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公开(公告)号：EP1301137A4
公开(公告)日：2003-08-20
申请号：EP01950943
申请日：2001-07-05
申请人： CRYOGEN INC
发明人： MURRAY DAVID R , LI HONG
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2017/22054 , A61B2018/0022 , A61B2018/0212 , A61B2018/0268
摘要： A method and apparatus for inflating a balloon (14) at a distal portion of an elongated delivery catheter (12) to contact surrounding biological tissue, and expanding a refrigerant adjacent the balloon to cool the biological tissue to render it non-viable. The inflation of the balloon can be accomplished with the expanded refrigerant of with a separate pressurized fluid. The balloon can act as a heat transfer element, or there can be a separate heat transfer element (30) on the catheter adjacent the balloon. The apparatus can be used to perform a dilation procedure, such as angioplasty, in conjunction with cooling of the surrounding tissue.
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公开(公告)号：EP1192396A4
公开(公告)日：2003-05-07
申请号：EP00944827
申请日：2000-06-23
申请人： CRYOGEN INC
发明人： LI HONG
CPC分类号： F25D3/10 , A61B18/02 , A61B2018/0212 , A61B2018/0262
摘要： A method and apparatus for using a secondary refrigerant (14) to precool and liquefy a primary refrigerant (12), then vaporizing and expanding the primary refrigerant to cool a cold tip (20) of a cryosurgical instrument for ablation of biological tissue, such as cardiovascular tissue, in particular endocardiac tissue and tissue inside a cardiac blood vessel. The secondary refrigerant (14) has a critical temperature above the critical temperature of the primary refrigerant (12), and a cooling temperature below the critical temperature of the primary refrigerant, thereby facilitating the use of of the precooling step to provide liquid primary refrigerant in an operating room environment in which the primary refrigerant could not otherwise be provided in the liquid phase.
摘要翻译： 本发明公开了一种使用次级制冷剂（14）预冷和液化主制冷剂（12），然后汽化和膨胀主制冷剂以冷却冷冻外科器械的冷尖端（20）以消融生物组织的方法和设备， 心血管组织，特别是心脏血管内心脏组织和组织。 次级制冷剂（14）具有高于主制冷剂（12）的临界温度的临界温度和低于主制冷剂的临界温度的冷却温度，由此有利于使用预冷步骤来提供液态主制冷剂 其中主要制冷剂不能以液相提供的操作室环境。
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公开(公告)号：EP1307155A4
公开(公告)日：2006-04-12
申请号：EP01961672
申请日：2001-07-18
申请人： CRYOGEN INC
发明人： KUDARAVALLI RAVIKUMAR , LI HONG
CPC分类号： F25D3/10 , A61B18/02 , A61B2017/00199 , A61B2018/0212 , A61B2018/0262 , F25B9/02 , F25B2309/021 , F25B2700/13 , F25D2400/36
摘要： An apparatus and method for automatic operation of a refrigeration system (10) to provide refrigeration power to a catheter for tissue ablation or mapping. The primary refrigeration system (208) can be open loop or closed loop, and a precool loop will typically be closed loop. Equipment and procedures are disclosed for bringing the system to the desired operational state, for controlling the operation by controlling refrigerant flow rate, for performing safety checks, and for achieving safe shutdown.
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公开(公告)号：EP1177268A4
公开(公告)日：2004-12-01
申请号：EP00921459
申请日：2000-03-27
申请人： CRYOGEN INC
发明人： LI HONG , TAUT DANIEL , REU EUGENE , RYBA ERIC
CPC分类号： C09K5/044 , C09K2205/13
摘要： An optimum gas mixture formulated from a group of component fluids, for use in a miniature mixed gas refrigeration system. The gas mixture has appropriate components, in appropriate concentrations, to optimize refrigeration power and heat transfer capacity, and to minimize plugging of the Joule-Thomson expansion element. The gas mixture is pressurized by a compressor to a pressure less than 750 psia, and preferably less than 420 psia, for safety reasons, and supplied to a heat exchanger. The high pressure outlet of the heat exchanger is connected to a Joule-Thomson expansion element where the high pressure gas is expanded isenthalpically to a lower temperature at least as low as 183K. This low temperature gas cools a heat transfer element mounted in the distal end of the probe, to cool an external object. Return gas flows back through the heat exchanger to pre-cool the incoming high pressure gas mixture.
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