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    Prophylactic agent of hypertension containing a conjugated fatty acid as an effective ingredient and the use thereof
    1.
    发明公开
    Prophylactic agent of hypertension containing a conjugated fatty acid as an effective ingredient and the use thereof 审中-公开
    高血压包含共轭脂肪酸作为活性成分的预防剂，以及它们的使用

    公开(公告)号：EP1493440A1

    公开(公告)日：2005-01-05

    申请号：EP04013770.5

    申请日：2004-06-11

    申请人： RINORU OIL MILLS CO., LTD.

    发明人： Kamegai, Takeshi, c/o Rinoru Oil Mills Co., Ltd. ,  Iwata, Toshio ,  Yamamoto, Takaya, c/o Rinoru Oil Mills Co., Ltd. ,  Yanagita, Teruyoshi ,  Nagao, Koji

    IPC分类号： A61K31/20 ,  A23L1/24 ,  A23L1/30 ,  A61P9/00

    CPC分类号： A61K31/20 ,  A23K20/158 ,  A23L27/60 ,  A23L33/12 ,  A23V2002/00 ,  Y10S424/807 ,  A23V2250/1866

    摘要： The objects of this invention are to prevent or ameliorate hypertension to improve physical constitution and finally to provide feeds, drinks, foods, health food supplements and pharmaceuticals which may be led to the prophylaxis or amelioration of life style related diseases.
    A prophylactic or ameliorating agent of hypertension comprising conjugated fatty acids (e.g., conjugated linoleic acid) as effective ingredients.
    A feed, food and drink, and health food supplement comprising the conjugated fatty acids described above.
    A pharmaceutical comprising the conjugated fatty acids described above.
    A method for prophylactic or ameliorating of hypertension in a mammal, which comprises administering to the mammal an effective amount of a conjugated fatty acid for preventing or ameliorating of hypertension in the mammal.
    Use of a conjugated fatty acid for preparing a pharmaceutical for prophylactic or ameliorating of hypertension.

    摘要翻译： 本发明的目的是预防或改善高血压，改善体质并最终提供饲料，饮料，食品，保健食品补充剂和药物这可能导致预防或生活方式相关的疾病改善。 的高血压的预防或改善剂，其包含共轭脂肪酸（E. G.，共轭亚油酸）作为有效成分。 一种饲料，食品和饮料，保健食品补充剂，其包含上述的共轭脂肪酸。 一种药物包含上述共轭脂肪酸。 一种用于在哺乳动物中，该方法包括给予所述哺乳动物有效量的共轭脂肪酸的用于在哺乳动物中预防或改善高血压的高血压预防或改善方法。 使用的共轭脂肪酸的用于制备药物用于预防或高血压改善性的。

    Monoclonal antibody recognizing alpha 2-- 3 bonds
    2.
    发明公开
    Monoclonal antibody recognizing alpha 2-- 3 bonds 失效
    Alpha 2-3-Verbindungen erkennender monokeparerAntikörper。

    公开(公告)号：EP0316882A2

    公开(公告)日：1989-05-24

    申请号：EP88119045.8

    申请日：1988-11-15

    申请人： MECT CORPORATION

    发明人： Nagai, Yoshitaka ,  Yamamoto, Hideki ,  Takada, Kinji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

    IPC分类号： C12N5/12 ,  C12P21/08

    CPC分类号： G01N33/574 ,  G01N33/5743 ,  G01N33/57469 ,  G01N33/92 ,  Y10S424/807 ,  Y10S530/864

    摘要： A hybridoma capable of procuding a monoclonal antibody specific to a sialic acid containing glycolipid carrying N-­acetylneuraminic acid residue having alpha 2--→ 3 linkage is herein disclosed. The hybridoma can be generated by fusing (i) B cells or lymphocytes obtained by immunizing an animal with a sialic acid containing glycolipid carrying N-­acetylneuraminic acid residue having alpha 2--→ 3 linkage and (ii) myeloma cells. The monoclonal antibody produced by the hybridoma can be used for purifying gangliosides, for treating patients suffering from melanoma and for diagnosing sera.

    摘要翻译： 本文公开了能够诱导具有含唾液酸的糖脂的单克隆抗体的杂交瘤，其携带具有α2 - > 3键的N-乙酰神经氨酸残基。 杂交瘤可以通过融合（i）通过用携带具有α2→3连接的N-乙酰神经氨酸残基和（ii）骨髓瘤细胞的含唾液酸的糖脂免疫动物获得的B细胞或淋巴细胞产生。 由杂交瘤产生的单克隆抗体可用于纯化神经节苷脂，用于治疗患有黑素瘤的患者和用于诊断血清。

    Antibody hybrid molecules and process for their preparation
    10.
    发明公开
    Antibody hybrid molecules and process for their preparation 失效
    混血儿和精神病患者Herstellung。

    公开(公告)号：EP0193161A2

    公开(公告)日：1986-09-03

    申请号：EP86102407.3

    申请日：1986-02-25

    申请人： Xoma Corporation

    发明人： Urnovitz, Howard B.

    IPC分类号： C07K15/00 ,  A61K39/395 ,  A61K47/00 ,  A61K43/00 ,  A61K49/00

    CPC分类号： A61K47/68 ,  Y10S424/804 ,  Y10S424/806 ,  Y10S424/807 ,  Y10S530/861 ,  Y10S530/864

    摘要： Antibodies which contain reduced surfhydryl groups in proximity to the carboxyl terminal end of their heavy chain are coupled to another moiety which has an available sulfhydryl for forming a disulfide bond with the antibodies. IgM is a typical antibody which contains a suitable structure by virtue of its cysteine residue in proximity to the carboxyl terminal end of its heavy chain. A typical hybrid is formed with IgM and the A chain of a toxin such as ricin by the formation of a covalent disulfide bond therebetween. Use of antibodies having structures such as IgM result in hybrid formation in which the moiety joined to the antibody is site directed with respect to its bonding location on the antibody. Such hybrids have utility including in vivo therapeutic applications in which the functionality of the antibody is not deleteriously impaired by the moiety bonded thereto.

    摘要翻译： 在其重链的羧基末端附近含有还原巯基的抗体偶联至另一部分，该部分具有可用的巯基以与抗体形成二硫键。 IgM是典型的抗体，其通过其重链羧基末端附近的半胱氨酸残基含有合适的结构。 通过在其间形成共价二硫键，由IgM和毒素A链形成典型的杂交体，例如蓖麻毒素。 使用具有结构如IgM的抗体导致杂交形成，其中连接到抗体的部分相对于其在抗体上的结合位置是位点指向的。 这样的杂交体具有包括体内治疗应用的效用，其中抗体的功能性不被结合到其上的部分有害地损害。