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1.发明公开Anti-human ovarian cancer immunotoxins and methods of use thereof 失效抗免疫毒素gegen menschlichen Eierstockkrebs和Verfahren zu deren Verwendung。
公开(公告)号：EP0226419A2
公开(公告)日：1987-06-24
申请号：EP86309516.2
申请日：1986-12-05
申请人： CETUS ONCOLOGY CORPORATION , THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE
发明人： Bjorn, Michael Jon , Fitzgerald, David , Frankel, Arthur Edward , Laird, Walter Joseph , Pastan, Ira , Ring, David Barratt , Willingham, Mark , Winkelhake, Jeffrey
IPC分类号： A61K47/00 , A61K39/395 , A61K37/02
CPC分类号： C07K16/30 , A61K38/00 , A61K47/6869 , Y10S424/804 , Y10S424/807 , Y10S514/885 , Y10S530/808 , Y10S530/864
摘要： Immunotoxins comprising a cytotoxic moiety and monoclonal antibodies which bind to human ovarian cancer tissue having at least one of the following capabilities are claimed: cytotoxic ID 50 of 10 nM or less against human ovarian cancer cells, retardation of human ovarian cancer tumor growth in mammals or extension of survival of a mammal carrying a human ovarian cancer tumor. Antigens to which the monoclonal antibody of the immunotoxin bind are identified and characterize the immunotoxins. Methods of killing human ovarian cancer cells, retarding the growth of human ovarian cancer tumors in mammals or extending the survival of mammals carrying human ovarian cancer tumors are claimed.
摘要翻译： 包含细胞毒素部分的免疫毒素和结合至少具有以下能力之一的人卵巢癌组织的单克隆抗体被要求保护：针对人卵巢癌细胞的10nM或更小的细胞毒性ID50，哺乳动物或延伸中人卵巢癌肿瘤生长的延迟 的携带人卵巢癌肿瘤的哺乳动物的存活。 识别免疫毒素结合的单克隆抗体的抗原并表征免疫毒素。 要求杀死人类卵巢癌细胞的方法，阻止哺乳动物中人卵巢癌肿瘤的生长或延长携带人卵巢癌肿瘤的哺乳动物的存活。
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公开(公告)号：EP0226419B1
公开(公告)日：1992-08-05
申请号：EP86309516.2
申请日：1986-12-05
申请人： CETUS ONCOLOGY CORPORATION , THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE
发明人： Bjorn, Michael Jon , Fitzgerald, David , Frankel, Arthur Edward , Laird, Walter Joseph , Pastan, Ira , Ring, David Barratt , Willingham, Mark , Winkelhake, Jeffrey
IPC分类号： A61K47/00 , A61K39/395 , A61K37/02
CPC分类号： C07K16/30 , A61K38/00 , A61K47/6869 , Y10S424/804 , Y10S424/807 , Y10S514/885 , Y10S530/808 , Y10S530/864
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3.发明公开Monoclonal anti-human breast cancer antibodies, corresponding hybridomas, the production and use thereof 失效单克隆抗体对人类乳腺癌，相应的杂交瘤，其制备方法和用途。
公开(公告)号：EP0220858A2
公开(公告)日：1987-05-06
申请号：EP86307735.0
申请日：1986-10-07
IPC分类号： C12P21/00 , C07K15/00 , A61K49/00 , G01N33/574 , G01N33/577 , C12N5/00 , C12N15/00
CPC分类号： A61K49/0058 , A61K51/10 , A61K51/1093 , C07K16/3015 , Y10S424/804 , Y10S424/807 , Y10S435/948 , Y10S530/808 , Y10S530/861
摘要： Hybridomas producing monoclonal antibodies suitable for imaging and diagnosis of human breast tumors and such monoclonal antibodies are claimed. The monoclonals are characterized by breast tumor binding range, breast cancer cell line range, and selectively.
immunoimaging agents comprising the monoclonal antibody and a detectable label, either directly or indirectly conjugated to the antibody are claimed. Methods for imaging breat tumors using the immunoimaging agents are described and claimed.-
4.发明授权Monoclonal anti-human breast cancer antibodies, corresponding hybridomas, the production and use thereof 失效单克隆抗人乳腺癌抗体，相应的杂交瘤，其生产和使用
公开(公告)号：EP0220858B1
公开(公告)日：1993-02-10
申请号：EP86307735.0
申请日：1986-10-07
IPC分类号： C12P21/00 , C07K15/00 , A61K49/00 , G01N33/574 , G01N33/577 , C12N5/00 , C12N15/00
CPC分类号： A61K49/0058 , A61K51/10 , A61K51/1093 , C07K16/3015 , Y10S424/804 , Y10S424/807 , Y10S435/948 , Y10S530/808 , Y10S530/861
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公开(公告)号：EP0226418B1
公开(公告)日：1992-05-27
申请号：EP86309515.4
申请日：1986-12-05
发明人： Bjorn, Michael Jon , Frankel, Arthur Edward , Laird, Walter Joseph , Ring, David Barratt , Winkelhake, Jeffrey Lee
CPC分类号： C07K16/30 , A61K38/00 , A61K47/6869
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公开(公告)号：EP0226418A2
公开(公告)日：1987-06-24
申请号：EP86309515.4
申请日：1986-12-05
发明人： Bjorn, Michael Jon , Frankel, Arthur Edward , Laird, Walter Joseph , Ring, David Barratt , Winkelhake, Jeffrey Lee
CPC分类号： C07K16/30 , A61K38/00 , A61K47/6869
摘要： Immunotoxins comprising a cytotoxic moiety and an antigen binding portion selected from the group consisting of Fab, Fab' and F(ab') 2 fragments of a monoclonal antibody, which binds to human ovarian cancer tissue, having one of the following capabilities are claimed: cytotoxic ID 50 of about 10 nM or less against human ovarian cancer cells, retardation of human ovarian cancer tumor growth in mammals, or extension of survival of a mammal carrying a human ovarian cancer tumor. Antigens or epitopes to which the monoclonal antibodies bind are identified and characterize the immunotoxins. In a preferred embodiment an immunotoxin comprising at least an antigen binding portion of a monoclonal antibody, which binds to human transferrin receptor, but does not block binding of transferrin to the receptor, is described and claimed. Immunotoxin comprising the (F(ab') 2 region of the antitransferrin monoclonal antibody are also claimed.
Methods of killing human ovarian cancer cells, retarding the growth of human ovarian tumors in mammals and extending the survival of mammals carrying human ovarian tumors are claimed.摘要翻译： 免疫毒素，其包括细胞毒性部分和，Fab与抗原选自的Fab“和F（ab”）的单克隆抗体，其结合人卵巢癌组织中的2个片段的选择的结合部分，其具有以下功能之一要求保护： 的抗人卵巢癌细胞，在哺乳动物人卵巢癌肿瘤生长的延迟，或携带一个人卵巢癌肿瘤的哺乳动物的存活延长约10nM或更低的细胞毒性ID50。 抗原或表位的单克隆抗体结合鉴定和表征免疫毒素。 在免疫毒素至少上的单克隆抗体，其结合人运铁蛋白受体，但不阻断运铁蛋白与受体的结合的抗原结合部分，其包含的优选实施例中，描述并要求保护。 疫毒含有（的F（ab“）的抗运铁蛋白的单克隆抗体的2区域是如此要求保护。杀死人卵巢癌细胞，阻滞人类卵巢肿瘤的哺乳动物的生长和延长携带人类卵巢肿瘤的哺乳动物的存活是要求保护的方法。
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