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公开(公告)号：EP4253388A1
公开(公告)日：2023-10-04
申请号：EP21897229.7
申请日：2021-11-30
发明人： LI, Gang , LU, Lun , HU, Lihong , DING, Charles Z. , CHEN, Shuhui
IPC分类号： C07D519/00 , A61K31/519 , A61P35/00
摘要： Disclosed are a salt form used as a CDC7 inhibitor and a crystal form thereof, and specifically disclosed is a compound represented by formula (II), a crystal form thereof, a preparation method thereof, and an application thereof in the preparation of a drug for preventing or treating tumors.
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公开(公告)号：EP4122931A1
公开(公告)日：2023-01-25
申请号：EP21771264.5
申请日：2021-03-18
发明人： CAI, Zhe , SUN, Fei , DING, Charles Z. , CHEN, Shuhui
IPC分类号： C07D417/04 , A61K31/519 , A61P31/12
摘要： Disclosed are a crystalline form of a Toll-like receptor 8 (TLR8) agonist as represented by formula (I) and a preparation method therefor. Further provided is an application of the crystalline form in the preparation of a drug for treating a disease responsive to the TLR8 agonist.
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公开(公告)号：EP3978501A1
公开(公告)日：2022-04-06
申请号：EP20813107.8
申请日：2020-05-29
发明人： LI, Gang , LU, Lun , ZHANG, Zhibo , HU, Lihong , DING, Charles Z. , CHEN, Shuhui
IPC分类号： C07D495/04 , C07D519/00 , A61K31/519 , A61P35/00
摘要： A new class of tetracyclic compounds acting as Cdc7 inhibitors; specifically disclosed are a compound represented by formula (I), isomers thereof, or pharmaceutically acceptable salts thereof.
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公开(公告)号：EP3854794A1
公开(公告)日：2021-07-28
申请号：EP19862693.9
申请日：2019-09-19
发明人： CAI, Zhe , SUN, Fei , DING, Charles Z. , CHEN, Shuhui
IPC分类号： C07D471/04 , C07D249/08 , A61K31/519 , A61P31/12
摘要： A TLR8 (Toll-like receptor 8) agonist, a compound of the structure shown in formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP3816164A1
公开(公告)日：2021-05-05
申请号：EP19825725.5
申请日：2019-06-25
发明人： ZHANG, Yang , WANG, Jianfei , TAN, Haizhong , LI, Jie , LI, Jian , CHEN, Shuhui
IPC分类号： C07D417/14 , A61K31/519 , A61K31/5377
摘要： Disclosed in the present invention are an IRAK4 inhibitor, and an application thereof in preparation of a drug for treating IRAK4-related diseases. Specifically disclosed are a compound represented by formula (III) and a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP3269715B1
公开(公告)日：2020-05-13
申请号：EP16761108.6
申请日：2016-03-10
发明人： DING, Charles Z. , CHEN, Shuhui , ZHAO, Baoping , XU, Zhaobing , LIU, Yingchun , LIN, Ruibin , WANG, Fei , LI, Jian
IPC分类号： C07D401/14 , C07D403/14 , C07D487/08 , C07D487/10 , C07D498/04 , C07D471/04 , A61P35/00 , A61P35/02
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公开(公告)号：EP3640247A1
公开(公告)日：2020-04-22
申请号：EP18817720.8
申请日：2018-06-14
发明人： LIU, Shilan , LIANG, Guibai , WANG, Hongjian , ZHANG, Ming , CHEN, Shuhui
IPC分类号： C07D401/14 , C07D401/04 , A61K31/498 , A61K31/4709 , A61P35/00 , A61P29/00
摘要： Provided are a Syk inhibitor and a use method therefor, and in particular, disclosed are quinolinone represented by formula (I) or quinazoline derivatives or pharmaceutically acceptable salts thereof, a preparation method, a pharmaceutical composition, and uses in preparing a medicament for treatment of Syk receptor related diseases.
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公开(公告)号：EP3590944A1
公开(公告)日：2020-01-08
申请号：EP18760796.5
申请日：2018-02-28
发明人： XIONG, Jian , XIE, Cheng , CHEN, Kevin X , XU, Xiongbin , ZHANG, Xuejin , GONG, Zhen , LI, Jian , CHEN, Shuhui , ZHANG, Aiming , JIANG, Zhulian , ZHANG, Xiquan , TIAN, Xin
摘要： Disclosed in the present application are a compound represented by formula (I), or a pharmaceutically acceptable salt, a tautomer thereof, a stereoisomer thereof, or a geometrical isomer thereof, and uses thereof in the preparation of drugs for treating or preventing multiple myeloma.
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公开(公告)号：EP3572402A1
公开(公告)日：2019-11-27
申请号：EP18741759.7
申请日：2018-01-23
发明人： MOU, Jianfeng , WU, Songliang , HE, Haiying , GUO, Fengying , WANG, Chuan , LI, Jie , LI, Jian , CHEN, Shuhui
IPC分类号： C07D231/10 , C07D233/54 , C07D261/06 , C07D263/30 , C07D271/06 , C07D271/10 , C07D277/20 , A61K31/33 , A61P1/16
摘要： A compound represented by formula (I), a pharmaceutically acceptable salt or tautomer thereof, and an application of the compound as a caspase inhibitor.
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10.发明公开
公开(公告)号：EP3502103A1
公开(公告)日：2019-06-26
申请号：EP17848166.9
申请日：2017-09-08
发明人： DING, Charles Z. , CHEN, Shuhui , HU, Lihong , XU, Zhaobing , LIU, Yingchun , REN, Bingjie , LI, Weidong , LI, Zongbin , ZHAO, Rui , ZHANG, Xiquan
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
摘要： A crystal form and a salt type of a substituted 2-hydro-pyrazole derivative, preparation method therefor, and use of the crystal form and the salt type in preparation of a medicament for treating cancers such as breast cancer, lung cancer and the like.
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