公开(公告)号：EP1741789A1

公开(公告)日：2007-01-10

申请号：EP06013756.9

申请日：1997-03-12

申请人： CYANAMID IBERICA, SA

发明人： Enjuanes Sanchez, Luis ,  Plana Duran, Juan ,  Alonso Villanueva, Sara ,  Ballesteros Jarreno, M. Luisa ,  Castilla Castrillon, Joaquin ,  Gonzales Martinez, José Manuel ,  Izeta Parmesan, Ander ,  Mendez Zuzunegui, Ana ,  Muntion Saenz, Maria ,  Pénzes, Zoltán, Ph.D. ,  Sanchez Morgado, José Manuel ,  Sanchez Sanchez, Carlos Miguel ,  Smerdou Picazo, Cristian ,  Gurpegui, Isobel Sola

IPC分类号： C12N15/86 ,  C12N7/01 ,  A61K39/225 ,  A61K39/215 ,  A61K35/76

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/215 ,  A61K39/225 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/542 ,  A61K2039/552 ,  C07K16/10 ,  C07K2317/76 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20043 ,  C12N2770/20064

摘要： The vectors comprise a recombinant defective viral genome expressing at least one antigen suitable for the induction of systemic and secretory immune responses or an antibody conferring protection against an infectious agent. The defective viral genome comprises the genome of a parental virus having the viral replicase recognition signals located on ends 3' and 5', further comprising internal deletions, and wherein said defective viral genome depends on a helper virus for its replication and encapsidation. These vectors are suitable for the forming of a recombinant system comprising the aforesaid expression vector, and a helper virus. The system is suitable for the manufacture of mono- and polyvalent vaccines against infectious agents of different animal species, especially pigs, dogs and cats, and as expression vehicles for antibodies protective against infectious agents.

摘要翻译： 所述载体包含重组缺陷病毒基因组中表达适合的全身和分泌免疫应答的诱导或抗体在感染剂赋予针对保护的至少一种抗原。 有缺陷的病毒基因组包括具有位于端部3“和5”，还包括内部缺失的病毒复制酶识别信号的亲本病毒的基因组中，和所述worin缺陷病毒基因组依赖于辅助病毒其复制和衣壳化。 这些载体适用于重组系统包括上述的表达载体，和辅助病毒的形成。 该系统适合于针对不同的动物物种的感染性物质，爱特别是猪，狗和猫的单 - 和多价疫苗的制造中，并作为抗体针对传染剂的保护表达载体。