公开(公告)号：EP3099296A4

公开(公告)日：2017-07-19

申请号：EP15743281

申请日：2015-01-30

申请人： COGNITION THERAPEUTICS INC

发明人： RISHTON GILBERT ,  CATALANO SUSAN M ,  LOOK GARY C

IPC分类号： A61K31/404 ,  A61K31/405 ,  A61P25/00 ,  A61P25/28 ,  C07D209/44 ,  C07D491/048

CPC分类号： C07D209/44 ,  C07D209/62 ,  C07D403/06 ,  C07D491/048 ,  C07D491/056

摘要： Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.

摘要翻译： 异吲哚啉σ-2受体拮抗剂化合物，包含此类化合物的药物组合物，以及用于抑制神经元细胞中Abeta相关突触丢失或突触功能障碍，调节神经元细胞中Aβ相关膜运输变化以及治疗与Abeta病理学相关的认知减退的方法 被提供。

公开(公告)号：EP2747768A4

公开(公告)日：2015-10-21

申请号：EP12825341

申请日：2012-08-27

申请人： COGNITION THERAPEUTICS INC

发明人： CATALANO SUSAN M ,  RISHTON GILBERT ,  IZZO NICHOLAS J

IPC分类号： A61K31/135 ,  C07C211/28 ,  C07C211/29 ,  C07C215/54 ,  C07C217/58 ,  C07C217/62

CPC分类号： C07D235/04 ,  A61K31/135 ,  A61K31/351 ,  A61K31/423 ,  A61K31/454 ,  A61K31/47 ,  A61K31/495 ,  A61K31/5377 ,  C07C43/23 ,  C07C211/15 ,  C07C233/91 ,  C07C267/00 ,  C07D211/22 ,  C07D317/46 ,  G01N33/5058 ,  G01N2333/705 ,  G01N2500/10

摘要： This invention relates to the use sigma-2 receptor antagonists, and of pharmaceutical compositions comprising such compounds, in methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology and more broadly treating with such compounds and compositions neurodegenerative diseases and disorders associated with Abeta pathology. This invention also relates to methods for screening compounds for activity in inhibiting cognitive decline on the basis of their ability to bind to a sigma-2 receptor.

公开(公告)号：EP2747759A4

公开(公告)日：2015-05-13

申请号：EP12824979

申请日：2012-08-27

申请人： COGNITION THERAPEUTICS INC

发明人： CATALANO SUSAN M ,  RISHTON GILBERT ,  IZZO NICHOLAS J

IPC分类号： A61K31/135 ,  C07C211/28 ,  C07C211/29 ,  C07C215/54 ,  C07C217/58 ,  C07C217/62

CPC分类号： C07D491/107 ,  C07B2200/07 ,  C07C211/28 ,  C07C211/29 ,  C07C215/54 ,  C07C217/58 ,  C07C217/62 ,  C07C235/60 ,  C07C317/32 ,  C07C2601/10 ,  C07C2602/10 ,  C07D209/44 ,  C07D211/14 ,  C07D211/22 ,  C07D295/08 ,  C07D295/096 ,  C07D319/18 ,  C07D491/10

摘要： This invention relates to novel diarylamino compounds that bind to the sigma-2 receptor, to pharmaceutical compositions comprising such compounds, and to methods for inhibiting or restoring synapse loss in neuronal cells, modulating a membrane trafficking change in neuronal cells, and treating cognitive decline and neurodegenerative diseases and disorders therewith.

摘要翻译： 本发明涉及与σ-2受体结合的新型二芳基氨基化合物，包含这些化合物的药物组合物，以及用于抑制或恢复神经元细胞突触损失，调节神经元细胞膜运输变化和治疗认知衰退的方法，以及 神经变性疾病及其病症。