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公开(公告)号：EP1846424B1
公开(公告)日：2010-01-27
申请号：EP06734698.1
申请日：2006-02-10
申请人： CEPHALON, INC.
发明人： OLIVA, Ambrogio , BERNARDNINI, Raffaella , D'ARASMO, Germano , CASSARA, Paolo, G. , BERNAREGGI, Alberto , MENTA, Ernesto
CPC分类号： C07F5/025
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2.发明授权
公开(公告)号：EP1660507B1
公开(公告)日：2009-08-05
申请号：EP04786507.6
申请日：2004-08-13
申请人： CEPHALON, INC.
发明人： BERNAREGGI, ALberto , CASSARA, Paolo, G. , CHATTERJEE, Sankar , FERRETTI, Edmondo , IQBAL, Mohamed , MENTA, Ernesto , MESSINA MCLAUGHLIN, Patricia, A. , OLIVA, Ambrogio , BERNARDINI, Rafaella , DE NUNARI, Sergio , D'ARASMO, Germano
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
摘要翻译： 本发明提供了可通过抑制蛋白酶体活性来调节细胞凋亡的硼酸化合物，硼酸酯及其组合物。 化合物和组合物可用于诱导凋亡和直接与蛋白酶体活性间接相关的疾病如癌症和其它病症的方法中。
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公开(公告)号：EP1846424A1
公开(公告)日：2007-10-24
申请号：EP06734698.1
申请日：2006-02-10
申请人： CEPHALON, INC.
发明人： OLIVA, Ambrogio , BERNARDNINI, Raffaella , D'ARASMO, Germano , CASSARA, Paolo, G. , BERNAREGGI, Alberto , MENTA, Ernesto
CPC分类号： C07F5/025
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.
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公开(公告)号：EP1658255A2
公开(公告)日：2006-05-24
申请号：EP04781132.8
申请日：2004-08-13
申请人： CEPHALON, INC.
IPC分类号： C07C29/00
CPC分类号： C07F5/025
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
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公开(公告)号：EP1660507B9
公开(公告)日：2010-03-24
申请号：EP04786507.6
申请日：2004-08-13
申请人： CEPHALON, INC.
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公开(公告)号：EP1658255B1
公开(公告)日：2009-02-18
申请号：EP04781132.8
申请日：2004-08-13
申请人： CEPHALON, INC.
IPC分类号： C07C29/00
CPC分类号： C07F5/025
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
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公开(公告)号：EP1660507A2
公开(公告)日：2006-05-31
申请号：EP04786507.6
申请日：2004-08-13
申请人： CEPHALON, INC.
发明人： BERNAREGGI, ALberto , CASSARA, Paolo, G. , CHATTERJEE, Sankar , FERRETTI, Edmondo , IQBAL, Mohamed , MENTA, Ernesto , MESSINA MCLAUGHLIN, Patricia, A. , OLIVA, Ambrogio , BERNARDINI, Rafaella
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
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