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公开(公告)号：EP0793674B1
公开(公告)日：2000-05-24
申请号：EP95940031.8
申请日：1995-11-17
申请人： CORTECH, INC.
发明人： GYORKOS, Albert , SPRUCE, Lyle, W.
CPC分类号： C07D271/10 , A61K38/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06043 , C07K5/06052 , C07K5/06078 , C07K5/06086 , C07K5/06104 , C07K5/06139 , C07K5/06156 , C07K5/06191 , C07K5/0806 , C07K5/12
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公开(公告)号：EP0979242A2
公开(公告)日：2000-02-16
申请号：EP98918677.0
申请日：1998-04-24
申请人： CORTECH, INC.
发明人： SPRUCE, Lyle, W. , GYORKOS, Albert, C. , CHERONIS, John, C. , GOODFELLOW, Val, S. , LEIMER, Axel, H. , YOUNG, John, M. , GERRITY, James, Ivan
IPC分类号： C07K5/06 , C07K5/08 , C07K5/10 , C07D413/12 , C07D413/14 , C07D271/06 , C07D271/10 , C07D417/12 , A61K31/41 , A61K38/05 , A61K38/06 , A61K38/07 , G01N33/52
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06043 , C07K5/06052 , C07K5/0812 , C07K5/0819 , Y02A50/409 , Y02A50/411 , Y02A50/423 , Y02A50/463
摘要： The present invention relates to cysteine protease inhibitors of the general formula (I): wherein Z is a cysteine protease binding moiety; X and Y are S, O or optionally substituted N; and R1 is optionally substituted alkyl or aryl.
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公开(公告)号：EP0954526A2
公开(公告)日：1999-11-10
申请号：EP97952232.0
申请日：1997-12-05
申请人： CORTECH, INC. , Gyorkos, Albert , Spruce, Lyle W.
发明人： GYORKOS, Albert , SPRUCE, Lyle, W.
IPC分类号： A61K38 , A61K31 , A61P43 , C07D271 , C07D413 , C07D417 , C07D487 , C07D491 , C07D495 , C07K5
CPC分类号： C07D271/10 , A61K38/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06043 , C07K5/06052 , C07K5/06078 , C07K5/06086 , C07K5/06104 , C07K5/06139 , C07K5/06156 , C07K5/06191 , C07K5/0806 , C07K5/12
摘要： The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases.
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4.发明公开COMPOUNDS HAVING BRADYKININ ANTAGONISTIC ACTIVITY AND MU-OPIOID AGONISTIC ACTIVITY 失效CONNECTIONS缓激肽拮抗活性和Mu阿片受体激动剂活动
公开(公告)号：EP0832106A2
公开(公告)日：1998-04-01
申请号：EP96918098.0
申请日：1996-06-04
摘要： The present invention relates to pharmaceutically effective heterodimers comprising a bradykinin antagonist component covalently linked to a mu-opioid agonist component.
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公开(公告)号：EP0793674A1
公开(公告)日：1997-09-10
申请号：EP95940031.0
申请日：1995-11-17
申请人： CORTECH, INC.
发明人： GYORKOS, Albert , SPRUCE, Lyle, W.
CPC分类号： C07D271/10 , A61K38/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06043 , C07K5/06052 , C07K5/06078 , C07K5/06086 , C07K5/06104 , C07K5/06139 , C07K5/06156 , C07K5/06191 , C07K5/0806 , C07K5/12
摘要： The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase.
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公开(公告)号：EP0671941A1
公开(公告)日：1995-09-20
申请号：EP93924412.0
申请日：1993-10-29
申请人： CORTECH, INC.
发明人： CHRONIS, John, C. , BLODGETT, James, K. , GOODFELLOW, Val, Smith , MARATHE, Manoj, V. , SPRUCE, Lyle, W. , WHALLEY, Eric, T.
摘要： A bradykinin antagonist of the formula: (BKAn) (X) (Y) where BKAn is a bradykinin antagonist peptide; Y is a pharmacophore; and X is a bridging link chemically joining the BKAn and Y components.
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公开(公告)号：EP1105412A1
公开(公告)日：2001-06-13
申请号：EP98942211.8
申请日：1998-08-17
申请人： CORTECH, INC.
CPC分类号： C07K5/06052 , A61K38/00 , C07K5/06026 , C07K5/06043 , Y02A50/423
摘要： The present invention provides a method of inhibiting the enzymatic activity of a serine protease comprising contacting such protease with an inhibitory amount of a compound of formula (I), wherein Z is a serine protease binding moiety; and R1 is an optionally substituted alkyl, alkenyl, cycloalkyl or aryl group.
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