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1.发明公开DERIVES HALOGENES DE 1-PHENOXY-3-N ALKYLAMINOPROPAN-2-OL UTILISABLES COMME MARQUEURS DES RECEPTEURS $g(b) ADRENERGIQUES MYOCARDIQUES ET COMME ($g(b)-BLOQUANT) 失效1-苯氧基3-N- ALKYLAMINOPROPAN-2-OL卤代衍生物作为标记物β-肾上腺素能受体以及心肌ALSβ阻滞剂
公开(公告)号：EP0767778A1
公开(公告)日：1997-04-16
申请号：EP95924384.0
申请日：1995-06-29
发明人： APPARU, Marcel , DEMENGE, Pierre , FAGRET, Daniel , GHEZZI, Catherine , MAJID, Samia , MATHIEU, Jean-Paul , MAUCLAIRE, Laurent , PASQUALINI, Roberto , VIDAL, Michel
CPC分类号： A61K49/0433 , C07C217/34 , C07C233/25 , C07C233/27
摘要： Practolol halogenated derivatives, useful as myocardial β adrenergic receptor markers, are of formula (I): in which R1 can be various groups, for example, an isopropyl group, R2 is a group of formula CH=CHX, C CX, O-(CH¿2?)pX or OCH2CH=CHX, with X being an optionally radioactive halogen atom, R?7¿ is O or NHCO and n is equal to 0, 1 or 2. When X is 123¿I?, the derivatives of the invention can be used as markers for assaying myocardial β adrenergic receptors.
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2.发明授权DERIVES HALOGENES DE 1-PHENOXY-3-N ALKYLAMINOPROPAN-2-OL UTILISABLES COMME MARQUEURS DES RECEPTEURS beta ADRENERGIQUES MYOCARDIQUES ET COMME (beta-BLOQUANT) 失效1-苯氧基3-N- ALKYLAMINOPROPAN-2-OL卤代衍生物作为标记物β-肾上腺素能受体以及心肌ALSβ阻滞剂
公开(公告)号：EP0767778B1
公开(公告)日：1998-12-16
申请号：EP95924384.1
申请日：1995-06-29
发明人： APPARU, Marcel , DEMENGE, Pierre , FAGRET, Daniel , GHEZZI, Catherine , MAJID, Samia , MATHIEU, Jean-Paul , MAUCLAIRE, Laurent , PASQUALINI, Roberto , VIDAL, Michel
IPC分类号： C07C233/27 , C07C217/34 , A61K31/165 , A61K31/135 , A61K51/04
CPC分类号： A61K49/0433 , C07C217/34 , C07C233/25 , C07C233/27
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