldarrain Iznaga, Alejandro , Padron González, Guillermo Julio , Ramirez Albajes, Victoria , Garcia Pena, Arnaldo , Ruiz Cruz, Carlos Enrique , Izquierdo Lopez, Gladys Mabel , Herrera Martinez, Luis Saturnino , Duarte Cano, Carlos Antonio , Pérez Suárez, Lilia Luisa , Garcia Suárez, José San Rafael No. 1203 , de la Riva de la Riva, Gustavo Alberto , Santiago Avila, Ramon Alexis , Ayon Zorilla, Filiberto Rosendo , Paez Meireles, Rolando , Agraz Fierro, Alberto , Diaz Betancourt, Raul E. , Quinones Maya, Yair
CPC分类号： C07K14/005 , A61K39/00 , C07K16/082 , C12N15/815 , C12N2730/10122
摘要： A multi-step process for recovering hepatitis B surface antigen from Pichia pastoris cells containing a gene encoding said hepatitis B surface antigen and having expressed it. The process leads to a high yield of very pure, homogeneous HBsAg in a particulated form having a high immunogenicity, suitable for use in vaccine compositions for treating human beings and for use in diagnostic methods.
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2.发明公开Method for obtaining recombinant surface antigen of hepatitis B virus (HEP B) of higher immunogenic capacity and use thereof in a vaccine preparation 失效一种用于生产具有增强的免疫原性的能力和使用的，重组的乙肝表面抗原的疫苗制剂的方法
公开(公告)号：EP0864649A3
公开(公告)日：1998-11-11
申请号：EP98202021.6
申请日：1991-10-07
发明人： Muzio, Gonzalez, Verena L. Muzio , Penton Arias, Eduardo , Fontirrochi Escobar, Giuvel , Nazabal Galvez, Marcelo , Gonzalez Griego, Marta de Jesus , Beldarrain Iznaga, Alejandro , Padron Gonzalez, Guillermo Julio , Albajes, Victoria Ramirez , Garcia Pena, Arnaldo , Ruiz Cruz, Carlos Enrique , Izquierdo Lopez, Gladys Mabel , Herrera Martinez, Luis Saturnino , Duarte Cano, Carlos Antonio , Pérez Suarez, Lilia Luisa , Garcia Suarez, José , de la Riva de la Riva, Gustavo Alberto , Santiago Avila, Ramon Alexis , Ayon Zorrilla, Filiberto Rosendo , Paez Meireles, Rolando , Agraz Fierro, Alberto , Diaz Betancourt, Raul Enrique , Quinones Maya, Yair
CPC分类号： C07K14/005 , A61K39/00 , C07K16/082 , C12N15/815 , C12N2730/10122
摘要： A multi-step process for recovering hepatitis B surface antigen from Pichia pastoris cells containing a gene encoding said hepatitis B surface antigen and having expressed it. The process leads to a high yield of very pure, homogeneous HBsAg in a particulated form having a high immunogenicity, suitable for use in vaccine compositions for treating human beings and for use in diagnostic methods.
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3.发明授权Method for obtaining recombinant surface antigen of hepatitis B virus (HEP B) of higher immunogenic capacity and use thereof in a vaccine preparation 失效一种用于生产具有增强的免疫原性的能力和使用的，重组的乙肝表面抗原的疫苗制剂的方法
公开(公告)号：EP0864649B1
公开(公告)日：2006-04-26
申请号：EP98202021.6
申请日：1991-10-07
发明人： Muzio, González, Verena L. , Penton Arias, Eduardo , Fontirrochi Escobar, Giuvel , Nazábal Gálvez, Marcelo , González Griego, Marta de Jesus , Beldarrain Iznaga, Alejandro , Padron Gonzalez, Guillermo Julio , Ramirez Albajes, Victoria , Garcia Pena, Arnaldo , Ruiz Cruz, Carlos Enrique , Izquierdo Lopez, Gladys Mabel , Herrera Martinez, Luis Saturnino , Duarte Cano, Carlos Antonio , Pérez Suarez, Lilia Luisa , Garcia Suárez, José , de la Riva de la Riva, Gustavo Alberto , Santiago Avila, Ramon Alexis , Ayon Zorrilla, Filiberto Rosendo , Paez Meireles, Rolando , Agraz Fierro, Alberto , Diaz Betancourt, Raul Enrique , Quinones Maya, Yair
CPC分类号： C07K14/005 , A61K39/00 , C07K16/082 , C12N15/815 , C12N2730/10122
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4.发明授权Method for obtaining recombinant surface antigen of hepatitis B virus (HEP B) 失效过程用于获得重组乙肝病毒（HEP B）表面抗原
公开(公告)号：EP0480525B1
公开(公告)日：1999-01-07
申请号：EP91202615.0
申请日：1991-10-07
