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1.发明公开NOVEL GENETIC SEQUENCES ENCODING STEROID AND JUVENILE HORMONE RECEPTOR POLYPEPTIDES AND USES THEREFOR 审中-公开新的基因序列和类固醇激素幼年受体多肽代码，并使用
公开(公告)号：EP1203022A1
公开(公告)日：2002-05-08
申请号：EP00940058.1
申请日：2000-06-30
CPC分类号： C07K14/43563 , C07K14/721
摘要： The present invention provides isolated nucleic acid molecules encoding polypeptides comprising functional steroid hormone and juvenile hormone receptors, in particular isolated nucleic acid molecules which encode polypeptides comprising the Lucilia cuprina, Myzus persicae, and Bemisia tabaci ecdysone receptors and juvenile hormone receptors. The present invention further provides functional recombinant steroid and juvenile hormone receptors and recombinant polypeptide subunits thereof and derivatives and analogues thereof. The present invention further provides screening systems and methods of identifying insecticidally-active agents which are capable of agonising or antagonising insect receptor function, or alternatively or in addition, which modify the affinity of said receptors for their cellular stimuli (e.g. insect steroids or juvenile hormones) or analogues thereof, or alternatively or in addition, which act as insecticides by virtue of their ability to agonise or antagonise the activity of insect hormones.
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2.发明公开NOVEL GENETIC SEQUENCES ENCODING STEROID AND JUVENILE HORMONE RECEPTOR POLYPEPTIDES AND INSECTICIDAL MODALITIES THEREFOR 审中-公开基因序列编码其类固醇和JUVENILHORMONREZEPTOR多肽CODE和它们作为杀虫剂
公开(公告)号：EP1047778A1
公开(公告)日：2000-11-02
申请号：EP99901506.8
申请日：1999-01-15
CPC分类号： C07K14/721 , C07K14/43563 , C12N2799/026 , G01N33/743
摘要： The present invention provides isolated nucleic acid molecules encoding polypeptides comprising functional steroid hormone and juvenile hormone receptors, in particular isolated nucleic acid molecules which encode polypeptides comprising the Lucilia cuprina and Myzus persicae ecdysone receptors and juvenile hormone receptors. The present invention further provides functional recombinant steroid and juvenile hormone receptors and recombinant polypeptide subunits thereof and derivatives and analogues thereof. The present invention further provides screening systems and methods of identifying insecticidally-active agents which are capable of agonising or antagonising insect receptor function, or alternatively or in addition, which modify the affinity of said receptors for their cellular stimuli (e.g. insect steroids or juvenile hormones) or analogues thereof, or alternatively or in addition, which act as insecticides by viture of their ability to agonise or antagonise the activity of insect hormones.
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