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    CRYOGENIC HEAT EXCHANGER
    1.
    发明授权
    CRYOGENIC HEAT EXCHANGER 失效
    低温热交换器

    公开(公告)号：EP1012521B1

    公开(公告)日：2005-05-25

    申请号：EP98934171.4

    申请日：1998-07-16

    申请人： Cryogen, Inc. ,  Secretary of Commerce of the United States

    发明人： DOBAK, John, D. III ,  RADEBAUGH, Ray ,  MARQUARDT, Eric, D.

    IPC分类号： F28D7/02 ,  F28F7/00 ,  A61B18/02 ,  F28D17/00 ,  F28D9/00 ,  F25B9/02 ,  F28F3/08

    CPC分类号： C09K5/045 ,  A61B18/02 ,  A61B2018/0212 ,  A61B2018/0275 ,  A61B2018/0281 ,  C09K2205/12 ,  C09K2205/122 ,  C09K2205/13 ,  C09K2205/132 ,  F25B9/006 ,  F25B9/02 ,  F25B2309/003 ,  F25B2309/021 ,  F25B2309/022 ,  F25B2309/023 ,  F25B2400/12 ,  F28D7/12 ,  F28F13/06 ,  F28F21/082 ,  F28F21/085 ,  F28F2260/02

    摘要： A microminiature laminated heat exchanger for use in a cryogenic probe, and a method of manufacture. The heat exchanger has high and low pressure flow patterns (46, 48) etched into oxygen free copper sheets (42), with the flow patterns being tortuous paths promoting turbulent flow. The sheets (42) containing the flow patterns are bonded into a laminated assembly in the shape of a cylinder (28), with a high pressure inlet and a low pressure outlet in a first end, and a high pressure outlet and a low pressure inlet in a second end. The high pressure flow path lies alongside the low pressure flow path, with flow in the two paths being in opposite directions, to accomplish counterflow heat exchange. Substantial portions of the flow paths are either parallel to, or transverse to, the longitudinal axis of the heat exchanger, with the resuulting heat flow being essentially radial or axial, respectively.

    摘要翻译： 一种用于低温探头的微小型层状热交换器及其制造方法。 热交换器具有蚀刻到无氧铜片（42）中的高压和低压流动模式（46,48），流动模式是曲折的路径，促进湍流。 包含流动图案的片材（42）被粘合成圆柱体（28）形状的层压组件，在第一端具有高压入口和低压出口，并且高压出口和低压入口 在第二个结尾。 高压流动路径位于低压流动路径的旁边，两个路径中的流动方向相反，以实现逆流热交换。 流动路径的大部分或者平行于热交换器的纵向轴线，或者横向于热交换器的纵向轴线，其结果是，热流分别基本上是径向的或者轴向的。

    CRYOSURGICAL PROBE WITH DISPOSABLE SHEATH
    2.
    发明授权
    CRYOSURGICAL PROBE WITH DISPOSABLE SHEATH 失效
    一次性盖冷冻治疗探头

    公开(公告)号：EP0981292B1

    公开(公告)日：2004-07-28

    申请号：EP97954809.6

    申请日：1997-12-19

    申请人： Cryogen, Inc.

    发明人： DOBAK, John, D., III ,  GHAERZADEH, Kambiz ,  YU, Xiaoyu

    IPC分类号： A61B1/00

    CPC分类号： A61B18/02 ,  A61B17/42 ,  A61B18/0206 ,  A61B18/24 ,  A61B2017/00084 ,  A61B2017/0023 ,  A61B2017/00336 ,  A61B2018/00041 ,  A61B2018/00095 ,  A61B2018/00101 ,  A61B2018/00166 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/306 ,  A61B2090/378 ,  A61B2218/002

    摘要： This invention is a disposable, sterilized sheath (20) for use on a closed loop Joule-Thomson cryosurgical probe (10), the combination of the disposable sheath (20), and the probe (10). The sheath (20) is slipped over the probe (10), thereby separating the probe (10) from the environment. The sheath has a grip (22) which fits over the handle (12) of the probe (10), and an extendible shroud (23) that can be longitudinally extended to cover tubing (18) which is attached to the handle (12). The sheath (20) has a hollow multi-lumen catheter (24) shaped and sized to fit snugly over the cannula (14) of the probe (10). The catheter (24) is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations. A thermally conductive cap or tip (26) fits snugly over the cold tip (16) on the probe (12) and it efficiently transfers heat from the target tissue to the cold tip (16), which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter (24) or conductive tip (16), such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing illumination or laser system. Connections between the instrumentation near the distal end of the catheter (24) and the probe (10) are made via a plurality of lumens passing longitudinally through the wall of the catheter (24).

