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公开(公告)号:EP0918867B1
公开(公告)日:2007-01-24
申请号:EP97937017.8
申请日:1997-07-24
发明人: TONKS, Nicholas , FLINT, Andrew, J.
CPC分类号: C12N9/16 , A61K38/00 , C12N2799/026
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公开(公告)号:EP0918867A2
公开(公告)日:1999-06-02
申请号:EP97937017.0
申请日:1997-07-24
发明人: TONKS, Nicholas , FLINT, Andrew, J.
CPC分类号: C12N9/16 , A61K38/00 , C12N2799/026
摘要: Novel protein tyrosine phosphatases in which the invariant aspartate residue is replaced with an alanine residue and which bind to a tyrosine phosphorylated substrate and are catalytically attenuated are described. Also described are methods of identifying tyrosine phosphorylated proteins which complex with the described protein tyrosine phosphatases.
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