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    ANTIGEN-BINDING MOLECULE INDUCING IMMUNE RESPONSE TO TARGET ANTIGEN
    1.
    发明公开
    ANTIGEN-BINDING MOLECULE INDUCING IMMUNE RESPONSE TO TARGET ANTIGEN 审中-公开
    ANTIGENBINDENDEMOLEKÜLEZUR INDUZIERUNG EINER IMMUNANTWORT AUF EIN ZIELANTIGEN

    公开(公告)号：EP2752200A1

    公开(公告)日：2014-07-09

    申请号：EP12836146.6

    申请日：2012-09-28

    申请人： Chugai Seiyaku Kabushiki Kaisha

    发明人： IGAWA, Tomoyuki ,  MAEDA, Atsuhiko ,  HARAYA, Kenta ,  TACHIBANA, Tatsuhiko

    IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P43/00 ,  C07K16/28 ,  C07K16/46 ,  C12N15/09

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/283 ,  C07K2317/52 ,  C07K2317/92

    摘要： The present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an FcRn-binding domain having FcRn-binding activity in a neutral pH range, immune responses to the antigen are induced. Furthermore, the present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an FcRn-binding domain having FcRn-binding activity in a neutral pH range, immune responses to the antigen are induced, and also the antigen-binding molecule has cytotoxicity or antiproliferative action against cancer cells, foreign biological species, or such that express the antigen to which the antigen-binding molecule binds.

    摘要翻译： 本发明人已经发现，在已经接受了含有抗原结合结构域的抗原结合分子的活生物体中，所述抗原结合结构域与抗原的结合活性根据离子浓度条件而变化，并且含有在中性中具有FcRn结合活性的FcRn结合结构域 pH范围，诱导对抗原的免疫应答。 此外，本发明人已经发现，在已经接收到抗原结合分子的生物体中，所述抗原结合分子含有抗原结合结构域，其与抗原的结合活性根据离子浓度条件而变化，并且含有具有FcRn结合活性的FcRn结合结构域 中性pH范围，诱导对抗原的免疫应答，并且抗原结合分子也对抗癌结合分子所结合的抗原的癌细胞，外来生物物种或其表达抗原的细胞毒性或抗增殖作用。

    ANTIGEN-BINDING MOLECULES FOR PROMOTING ELIMINATION OF ANTIGENS
    6.
    发明公开
    ANTIGEN-BINDING MOLECULES FOR PROMOTING ELIMINATION OF ANTIGENS 审中-公开

    公开(公告)号：EP3680251A1

    公开(公告)日：2020-07-15

    申请号：EP19197872.5

    申请日：2012-09-28

    申请人： Chugai Seiyaku Kabushiki Kaisha

    发明人： IGAWA, Tomoyuki ,  MAEDA, Atsuhiko ,  HARAYA, Kenta ,  IWAYANAGI, Yuki ,  TACHIBANA, Tatsuhiko

    IPC分类号： C07K16/00

    摘要： The present inventors created antigen-binding molecules containing an antigen-binding domain and an Fcy-receptor-binding domain, wherein the molecules have human-FcRn-binding activity in an acidic pH range condition, the antigen-binding domain changes the antigen-binding activity of the antigen-binding molecules depending on the ion-concentration condition, and the Fcy receptor-binding domain has higher binding activity to the Fcy receptor in a neutral pH range condition than an Fc region of a native human IgG in which the sugar chain bound at position 297 (EU numbering) is a fucose-containing sugar chain.