    PRECOOLED CRYOGENIC ABLATION SYSTEM
    3.
    发明公开
    PRECOOLED CRYOGENIC ABLATION SYSTEM 有权
    VORGEKÜHLTESTIEFTEMERATURABTRAGUNGSVERFAHREN

    公开(公告)号：EP1192396A4

    公开(公告)日：2003-05-07

    申请号：EP00944827

    申请日：2000-06-23

    申请人： CRYOGEN INC

    发明人： LI HONG

    IPC分类号： F25B9/02 ,  A61B18/02 ,  F25D3/10 ,  F25B19/02 ,  A61B18/00

    CPC分类号： F25D3/10 ,  A61B18/02 ,  A61B2018/0212 ,  A61B2018/0262

    摘要： A method and apparatus for using a secondary refrigerant (14) to precool and liquefy a primary refrigerant (12), then vaporizing and expanding the primary refrigerant to cool a cold tip (20) of a cryosurgical instrument for ablation of biological tissue, such as cardiovascular tissue, in particular endocardiac tissue and tissue inside a cardiac blood vessel. The secondary refrigerant (14) has a critical temperature above the critical temperature of the primary refrigerant (12), and a cooling temperature below the critical temperature of the primary refrigerant, thereby facilitating the use of of the precooling step to provide liquid primary refrigerant in an operating room environment in which the primary refrigerant could not otherwise be provided in the liquid phase.

    摘要翻译： 本发明公开了一种使用次级制冷剂（14）预冷和液化主制冷剂（12），然后汽化和膨胀主制冷剂以冷却冷冻外科器械的冷尖端（20）以消融生物组织的方法和设备， 心血管组织，特别是心脏血管内心脏组织和组织。 次级制冷剂（14）具有高于主制冷剂（12）的临界温度的临界温度和低于主制冷剂的临界温度的冷却温度，由此有利于使用预冷步骤来提供液态主制冷剂 其中主要制冷剂不能以液相提供的操作室环境。

    EP0950162A4 -
    4.
    发明公开
    EP0950162A4 - 失效
    EP0950162A4 - Google专利

    公开(公告)号：EP0950162A4

    公开(公告)日：1999-11-17

    申请号：EP97936437

    申请日：1997-08-06

    申请人： CRYOGEN INC ,  US COMMERCE

    IPC分类号： F25D3/10 ,  A61B18/02 ,  C09K5/04 ,  F25B7/00 ,  F25B9/00 ,  F25B9/02 ,  F28D7/12 ,  F28F13/06 ,  F28F21/08 ,  F25B19/02

    CPC分类号： F28D7/12 ,  A61B18/02 ,  A61B2018/0212 ,  A61B2018/0275 ,  A61B2018/0281 ,  C09K5/045 ,  C09K2205/12 ,  C09K2205/122 ,  C09K2205/13 ,  C09K2205/132 ,  F25B7/00 ,  F25B9/006 ,  F25B9/02 ,  F25B2309/003 ,  F25B2309/021 ,  F25B2309/022 ,  F25B2309/023 ,  F25B2400/12 ,  F28F13/06 ,  F28F21/08 ,  F28F2260/00

    摘要： A miniatured mixed gas refrigeration system and method of operation are disclosed, having a coaxial catheter (18) with an inner high pressure supply lumen and an outer low pressure return lumen. An optimum gas mixture is formulated from a group of component fluids, according to calculated thermodynamic properties of a group of candidate fluid mixtures. The gas mixture is pressurized by a compressor (12) to a pressure less than 420 psia, for safety reasons. The distal portion (20) of the outer lumen contains a micro-miniature heat exchanger constructed of laminated plates or sheets. The plates or sheets establish high pressure and low pressure passageways, with high surface area, having a tortuous path for the gas flow to maximize heat exchange. The high pressure outlet of the heat exchanger is connected to a Joule-Thomson expansion element where the high pressure gas is expanded isenthalpically to a lower temperature at least as low as 183K. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter, to cool an external object. Return gas flows back through the heat exchanger to pre-cool the incoming high pressure gas mixture.

    摘要翻译： 公开了一种微型混合气体制冷系统和操作方法，其具有带有内部高压供应管腔和外部低压返回管腔的同轴导管（18）。 根据一组候选流体混合物的计算热力学性质，从一组组分流体中配制最佳气体混合物。 出于安全原因，通过压缩机（12）将气体混合物加压至小于420psia的压力。 外腔的远端部分（20）包含由微孔板或薄片构成的微型热交换器。 该板或片建立高压和低压通道，具有高表面积，具有曲折的气流路径以使热交换最大化。 热交换器的高压出口连接到焦耳 - 汤姆逊膨胀元件，高压气体在其中等焓膨胀到至少低至183K的较低温度。 这种低温气体冷却安装在导管外壁上的传热元件，以冷却外部物体。 回流气体通过热交换器回流以预冷输入的高压气体混合物。

    BALLOON CRYOGENIC CATHETER
    8.
    发明公开
    BALLOON CRYOGENIC CATHETER 有权
    球囊低温导管

    公开(公告)号：EP1301137A2

    公开(公告)日：2003-04-16

    申请号：EP01950943.9

    申请日：2001-07-05

    申请人： Cryogen, Inc.

