公开(公告)号：EP2485764A4

公开(公告)日：2014-01-29

申请号：EP10822835

申请日：2010-10-12

申请人： CHILDRENS MEDICAL CENTER ,  PATH VACCINE SOLUTIONS ,  FUNDACAO BUTANTAN

发明人： MALLEY RICHARD ,  ANDERSON PORTER ,  LU YINGJIE ,  ALDERSON MARK ,  ROBERTSON GEORGE A ,  MAISONNEUVE JEAN-FRANCOIS LUCIEN ,  TATE ANDREA MARIA ,  DE OLIVEIRA DIAS WALDELY ,  MIAMONI GONCALVES VIVIANE

IPC分类号： A61K39/395 ,  A61K39/02 ,  A61K39/09 ,  A61P31/00

CPC分类号： A61K39/092 ,  A61K2039/521 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55544

摘要： The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.