发明人： Muzio González, Verena Lucila , Penton Arias, Eduardo , Palou, Garcia, Manuel , Fontirrochi Escobar, Giuvel , Nazábal Gálvez, Marcelo , González Griego, Marta de Jesus , Beldarrain Iznaga, Alejandro , Padron González, Guillermo Julio , Ramirez Albajes, Victoria , Garcia Pena, Arnaldo , Ruiz Cruz, Carlos Enrique , Izquierdo Lopez, Gladys Mabel , Herrera Martinez, Luis Saturnino , Duarte Cano, Carlos Antonio , Pérez Suárez, Lilia Luisa , Garcia Suárez, José San Rafael No. 1203 , de la Riva de la Riva, Gustavo Alberto , Santiago Avila, Ramon Alexis , Ayon Zorilla, Filiberto Rosendo , Paez Meireles, Rolando , Agraz Fierro, Alberto , Diaz Betancourt, Raul E. , Quinones Maya, Yair
CPC分类号： C07K14/005 , A61K39/00 , C07K16/082 , C12N15/815 , C12N2730/10122
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5.发明公开Method for obtaining recombinant surface antigen of hepatitis B virus (HEP B) of higher immunogenic capacity and use thereof in a vaccine preparation 失效一种用于生产具有增强的免疫原性的能力和使用的，重组的乙肝表面抗原的疫苗制剂的方法
公开(公告)号：EP0864649A2
公开(公告)日：1998-09-16
申请号：EP98202021.6
申请日：1991-10-07
发明人： Muzio, Gonzalez, Verena L. Muzio , Penton Arias, Eduardo , Fontirrochi Escobar, Giuvel , Nazabal Galvez, Marcelo , Gonzalez Griego, Marta de Jesus , Beldarrain Iznaga, Alejandro , Padron Gonzalez, Guillermo Julio , Albajes, Victoria Ramirez , Garcia Pena, Arnaldo , Ruiz Cruz, Carlos Enrique , Izquierdo Lopez, Gladys Mabel , Herrera Martinez, Luis Saturnino , Duarte Cano, Carlos Antonio , Pérez Suarez, Lilia Luisa , Garcia Suarez, José , de la Riva de la Riva, Gustavo Alberto , Santiago Avila, Ramon Alexis , Ayon Zorrilla, Filiberto Rosendo , Paez Meireles, Rolando , Agraz Fierro, Alberto , Diaz Betancourt, Raul Enrique , Quinones Maya, Yair
CPC分类号： C07K14/005 , A61K39/00 , C07K16/082 , C12N15/815 , C12N2730/10122
摘要： A multi-step process for recovering hepatitis B surface antigen from Pichia pastoris cells containing a gene encoding said hepatitis B surface antigen and having expressed it. The process leads to a high yield of very pure, homogeneous HBsAg in a particulated form having a high immunogenicity, suitable for use in vaccine compositions for treating human beings and for use in diagnostic methods.
摘要翻译： 用于从含有基因编码巴斯德毕赤酵母细胞中回收B型肝炎表面抗原的多步骤处理所述乙肝表面抗原，并具有过表达它。 该过程导致非常纯的，均匀的HBsAg在微粒形式的高收率的具有高免疫原性，适用于疫苗组合物用于治疗人类和用于诊断方法中使用。
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6.发明公开Method for obtaining recombinant surface antigen of hepatitis B virus (HEP B) of higher immunogenic capacity and use thereof in a vaccine preparation 失效过程用于获得具有增强的免疫原性的能力及其在疫苗制剂使用重组乙肝病毒（HEP B）表面抗原。
公开(公告)号：EP0480525A2
公开(公告)日：1992-04-15
申请号：EP91202615.0
申请日：1991-10-07
发明人： Muzio González, Verena Lucila , Penton Arias, Eduardo , Palou, Garcia, Manuel , Fontirrochi Escobar, Giuvel , Nazábal Gálvez, Marcelo , González Griego, Marta de Jesus , Beldarrain Iznaga, Alejandro , Padron González, Guillermo Julio , Ramirez Albajes, Victoria , Garcia Pena, Arnaldo , Ruiz Cruz, Carlos Enrique , Izquierdo Lopez, Gladys Mabel , Herrera Martinez, Luis Saturnino , Duarte Cano, Carlos Antonio , Pérez Suárez, Lilia Luisa , Garcia Suárez, José San Rafael No. 1203 , de la Riva de la Riva, Gustavo Alberto , Santiago Avila, Ramon Alexis , Ayon Zorilla, Filiberto Rosendo , Paez Meireles, Rolando , Agraz Fierro, Alberto , Diaz Betancourt, Raul E. , Quinones Maya, Yair
CPC分类号： C07K14/005 , A61K39/00 , C07K16/082 , C12N15/815 , C12N2730/10122
摘要： A multi-step process for recovering hepatitis B surface antigen from Pichia pastoris cells containing a gene encoding said hepatitis B surface antigen and having expressed it. The process leads to a high yield of very pure, homogeneous HBsAg in a particulated form having a high immunogenicity, suitable for use in vaccine compositions for treating human beings and for use in diagnostic methods.
摘要翻译： 用于从含有基因编码巴斯德毕赤酵母细胞中回收B型肝炎表面抗原的多步骤处理所述乙肝表面抗原，并具有过表达它。 该过程导致非常纯的，均匀的HBsAg在微粒形式的高收率的具有高免疫原性，适用于疫苗组合物用于治疗人类和用于诊断方法中使用。
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