    发明人： MURRAY, David, R. ,  LI, Hong

    IPC分类号： A61B18/18

    CPC分类号： A61B18/02 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0268

    摘要： A method and apparatus for inflating a balloon (14) at a distal portion of an elongated delivery catheter (12) to contact surrounding biological tissue, and expanding a refrigerant adjacent the balloon to cool the biological tissue to render it non-viable. The inflation of the balloon can be accomplished with the expanded refrigerant of with a separate pressurized fluid. The balloon can act as a heat transfer element, or there can be a separate heat transfer element (30) on the catheter adjacent the balloon. The apparatus can be used to perform a dilation procedure, such as angioplasty, in conjunction with cooling of the surrounding tissue.

    摘要翻译： 一种用于在细长输送导管（12）的远端部分处使气囊（14）膨胀以接触周围生物组织并使邻近气囊的制冷剂膨胀以冷却生物组织以使其不可行的方法和设备。 气囊的膨胀可以用膨胀的制冷剂和单独的加压流体来完成。 球囊可以用作传热元件，或者在导管上邻近球囊处可以存在单独的传热元件（30）。 该装置可以用于执行扩张过程，例如血管成形术，结合周围组织的冷却。

    CRYOSURGICAL PROBE WITH DISPOSABLE SHEATH
    10.
    发明公开
    CRYOSURGICAL PROBE WITH DISPOSABLE SHEATH 失效
    一次性使用外科手术探头

    公开(公告)号：EP0981292A1

    公开(公告)日：2000-03-01

    申请号：EP97954809.6

    申请日：1997-12-19

    申请人： Cryogen, Inc.

    发明人： DOBAK, John, D., III ,  GHAERZADEH, Kambiz ,  YU, Xiaoyu

    IPC分类号： A61B1/00

    CPC分类号： A61B18/02 ,  A61B17/42 ,  A61B18/0206 ,  A61B18/24 ,  A61B2017/00084 ,  A61B2017/0023 ,  A61B2017/00336 ,  A61B2018/00041 ,  A61B2018/00095 ,  A61B2018/00101 ,  A61B2018/00166 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/306 ,  A61B2090/378 ,  A61B2218/002

    摘要： This invention is a disposable, sterilized sheath (20) for use on a closed loop Joule-Thomson cryosurgical probe (10), the combination of the disposable sheath (20), and the probe (10). The sheath (20) is slipped over the probe (10), thereby separating the probe (10) from the environment. The sheath has a grip (22) which fits over the handle (12) of the probe (10), and an extendible shroud (23) that can be longitudinally extended to cover tubing (18) which is attached to the handle (12). The sheath (20) has a hollow multi-lumen catheter (24) shaped and sized to fit snugly over the cannula (14) of the probe (10). The catheter (24) is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations. A thermally conductive cap or tip (26) fits snugly over the cold tip (16) on the probe (12) and it efficiently transfers heat from the target tissue to the cold tip (16), which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter (24) or conductive tip (16), such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing illumination or laser system. Connections between the instrumentation near the distal end of the catheter (24) and the probe (10) are made via a plurality of lumens passing longitudinally through the wall of the catheter (24).

    摘要翻译： 本发明是一种用于闭环Joule-Thomson冷冻外科探针（10），一次性护套（20）和探针（10）的组合的一次性消毒护套（20）。 鞘（20）滑过探头（10），从而将探头（10）与环境分开。 护套具有装配在探针（10）的手柄（12）上的手柄（22）和可纵向延伸以覆盖连接到手柄（12）的管（18）的可延伸护罩（23） 。 护套（20）具有中空的多腔导管（24），其形状和尺寸适合紧密地配合在探针（10）的套管（14）上。 导管（24）不导热，防止来自周围环境的热量传递到气体混合物，并且防止组织在不希望的位置处冻结。 导热帽或尖端（26）紧贴地安装在探头（12）上的冷尖端（16）上，并且其有效地将热量从靶组织传递到冷尖端（16），冷尖端又将热量传递到膨胀的气体 混合物。 各种形式的辅助仪器可以安装在导管（24）或导电尖端（16）上，例如温度传感器，加热器，超声换能器或观察照明或激光系统的光学元件。 靠近导管（24）远端的仪器与探针（10）之间的连接是通过纵向穿过导管（24）的壁的多个管腔实现的。