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公开(公告)号：EP1333036A4
公开(公告)日：2004-09-29
申请号：EP01970285
申请日：2001-09-28
CPC分类号： C07K14/505 , A61K38/1816 , A61K47/60
摘要： A polyethylene glycol-modified erythropoietin (PEG-modified EPO) obtained by chemically modifying the lysine residue at the 52-position of natural erythropoietin (natural EPO) with polyethylene glycol. To enhance the long-lasting drug effect of EPO without damaging the physiological activity of EPO which is a sugar chain-rich glycoprotein, it has been required to develop a PEG-modified EPO having an extremely high long-lasting drug effect by introducing PEG into a controlled binding site at a controlled number of binding molecules. The above-described PEG-modified EPO shows a high long-lasting drug effect, thereby solving these problems.
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公开(公告)号：EP1790640A4
公开(公告)日：2009-07-29
申请号：EP05782020
申请日：2005-09-09
发明人： TACHIBANA KAZUTAKA , SATO HARUHIKO , OHTA MASATERU , NAKAMURA MITSUAKI , SHIRAISHI TAKUYA , YOSHINO HITOSHI , EMURA TAKASHI , HONMA AKIE , ONUMA ETSURO , KAWATA HIROMITSU , TANIGUCHI KENJI
IPC分类号： C07D233/86 , A61K31/4166 , A61K31/428 , A61K31/454 , A61K31/496 , A61P5/24 , A61P5/28 , A61P13/08 , A61P17/00 , A61P17/08 , A61P17/10 , C07D211/58 , C07D233/74
CPC分类号： C07D417/04 , C07D211/58 , C07D233/74 , C07D233/86 , C07D277/82 , C07D401/04
摘要： A compound represented by the formula (I): [Chemical formula 1] (I) [wherein Q is a group represented by the formula; [Chemical formula 2] (X) or (Y) A is hydrogen, halogeno, -ORa, or C1-4 alkyl optionally substituted by one or more halogen atoms; E's each independently is C1-6 alkyl; m is an integer of 0-3; R2 and R3 each independently is C1-6 alkyl; X1 and X2 each independently is O or S; Y is one member selected among arylene, a divalent 5- or 6-membered monocyclic heterocyclic group, and a divalent 8- to 10-membered fused-ring heterocyclic group;and Z is -CON(-Ra)-, -CO-, -COO-, -NRa-C(=NH)NRb-, -NRa-(C=N-CN)NRb-, -N(-Ra)COO-, -C(=NH)-, -SO2-, -SO2N(-Ra)-, -SO2NR1-, -N(-Ra)CO-, -N(-Ra)CON(-Rb)-, -N(COR1)CO-, -N(-Ra)SO2-, -N(SO2R1)SO2-, -N(-Ra)-, or -N(-Ra)SO2N(-Rb)-], or a salt, prodrug, or solvate of the compound. Also provided is a medicinal composition containing the compound or the like.
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公开(公告)号：EP1775289A4
公开(公告)日：2009-09-02
申请号：EP05768418
申请日：2005-08-03
发明人： TACHIBANA KAZUTAKA , SATO HARUHIKO , OHTA MASATERU , NAKAMURA MITSUAKI , SHIRAISHI TAKUYA , IMAOKA IKUHIRO , YOSHINO HITOSHI , NAGAMUTA MASAHIRO , KAWATA HIROMITSU
IPC分类号： C07D233/66 , A61K31/4164 , A61P13/08 , A61P15/00 , A61P17/00 , A61P17/08 , A61P17/14 , A61P35/00 , A61P43/00
CPC分类号： C07D233/86 , C07D233/76
摘要： Compounds represented by the general formula (I); and drugs and medicinal compositions, containing the compounds: (I) wherein n is an integer of 1 to 20; Q is (II) or (III) A is cyano or the like; B is hydrogen, halogeno, or the like; X1 and X2 are each independently selected from between O and S; E is C1-4 alkyl; and R1, R2, R3 and R4 are each independently selected from between hydrogen and C1-6 alkyl.
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公开(公告)号：EP1634874A4
公开(公告)日：2008-04-02
申请号：EP04745805
申请日：2004-06-11
发明人： TACHIBANA KAZUTAKA , SATO HARUHIKO , OHTA MASATERU , NAKAMURA MITSUAKI , SHIRAISHI TAKUYA , IMAOKA IKUHIRO , YOSHINO HITOSHI , NAGAMUTA MASAHIRO , KAWATA HIROMITSU
IPC分类号： C07D233/86 , A61K31/4166 , A61P5/28 , A61P13/08 , A61P17/02 , A61P17/10 , A61P17/14 , A61P35/00 , A61P43/00
CPC分类号： C07D233/86
摘要： A compound represented by the formula (I): (wherein n is an integer selected among 1 to 20; and R1 and R2 may be the same or different and each represents hydrogen or linear or branched, C1-6 alkyl) and a salt, prodrug, and solvate of the compound. Also provided are a medicine and a medicinal composition which each contains the compound.
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