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公开(公告)号：EP3384927A1
公开(公告)日：2018-10-10
申请号：EP18153297.9
申请日：2013-11-08
申请人： Merial Inc.
IPC分类号： A61K39/102 , C07K14/285 , C12N1/36
CPC分类号： A61K39/102 , A61K2039/522 , A61K2039/543 , A61K2039/552 , A61K2039/70 , C07K14/285 , C12N1/36
摘要： The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to "shipping fever" or bovine respiratory disease.
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公开(公告)号：EP2931308B1
公开(公告)日：2018-10-10
申请号：EP13811462.4
申请日：2013-12-17
申请人： Eurocine Vaccines AB
IPC分类号： A61K39/145 , A61K39/39 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/543 , A61K2039/55511 , A61K2039/55588 , A61K2039/58 , C12N7/00 , C12N2760/16134 , Y02A50/388 , Y02A50/466
摘要： The invention relates to a composition for use as an intranasally administered vaccine comprising one or more non-live influenza virus antigens, and an adjuvant comprising: one or more carboxylic acids, an aqueous medium, and optionally one or more mono-glycerides.
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公开(公告)号：EP2782458B1
公开(公告)日：2018-09-12
申请号：EP12787031.9
申请日：2012-11-19
申请人： DSM IP Assets B.V. , Novozymes A/S
发明人： WARD , Nelson , KNAP, Inge
IPC分类号： A23K10/18 , A23K20/174 , A23K20/189 , A23K10/14 , A23K20/24 , A23K20/22 , A23K20/26 , A23K20/28 , A23K20/20 , A23K50/70 , A23K50/75 , A61K38/48 , A61K39/012 , A23K20/10 , A61K38/47
CPC分类号： A61K38/48 , A23K10/14 , A23K10/18 , A23K20/10 , A23K20/174 , A23K20/189 , A23K20/22 , A23K20/24 , A23K20/26 , A23K20/28 , A23K20/30 , A23K50/70 , A23K50/75 , A23V2002/00 , A61K38/47 , A61K39/012 , A61K2039/543 , A61K2039/552 , C12Y302/00 , C12Y302/01004 , C12Y302/01008 , C12Y304/00 , C12Y304/21014 , A23V2200/32
摘要： The invention relates to the use of at least one acid stable protease in poultry feed in combination with anti-coccidial vaccination of birds for increasing the performance of vaccinated animals. It has been found surprisingly that the additions of at least one acid stable protease according to the invention to the diet of “cocci”-vaccinated birds have a significant improvement of animal performance. The inventors found that especially the use of serin proteases improve the performance of vaccinated broiler chickens, in particular the use of serin proteases increases weight gain and improves Feed Conversion Ratio (FCR) of cocci-vaccinated birds.
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公开(公告)号：EP2590675B1
公开(公告)日：2018-08-29
申请号：EP11731610.9
申请日：2011-07-07
CPC分类号： C07K17/14 , A61K39/12 , A61K39/155 , A61K47/6929 , A61K2039/543 , A61K2039/55555 , A61K2039/60 , A61K2039/6093 , C12N2760/18534
摘要： Multilayer films comprise polypeptide epitopes from RSV. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films include at least one designed peptide that includes one or more polypeptide epitopes from RSV. Specifically, the multilayer films include two polypeptide epitopes from RSV, such as an epitope that elicits a specific T-cell response such as a cytotoxic T-cell response, and an epitope that elicits a specific antibody response.
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公开(公告)号：EP2214702B1
公开(公告)日：2018-07-04
申请号：EP08846203.1
申请日：2008-10-29
发明人： BECK, Michael , KNITTEL, Jeffrey
IPC分类号： A61K39/02
CPC分类号： C12N1/36 , A61K39/0241 , A61K2039/522 , A61K2039/54 , A61K2039/543 , A61K2039/552 , C12R1/35
摘要： The present invention relates to new attenuated M. bovis bacteria strains. Moreover, the present invention also provides immunogenic compositions comprising live bacteria of an of those attenuated M. bovis bacteria strain, their manufacture and use for the treatment and prophylaxis of M. bovis infections.
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公开(公告)号：EP2081960B1
公开(公告)日：2018-06-27
申请号：EP07821856.7
申请日：2007-10-25
申请人： Ablynx N.V.
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , A61K9/00
CPC分类号： C07K16/3007 , A61K2039/543 , C07K16/28 , C07K2317/569
摘要： The present invention relates to the intranasal delivery of therapeutic polypeptides and proteins comprising a Nanobody®, a domain antibody, a single domain antibody or a “dAb”. The present invention provides compositions comprising a therapeutically effective amount of such polypeptide or protein and further comprising a pharmaceutically acceptable nasal carrier. The invention also relates to methods for the treatment of a subject comprising the delivery of said polypeptides and proteins to said subject by the nasal route.
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公开(公告)号：EP2925354B1
公开(公告)日：2018-06-06
申请号：EP13795795.7
申请日：2013-11-28
IPC分类号： A61K39/102
CPC分类号： A61K39/102 , A61K39/155 , A61K39/265 , A61K2039/522 , A61K2039/5254 , A61K2039/543 , A61K2039/544 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N2710/16734 , C12N2760/18534 , C12N2760/18634
摘要： The present invention pertains to a vaccine comprising live attenuated Pasteurella multocida bacteria for protection of a ruminant against pneumonia caused by Pasteurella multocida by administration of the vaccine to the upper respiratory tract of the ruminant via atomisation of the vaccine. The invention also pertains to a method to use the vaccine to protect a ruminant against pneumonia caused by Pasteurella multocida bacteria.
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8.发明公开
公开(公告)号：EP3204039A4
公开(公告)日：2018-05-30
申请号：EP15849784
申请日：2015-10-09
IPC分类号： A61K39/155 , A61K9/107 , A61K39/10 , A61P31/04 , A61P31/14
CPC分类号： A61K39/35 , A61K9/0043 , A61K9/1075 , A61K9/143 , A61K39/292 , A61K47/22 , A61K47/26 , A61K47/44 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , C12N7/00 , C12N2730/10134
摘要： The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
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9.发明公开LIVE ATTENUATED ORAL VACCINE AGAINST SHIGELLOSIS AND TYPHOID FEVER 审中-公开减毒口服疫苗对SHIGELLOSIS和TYPHOID FEVER
公开(公告)号：EP3319629A1
公开(公告)日：2018-05-16
申请号：EP16821934.3
申请日：2016-07-06
IPC分类号： A61K39/02 , A61K39/112 , A61P31/04
CPC分类号： A61K39/0283 , A61K39/0275 , A61K2039/522 , A61K2039/523 , A61K2039/543 , A61K2039/70 , Y02A50/476 , Y02A50/484
摘要： Disclosed is the attenuated Salmonella typhi vaccine Ty21a utilized as a vector for Shigella and/or enterotoxogenic E. coli genes stably integrated in the Ty21a chromosome. These genes include a heterologous Shigella sonnei O-antigen biosynthetic gene region that comprises the wzz gene and expresses Shigella sonnei form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system.
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公开(公告)号：EP2430047B1
公开(公告)日：2018-03-28
申请号：EP10719210.6
申请日：2010-05-12
发明人： HOROWITZ, Lawrence , BHATT, Ramesh , KASHYAP, Arun
IPC分类号： C07K16/10 , A61K39/395
CPC分类号： C07K16/1018 , A61K9/0043 , A61K9/0053 , A61K39/145 , A61K2039/505 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/543 , A61K2039/55 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N7/00 , C12N2760/16134
摘要： The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, and methods and means for making such antibodies.
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