公开(公告)号：EP1309682A2

公开(公告)日：2003-05-14

申请号：EP01952721.7

申请日：2001-07-13

申请人： CHIRON CORPORATION

发明人： REINHARD, Christoph, J. ,  GARCIA, Pablo, D.

IPC分类号： C12N15/11 ,  C07K14/705 ,  C12N15/12 ,  C12N5/10 ,  C07K16/28

CPC分类号： C12N15/1138 ,  C07K14/47 ,  C07K2319/00

摘要： Inhibitors of TSPAN-7 are provided that reduce the expression or biological activities of TSPAN-7 in a mammalian cell. TSPAN-7 inhibitors include antisense molecules, ribozymes, antibodies and antibody fragments, proteins and polypeptides as well as small molecules. TSPAN-7 inhibitors find use in compositions and methods for decreasing TSPAN-7 gene expression as well as methods for inhibiting proliferation of mammalian cells, including tumor cells, methods for decreasing the side effects of cancer therapy and methods for treating neoplastic diseases. Also provided are nucleic acids encoding a new member of the tetraspan family, TSPAN-7, and polypeptides encoded thereby.

公开(公告)号：EP1177287A2

公开(公告)日：2002-02-06

申请号：EP00923217.4

申请日：2000-04-10

申请人： CHIRON CORPORATION

发明人： GARCIA, Pablo, D.

IPC分类号： C12N15/12 ,  C12N15/19 ,  C07K14/47 ,  C07K14/52 ,  C07K16/18 ,  C07K16/24 ,  C12N15/62

CPC分类号： C07K14/47 ,  C07K2319/00 ,  C07K2319/02

摘要： Fifteen secreted human proteins and full-length cDNA sequences encoding the proteins have been identified. The proteins have various potential uses as therapeutics, such as for stimulating blood cell generation in patients receiving cancer chemotherapy, for treatment of bone marrow transplantation patients, and for healing fractured bones. The proteins and cDNA sequences can also be used, inter alia, for targeting other proteins to the membrane or extracellular milieu.