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    Antiviral combination
    1.
    发明公开
    Antiviral combination 失效
    AntiviralesKombinationspräparat。

    公开(公告)号：EP0329609A2

    公开(公告)日：1989-08-23

    申请号：EP89810100.1

    申请日：1989-02-06

    申请人： CIBA-GEIGY AG

    发明人： Gangemi, J. David, Prof. Dr. ,  Hochkeppel, Heinz-Kurt, Dr.

    IPC分类号： A61K37/66 ,  A61K37/02

    CPC分类号： A61K38/212 ,  A61K38/06 ,  A61K38/05 ,  A61K2300/00

    摘要： Described is a synergistic pharmaceutical combination preparation comprising as component A a hybrid α-interferon the structure of which is derived from human interferon-α-D and -α-B gene fragments and as component B a muramylpeptide. Said preparation can be used for treating viral diseases or reducing the formation of metastases of certain tumors.

    摘要翻译： 描述了一种协同药物组合制剂，其包含作为组分A的杂交α-干扰素，其结构衍生自人干扰素-α-D和-β-B基因片段，并且作为组分B是胞壁酰胺肽。 所述制剂可用于治疗病毒性疾病或减少某些肿瘤转移的形成。

    Novel anti-HIV antibodies
    4.
    发明公开
    Novel anti-HIV antibodies 失效
    Antikörpergegen H.I.V.

    公开(公告)号：EP0519866A1

    公开(公告)日：1992-12-23

    申请号：EP92810445.4

    申请日：1992-06-10

    申请人： CIBA-GEIGY AG

    发明人： Mestan, Jürgen, Dr. ,  Lazdins, Janis K., Dr. ,  Woods-Cook, Kathie A. ,  Hardman, Norman, Dr. ,  Hochkeppel, Heinz-Kurt, Dr.

    IPC分类号： C12N15/13 ,  C12P21/08 ,  C12N15/63 ,  C12N5/10 ,  C12N5/20 ,  A61K39/42 ,  G01N33/569 ,  G01N33/577

    CPC分类号： C07K16/1054 ,  A61K38/00 ,  C07K16/462 ,  C07K2317/24 ,  C07K2317/732

    摘要： The invention concerns monoclonal antibodies and antibody derivatives directed against HIV core protein p24 which recognize p24 expressed on the surface of HIV-infected macrophages and/or kill HIV-infected cells. The monoclonal antibodies of the invention may be murine antibodies or chimeric antibodies consisting of human constant regions and murine variable or hypervariable regions. Methods of manufacture of such antibodies, hybridoma or transfectoma cell lines secreting them and methods for production of the hybridoma or transfectoma cell lines are also encompassed by this invention. The invention further concerns recombinant DNA comprising an insert coding for the variable regions of antibodies against HIV core protein p24 having the mentioned properties, methods of manufacture of such recombinant DNAs, and host cells transformed with such recombinant DNAs.
    The antibodies are especially useful for the prevention of the progression of AIDS and for the treatment of AMS, but can also be used for the diagnosis of HIV infection in an immunoassay.

    摘要翻译： 本发明涉及针对HIV核心蛋白p24的单克隆抗体和抗体衍生物，其识别在HIV感染的巨噬细胞的表面上表达的p24和/或杀死HIV感染的细胞。 本发明的单克隆抗体可以是由人恒定区和鼠可变区或高变区组成的鼠抗体或嵌合抗体。 本发明还包括制备这种抗体，分泌它们的杂交瘤或转染细胞系的方法和用于产生杂交瘤或转染细胞系的方法。 本发明还涉及包含编码具有所述性质的HIV核心蛋白p24抗体的可变区的插入片段的重组DNA，以及用这些重组DNA转化的宿主细胞的方法。 该抗体特别可用于预防AIDS的进展和用于治疗AMS，但也可用于免疫测定中HIV感染的诊断。

    Monoclonal antibodies against interferon-induced human protein in pure form, and test kits containing these antibodies
    7.
    发明公开
    Monoclonal antibodies against interferon-induced human protein in pure form, and test kits containing these antibodies 失效
    干扰素诱导人类人类gereignigter中的蛋白质形式，monoklonaleAntikörperdagegen und dieseAntikörperenthaltendeTestsätze。

    公开(公告)号：EP0242329A2

    公开(公告)日：1987-10-21

    申请号：EP87810225.0

    申请日：1987-04-09

    申请人： CIBA-GEIGY AG

    发明人： Horisberger, Michel André, Dr. ,  Hochkeppel, Heinz-Kurt, Dr. ,  Content, Jean, Dr.

    IPC分类号： C12P21/08 ,  C12N5/18 ,  G01N33/577 ,  G01N33/68

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/4718

    摘要： The invention relates to purified proteins induced in human cells by interferon a or β, RNAs, DNAs and hybrid vectors coding for said proteins, hosts transformed with such a hybrid vector, processes for the preparation and purification of these proteins, DNAs, vectors and hosts, monoclonal antibodies specific to these proteins, monoclonal antibody derivatives, hybridoma cell lines secreting these monoclonal antibodies, the use of the monoclonal antibodies and their derivatives in the qualitative and quantitative determination of these proteins, test kits containing the monoclonal antibodies, and pharmaceutical preparations containing said proteins. A protein of the invention shows antiviral properties ascribed to interferons and may be a valuable indicator of the cell response to an interferon therapy.

    摘要翻译： 本发明涉及通过干扰素α或β，RNAs，DNA和编码所述蛋白质的杂交载体在人细胞中诱导的纯化蛋白质，用这种杂交载体转化的宿主，这些蛋白质，DNA，载体和宿主的制备和纯化方法 ，对这些蛋白质特异性的单克隆抗体，单克隆抗体衍生物，分泌这些单克隆抗体的杂交瘤细胞系，在定性和定量测定这些蛋白质中使用单克隆抗体及其衍生物，含有单克隆抗体的检测试剂盒和含有 说蛋白质。 本发明的蛋白质显示归因于干扰素的抗病毒性质，并且可能是对干扰素治疗的细胞应答的有价值的指标。